Nature Search

p16-mediated G0/G1 cell cycle arrest leads to SASP and fibrosis in Fuchs endothelial corneal dystrophy

Mohit Parekh
Yadav Adhikari
Ula V. Jurkunas
ResearchOpen Access02 Feb 2026
Cell Death & Disease

Volume: 17, P: 1-17
Cultivated autologous limbal epithelial cell (CALEC) transplantation for limbal stem cell deficiency: a phase I/II clinical trial of the first xenobiotic-free, serum-free, antibiotic-free manufacturing protocol developed in the US

Results of a phase I/II clinical trial of CALEC, limbal epithelial cell grafts generated by an innovative and rigorously standardized manufacturing protocol, showing safety and feasibility for treating LSCD.

Ula V. Jurkunas
Aaron R. Kaufman
Jerome Ritz
ResearchOpen Access04 Mar 2025
Nature Communications

Volume: 16, P: 1-12
Clonal selection of hematopoietic stem cells after gene therapy for sickle cell disease

Analysis of hematopoietic stem cells from six individuals with sickle cell disease who had been treated with autologous gene therapy revealed positive selective pressure on cells containing mutations in genes associated with clonal hematopoiesis and hematological malignancies.

Michael Spencer Chapman
Alyssa H. Cull
David G. Kent
ResearchOpen Access16 Nov 2023
Nature Medicine

Volume: 29, P: 3175-3183
Lymphocyte apoptosis: induction by gene transfer techniques

O Ebert
S Finke
IGH Schmidt-Wolf
Research01 Apr 1997
Gene Therapy

Volume: 4, P: 296-302
On-chip recapitulation of clinical bone marrow toxicities and patient-specific pathophysiology

A vascularized human bone-marrow-on-a-chip improves the maintenance of patient-derived CD34⁺ cells, and recapitulates clinically relevant aspects of bone marrow injury as well as key haematopoietic defects of patients with a rare genetic disorder.

David B. Chou
Viktoras Frismantas
Donald E. Ingber
Research27 Jan 2020
Nature Biomedical Engineering

Volume: 4, P: 394-406
Manufacturing Differences Affect Human Bone Marrow Stromal Cell Characteristics and Function: Comparison of Production Methods and Products from Multiple Centers

Shutong Liu
Luis F. de Castro
David F. Stroncek
ResearchOpen Access27 Apr 2017
Scientific Reports

Volume: 7, P: 1-11
p53 is active in murine stem cells and alters the transcriptome in a manner that is reminiscent of mutant p53

H Yan
V Solozobova
C Blattner
ResearchOpen Access26 Feb 2015
Cell Death & Disease

Volume: 6, P: e1662
Sprouty2 inhibits BDNF-induced signaling and modulates neuronal differentiation and survival

I Gross
O Armant
J-P Loeffler
Research29 Jun 2007
Cell Death & Differentiation

Volume: 14, P: 1802-1812

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