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Showing 1–2 of 2 results
Advanced filters: Author: Nirajan Shrestha Clear advanced filters

  • The authors present a genetically encoded tool based on a bifunctional enzyme that can regenerate NAD+ while executing an engineered glycerol shunt. The tool successfully restored redox imbalance and modulated lipid metabolism in vitro and in a mouse hepatic steatosis model.

    • Xingxiu Pan
    • Subrata Munan
    • Valentin Cracan
    Research
    Nature Metabolism
    Volume: 8, P: 350-370

  • A soluble bacterial transhydrogenase from Escherichia coli (EcSTH) was validated as a genetically encoded tool to induce NADH reductive stress in mammalian cells revealing unique transcriptional and metabolic signatures.

    • Xingxiu Pan
    • Mina L. Heacock
    • Valentin Cracan
    Research
    Nature Chemical Biology
    Volume: 20, P: 594-604