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Scientific Reports (23)
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Showing 1–50 of 52 results

Advanced filters: Author: Noriyuki Shimizu Clear advanced filters

Fibroblast-specific PRMT5 deficiency suppresses cardiac fibrosis and left ventricular dysfunction in male mice

Epigenetic mechanisms play a key role in cardiac fibrosis associated with heart failure. Here, the authors show that protein arginine methyltransferase 5 (PRMT5), an epigenetic writer, regulates fibrotic gene transcription through histone methylation in mice.

Yasufumi Katanasaka
Harumi Yabe
Tatsuya Morimoto
ResearchOpen Access19 Mar 2024
Nature Communications

Volume: 15, P: 1-13
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
Synthesis of Wholly Aromatic Polyketones Containing Optically Active Macrocycles

Katsuya Maeyama
Shugo Maeda
Noriyuki Yonezawa
Research26 Feb 2007
Polymer Journal

Volume: 39, P: 342-346
Myonectin protects against skeletal muscle dysfunction in male mice through activation of AMPK/PGC1α pathway

Here the authors show that myonectin functions as a protective factor against age-associated, disuse-induced or steroid-induced muscle atrophy, suggesting that myonectin represents a therapeutic target for preventing skeletal muscle dysfunction.

Yuta Ozaki
Koji Ohashi
Noriyuki Ouchi
ResearchOpen Access04 Aug 2023
Nature Communications

Volume: 14, P: 1-17
Physiological and morphological differences of airways between COPD and asthma–COPD overlap

Masato Karayama
Naoki Inui
Takafumi Suda
ResearchOpen Access24 May 2019
Scientific Reports

Volume: 9, P: 1-8
Whole exome sequencing reveals recurrent mutations in BRCA2 and FAT genes in acinar cell carcinomas of the pancreas

Toru Furukawa
Hitomi Sakamoto
Keiko Shiratori
ResearchOpen Access06 Mar 2015
Scientific Reports

Volume: 5, P: 1-6
In-situ observation of ultrafast 90° domain switching under application of an electric field in (100)/(001)-oriented tetragonal epitaxial Pb(Zr_0.4Ti_0.6)O₃ thin films

Yoshitaka Ehara
Shintaro Yasui
Hiroshi Funakubo
ResearchOpen Access29 Aug 2017
Scientific Reports

Volume: 7, P: 1-7
PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria

The kinase PINK1 is mutated in Parkinson's disease and accumulates in defective mitochondria, where it recruits Parkin. Here, PINK1 is shown to be autophosphorylated and this is required for the localization of PINK1 to mitochondria with a reduced membrane potential, and for the recruitment of Parkin.

Kei Okatsu
Toshihiko Oka
Noriyuki Matsuda
ResearchOpen Access21 Aug 2012
Nature Communications

Volume: 3, P: 1-10
Risk stratification of acute exacerbations by autoantibodies in patients with idiopathic interstitial pneumonia

Shusuke Yazawa
Noriyuki Enomoto
Takafumi Suda
ResearchOpen Access13 Oct 2025
Scientific Reports

Volume: 15, P: 1-11
Rotigotine suppresses sleep-related muscle activity augmented by injection of dialysis patients’ sera in a mouse model of restless legs syndrome

Kazuhiro Muramatsu
Sachiko Chikahisa
Yuichi Inoue
ResearchOpen Access08 Nov 2019
Scientific Reports

Volume: 9, P: 1-9
α6β1 integrin induces proteasome-mediated cleavage of erbB2 in breast cancer cells

Hajime Shimizu
Takashi Seiki
Noriyuki Koyama
Research13 Feb 2003
Oncogene

Volume: 22, P: 831-839
Whole-exome sequencing uncovers frequent GNAS mutations in intraductal papillary mucinous neoplasms of the pancreas

Toru Furukawa
Yuko Kuboki
Keiko Shiratori
ResearchOpen Access18 Nov 2011
Scientific Reports

Volume: 1, P: 1-7
Mast cell involvement in glucose tolerance impairment caused by chronic mild stress with sleep disturbance

Sachiko Chikahisa
Saki Harada
Hiroyoshi Séi
ResearchOpen Access20 Oct 2017
Scientific Reports

Volume: 7, P: 1-11
Genome-Wide Analyses on Loss of Heterozygosity in Head and Neck Squamous Cell Carcinomas

Levent Bekir Beder
Mehmet Gunduz
Kenji Shimizu
Research01 Jan 2003
Laboratory Investigation

