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Showing 1–7 of 7 results
Advanced filters: Author: Niels Vande Casteele Clear advanced filters

  • IL-12 and IL-23 have been implicated in inflammatory bowel disease. In this Review, Vande Casteele and colleagues summarize the mechanistic role of IL-12 and IL-23 in inflammatory bowel disease, and discuss the clinical development of drugs targeting IL-12 and/or IL-23.

    • Bram Verstockt
    • Azucena Salas
    • Stefania Vetrano
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 20, P: 433-446

  • Biosimilar monoclonal antibodies (mAbs) to TNF are being developed that are highly similar, but not identical to the innovator molecules. CT-P13, a biosimilar of infliximab, is the first anti-TNF mAb to get approval in South Korea, Europe and Canada. However, uncertainties remain about indication extrapolation and interchangeability.

    • Niels Vande Casteele
    • William J. Sandborn
    News & Views
    Nature Reviews Gastroenterology & Hepatology
    Volume: 12, P: 373-374

  • A new discovery strategy, ‘reverse metabolomics’, facilitates high-throughput matching of mass spectrometry spectra in public untargeted metabolomics datasets, and a proof-of-concept experiment identified an association between microbial bile amidates and inflammatory bowel disease.

    • Emily C. Gentry
    • Stephanie L. Collins
    • Pieter C. Dorrestein
    ResearchOpen Access
    Nature
    Volume: 626, P: 419-426

  • Intestinal immune cell trafficking is a tightly regulated process involved in health and disease. This Review discusses the sphingosine 1-phosphate modulators as therapeutic agents in targeting leukocyte trafficking and inflammation in inflammatory bowel disease.

    • Bram Verstockt
    • Stefania Vetrano
    • Severine Vermeire
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 19, P: 351-366

  • The biological effects of cytokines in intestinal homeostasis and disease occur as a result of JAK–STAT signalling. This Review describes the current understanding of JAK–STAT signalling in intestinal homeostasis and inflammatory bowel disease as well as the rationale for therapeutically targeting this pathway.

    • Azucena Salas
    • Cristian Hernandez-Rocha
    • Niels Vande Casteele
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 17, P: 323-337