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Showing 1–6 of 6 results
Advanced filters: Author: Nikolaj Frost Clear advanced filters

  • Risk stratification in non-small cell lung cancer (NSCLC) remains challenging. By combining multiplex immunofluorescence, H&E histology, and AI, the study identifies spatial “cell-niche” patterns that enhance survival prediction beyond UICC8 staging. These patterns reclassify many stage I patients as high risk, revealing potentially undertreated cases and establishing spatial tumor microenvironment features as clinically actionable biomarkers.

    • Simon Schallenberg
    • Gabriel Dernbach
    • Frederick Klauschen
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-25

  • Immune-checkpoint inhibitors have dramatically improved the outcomes in patients with advanced-stage driver-negative non-small-cell lung cancer (NSCLC), although most patients will ultimately have disease progression on these agents and the most effective treatment approach in this scenario remains uncertain. In this Review, the authors describe the outcomes in patients receiving second-line therapy for advanced-stage NSCLC and provide an overview of emerging therapies and future areas of research in this challenging clinical setting.

    • Martin Reck
    • Nikolaj Frost
    • Fabrice Barlesi
    Reviews
    Nature Reviews Clinical Oncology
    Volume: 22, P: 806-830

  • Vultures are scavengers with a high tolerance to bacterial toxins in decaying meat. Here, Roggenbuck et al.show that the vulture’s gut microbiome displays unique features and is dominated by Clostridia and Fusobacteria, two bacterial groups commonly associated with infectious disease in other animals.

    • Michael Roggenbuck
    • Ida Bærholm Schnell
    • Lars H Hansen
    Research
    Nature Communications
    Volume: 5, P: 1-8