Volume: 83, P: 99-105
Injured tubule derived CCN1 exacerbates renal congestion-mediated acute kidney injury and fibrosis

Atsushi Minamida
Tomohiro Nakata
Tetsuro Kusaba
ResearchOpen Access01 Jul 2025
Scientific Reports

Volume: 15, P: 1-18
Toll like receptor 2 mediated exacerbation of sepsis associated acute kidney injury by renal congestion in mice

Itaru Nakamura
Minato Umehara
Tetsuro Kusaba
ResearchOpen Access01 Jul 2025
Scientific Reports

Volume: 15, P: 1-15
Analysis of the relationship between bronchoalveolar lavage lymphocyte fraction and detailed autoimmune features in patients with idiopathic interstitial pneumonia

Noriyuki Enomoto
Masayuki Watanuki
Takafumi Suda
ResearchOpen Access19 Jul 2025
Scientific Reports

Volume: 15, P: 1-9
Effect of Renin-Angiotensin-Aldosterone System Triple Blockade on Non-Diabetic Renal Disease: Addition of an Aldosterone Blocker, Spironolactone, to Combination Treatment with an Angiotensin-Converting Enzyme Inhibitor and Angiotensin II Receptor Blocker

Yoshiyuki Furumatsu
Yasuyuki Nagasawa
Tatsuya Shoji
Research01 Jan 2008
Hypertension Research

Volume: 31, P: 59-67
Vascular smooth muscle RhoA counteracts abdominal aortic aneurysm formation by modulating MAP4K4 activity

RhoA is required in vascular smooth muscle cells to inhibit MAP4K4 and prevent abdominal aortic aneurysm formation.

Md Rasel Molla
Akio Shimizu
Hisakazu Ogita
ResearchOpen Access07 Oct 2022
Communications Biology

Volume: 5, P: 1-17
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

Hiroki Masuda
Masahiro Mori
Satoshi Kuwabara
ResearchOpen Access03 Aug 2023
Scientific Reports

Volume: 13, P: 1-14
A genome-wide association study identifies three new risk loci for Kawasaki disease

Yoshihiro Onouchi and colleagues report the results of a genome-wide association study of Kawasaki disease. They identify three new risk loci, all mapping near genes previously implicated in adult-onset autoimmune diseases.

Yoshihiro Onouchi
Kouichi Ozaki
Adriana H Tremoulet
Research25 Mar 2012
Nature Genetics

Volume: 44, P: 517-521
SAMD9 mutations cause a novel multisystem disorder, MIRAGE syndrome, and are associated with loss of chromosome 7

Satoshi Narumi, Tomonobu Hasegawa and colleagues describe a new adrenal hypoplasia syndrome termed MIRAGE that is caused by mutations in the endosome fusion facilitator SAMD9. They find that patients with these mutations have severe growth restriction phenotypes, and they observe adaptation by aneuploidy, where there is accompanying protective loss of mutation-carrying chromosome 7.

Satoshi Narumi
Naoko Amano
Tomonobu Hasegawa
Research16 May 2016
Nature Genetics

Volume: 48, P: 792-797
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Youngjune Bhak
Vasilis Raptis
Albert Tenesa
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
Streptozotocin induces renal proximal tubular injury through p53 signaling activation

Kunihiro Nakai
Minato Umehara
Tetsuro Kusaba
ResearchOpen Access29 May 2023
Scientific Reports

Volume: 13, P: 1-14
Effects of thienopyridine class antiplatelets on bleeding outcomes following robot-assisted radical prostatectomy

Masashi Kubota
Mutsushi Kawakita
Takayuki Goto
ResearchOpen Access11 Mar 2024
Scientific Reports

Volume: 14, P: 1-10
Association between infertility treatment and hypertensive disorders of pregnancy in the Japan Birth Cohort Consortium: a meta-analysis

Mami Ishikuro
Tomoko Nishimura
Shinichi Kuriyama
Research10 Jan 2024
Journal of Human Hypertension

Volume: 38, P: 187-190
Cumulative DNA damage by repeated low-dose cisplatin injection promotes the transition of acute to chronic kidney injury in mice

Noriyuki Yamashita
Kunihiro Nakai
Tetsuro Kusaba
ResearchOpen Access22 Oct 2021
Scientific Reports

Volume: 11, P: 1-13
Blood pressure during long-term cilostazol-based dual antiplatelet therapy after stroke: a post hoc analysis of the CSPS.com trial

