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Transport and InsP₈ gating mechanisms of the human inorganic phosphate exporter XPR1

The phosphate exporter XPR1 is essential for maintenance of cellular phosphate levels. Here authors present cryo-EM structures of XPR1 that reveal how binding of the signaling molecule 1,5-InsP₈ to its regulatory domain initiates phosphate release.

Qinyu Zhu
Madeleine F. Yaggi
Melinda M. Diver
ResearchOpen Access20 Mar 2025
Nature Communications

Volume: 16, P: 1-14
A structural exposé of noncanonical molecular reactivity within the protein tyrosine phosphatase WPD loop

Inositol pyrophosphates (PP-IPs) regulate immunity and phosphate homeostasis. Here, the authors’ structural dissection of an Arabidopsis thaliana PP-IP phosphatase reveals that substrates drive their own hydrolysis and identifies a highly elusive metaphosphate-like reaction intermediate.

Huanchen Wang
Lalith Perera
Stephen B. Shears
ResearchOpen Access25 Apr 2022
Nature Communications

Volume: 13, P: 1-13
Analysis of inositol phosphate metabolism by capillary electrophoresis electrospray ionization mass spectrometry

Myo-Inositol phosphates (InsPs) and pyrophosphates (PP-InsPs) are important second messengers but their analysis remains challenging. Here, the authors develop a capillary electrophoresis-mass spectrometry method for the identification and quantitation of InsP and PP-InsP isomers in cells and tissues.

Danye Qiu
Miranda S. Wilson
Henning J. Jessen
ResearchOpen Access27 Nov 2020
Nature Communications

Volume: 11, P: 1-12

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Transport and InsP8 gating mechanisms of the human inorganic phosphate exporter XPR1

A structural exposé of noncanonical molecular reactivity within the protein tyrosine phosphatase WPD loop

Analysis of inositol phosphate metabolism by capillary electrophoresis electrospray ionization mass spectrometry

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Transport and InsP₈ gating mechanisms of the human inorganic phosphate exporter XPR1