Kazunori Toyoda
Masatoshi Koga
Hiroaki Tanaka
ResearchOpen Access09 Jul 2024
Hypertension Research

Volume: 47, P: 2238-2249
Conditional Deletion of Smad1 Ameliorates Glomerular Injury in Progressive Glomerulonephritis

Makoto Araki
Takeshi Matsubara
Toshio Doi
ResearchOpen Access05 Aug 2016
Scientific Reports

Volume: 6, P: 1-12
Structure and mechanical properties of biobased polyamide 11 specimens subjected to different heat treatments

The relationships between the macroscopic mechanical properties and lamellar structures of polyamide 11 obtained from different heat treatments were investigated. From the tensile tests, the maximum stress and strain at necking increase with the heat treatment temperature. WAXS measurements indicated that different crystalline phases formed depending on the heat treatment conditions. SAXS revealed that the lamellar thickness and long period increased with the heat treatment temperature. Based on these results, we elucidated that the macroscopic mechanical properties correlate with the lamellar thickness and long period.

Toyoshi Yoshida
Mei Touji
Yoshihisa Kaneko
Research03 Jun 2024
Polymer Journal

Volume: 56, P: 833-845
Allelic loss and reduced expression of the ING3, a candidate tumor suppressor gene at 7q31, in human head and neck cancers

Mehmet Gunduz
Mamoru Ouchida
Kenji Shimizu
Research25 Jun 2002
Oncogene

Volume: 21, P: 4462-4470
Coalescence of non-equilibrium spheres through thermal annealing in a polystyrene-block-poly(ethylene-co-butylene)-block-polystyrene triblock copolymer film under a uniaxially stretched state

We report experimental results of an attempt to control the orientation of cylindrical microdomains using the directional coalescence of non-equilibrium spheres along the stretching direction of a triblock copolymer film specimen. Thermal annealing, which induced the sphere-to-cylinder transition, was performed on the triblock copolymer film under a uniaxially stretched state. Unlike the application of shear flow, cylinder orientation with its long axis parallel to the stretching direction was not achieved by uniaxial stretching.

Shogo Tomita
Nobutaka Shimizu
Shinichi Sakurai
Research08 Mar 2017
Polymer Journal

Volume: 49, P: 519-526
Three novel mutations of the PAX6 gene in Japanese aniridia patients

Toshio Kawano
Chunxia Wang
Shinsei Minoshima
Research14 Jun 2007
Journal of Human Genetics

Volume: 52, P: 571-574
Clinicopathological significance of somatic RNF43 mutation and aberrant expression of ring finger protein 43 in intraductal papillary mucinous neoplasms of the pancreas

Hitomi Sakamoto
Yuko Kuboki
Toru Furukawa
Research01 Aug 2014
Modern Pathology

Volume: 28, P: 261-267
GDE5/Gpcpd1 activity determines phosphatidylcholine composition in skeletal muscle and regulates contractile force in mice

Skeletal muscle-specific GDE5/Gpcpd1 deletion leads to glycerophosphocholine accumulation, which alters skeletal muscle phospholipid profiles and reduces passive force in electrically stimulated skeletal muscles in vivo.

Rahmawati Aisyah
Noriyasu Ohshima
Noriyuki Yanaka
ResearchOpen Access20 May 2024
Communications Biology

Volume: 7, P: 1-17
Influence of hospital capabilities and prehospital time on outcomes of thrombectomy for stroke in Japan from 2013 to 2016

Ai Kurogi
Daisuke Onozuka
Masayuki Yokota
ResearchOpen Access28 Feb 2022
Scientific Reports

Volume: 12, P: 1-17
Polo-like kinases (Plks) and cancer

Noriyuki Takai
Ryoji Hamanaka
Isao Miyakawa
Reviews10 Jan 2005
Oncogene

Volume: 24, P: 287-291
Pain sensitivity increases with sleep disturbance under predictable chronic mild stress in mice

Junhel Dalanon
Sachiko Chikahisa
Yoshizo Matsuka
ResearchOpen Access09 Jul 2021
Scientific Reports

Volume: 11, P: 1-10
Vascular RAGE transports oxytocin into the brain to elicit its maternal bonding behaviour in mice

Yasuhiko Yamamoto et al. show that oxytocin is transported into the brain by the receptor for advanced glycation end-products (RAGE) on the blood-brain barrier. This study explains how circulating oxytocin crosses the blood-brain barrier, which is important to manifest oxytocin’s maternal bonding effects.

Yasuhiko Yamamoto
Mingkun Liang
Haruhiro Higashida
ResearchOpen Access25 Feb 2019
Communications Biology

Volume: 2, P: 1-13
Functional shell matrix proteins tentatively identified by asymmetric snail shell morphology

Akito Ishikawa
Keisuke Shimizu
Kazuyoshi Endo
ResearchOpen Access17 Jun 2020
Scientific Reports

Volume: 10, P: 1-12
Ultrathin silicon oxynitride layer on GaN for dangling-bond-free GaN/insulator interface

Kengo Nishio
Tomoe Yayama
Mitsuaki Shimizu
ResearchOpen Access23 Jan 2018
Scientific Reports

Volume: 8, P: 1-10
Expression of Smad1 is directly associated with mesangial matrix expansion in rat diabetic nephropathy

Takeshi Matsubara
Hideharu Abe
Toshio Doi
Research13 Feb 2006
Laboratory Investigation

Volume: 86, P: 357-368
Angiotensin II-dependent Src and Smad1 signaling pathway is crucial for the development of diabetic nephropathy

Akira Mima
Takeshi Matsubara
Toshio Doi
Research12 Jun 2006
Laboratory Investigation

Volume: 86, P: 927-939
Combined assessment of the GAP index and body mass index at antifibrotic therapy initiation for prognosis of idiopathic pulmonary fibrosis

Yuzo Suzuki
Kazutaka Mori
Takafumi Suda
ResearchOpen Access17 Sept 2021
Scientific Reports

Volume: 11, P: 1-9
Anti-PDHA1 antibody is detected in a subset of patients with schizophrenia

Yukako Nakagami
Genichi Sugihara
Kosaku Murakami
ResearchOpen Access13 May 2020
Scientific Reports

Volume: 10, P: 1-12
Exclusive formation of stereocomplex crystallites in PLLA/PDLA (50/50) blends by the addition of a plasticizer

The effects of an organic monoglyceride (OMG) plasticizer on the crystallization of the PLLA/PDLA (50/50) blend were investigated by examining the isothermal crystallization of the blend with different contents of OMG (1–5 wt%) using POM, DSC, and time-resolved WAXD. It was found that the increase of the OMG content promoted the exclusive formation of stereocomplex crystallites and enhanced its crystallinity while suppressing the formation of homocrystals.

Neimatallah Hosni Mohammed Mahmoud
Hideaki Takagi
Shinichi Sakurai
Research24 May 2024
Polymer Journal

Volume: 56, P: 819-831
Revisit of crystal orientation in a vulcanizate of natural rubber under planar elongation

Natural rubber exhibits the strain-induced crystallization (SIC). By using WAXD, the orientation of NR crystal formed by SIC under planar elongation was revisited. We found that the orientational state of the crystal lattice possesses a continuous margin of the orientation angle between 6.4 and 19.6° for the ac plane with respect to the surface of the specimen sheet in the real NR specimen. This orientational state could be accomplished as a result of balancing the preferential parallel orientation of (120) planes (the slip planes) and C = C planes with respect to the surface of the specimen sheet.

Ruito Tanaka
Tomohiro Yasui
Shinichi Sakurai
Research17 Apr 2024
Polymer Journal

Volume: 56, P: 753-763
Synergic interaction between ritodrine and magnesium sulfate on the occurrence of critical neonatal hyperkalemia: A Japanese nationwide retrospective cohort study

Yukari Yada
Akihide Ohkuchi
Mariko Hida
ResearchOpen Access08 May 2020
Scientific Reports

Volume: 10, P: 1-13
Effects of drying temperature in solution coating process on the structural changes upon uniaxial stretching of sphere-forming block copolymer films

The correlation between mechanical properties and structural changes upon uniaxial stretching was studied by atomic force microscopy observations and two-dimensional small-angle X-ray scattering measurements. For this purpose, coated layers composed of di- and tri-block copolymer blends were prepared by solution coating at different drying temperatures. The packing regularity of spherical microdomains in the stretching direction was enhanced with stretching. We could correlate fracture of the block copolymer film having spherical microdomains with the completion of stretching-induced ordering of spheres in the stretching direction, which sensitively depended on the drying temperature.

Takahiro Doi
Hideaki Takagi
Shinichi Sakurai
Research02 Dec 2019
Polymer Journal

Volume: 52, P: 421-433

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