Nature Search

Ras-MAP kinase signaling by lysophosphatidic acid and other G protein-coupled receptor agonists

Onno Kranenburg
Wouter H Moolenaar
Reviews26 Mar 2001
Oncogene

Volume: 20, P: 1540-1546
VEGF-C propagates ‘onward’ colorectal cancer metastasis from liver to lung

Susanna Poghosyan
Nicola Frenkel
Jeroen Hagendoorn
Research09 Nov 2024
British Journal of Cancer

Volume: 132, P: 69-80
Targeting the DNA damage response prevents regrowth of colorectal peritoneal metastasis-derived organoids following treatment with mitomycin C

Kyah van Megesen
Arianna Stefan
Onno Kranenburg
ResearchOpen Access05 Jan 2026
British Journal of Cancer

P: 1-12
Quantifying cell divisions along evolutionary lineages in cancer

This work presents a framework for estimating cell division numbers using DNA replication-associated polyguanine tract mutations, with applications for understanding tumor natural histories and origins.

Martin Blohmer
David M. Cheek
Kamila Naxerova
Research04 Feb 2025
Nature Genetics

Volume: 57, P: 706-717
Further characterisation of immortalised human lymphatic endothelial cells to explore their transcriptomic profile and VEGFC response

Kazim Ogmen
Ruby Moy
Silvia Martin-Almedina
ResearchOpen Access13 Dec 2025
Scientific Reports

Volume: 15, P: 1-16
Dual effect of Kras^D12 knockdown on tumorigenesis: increased immune-mediated tumor clearance and abrogation of tumor malignancy

Niels Smakman
Liesbeth M Veenendaal
Onno Kranenburg
Research08 Aug 2005
Oncogene

Volume: 24, P: 8338-8342
Liver lymphatic drainage patterns follow segmental anatomy in a murine model

Nicola C. Frenkel
Susanna Poghosyan
Jeroen Hagendoorn
ResearchOpen Access11 Dec 2020
Scientific Reports

Volume: 10, P: 1-9
Common anti-cancer therapies induce somatic mutations in stem cells of healthy tissue

Specific anti-cancer therapies are highly mutagenic to cancer cells but the mutational impact on healthy tissues remains elusive. Here, the authors use organoids and whole-genome sequencing to characterise somatic mutations in healthy colon and liver adult stem cells after chemo- or radiotherapy.

Ewart Kuijk
Onno Kranenburg
Arne Van Hoeck
ResearchOpen Access07 Oct 2022
Nature Communications

Volume: 13, P: 1-10
Clinical implications of whole genome sequencing in metastatic colorectal cancer

Lidwien P. Smabers
Hilde H. Nienhuis
Jeanine M. L. Roodhart
Research07 Nov 2025
Oncogene

Volume: 44, P: 4686-4698
Molecular characterization of colorectal cancer related peritoneal metastatic disease

Colorectal cancer can lead to the development of peritoneal metastases, which are associated with worse disease outcome. Here, the authors characterize peritoneal metastases from 52 patients using RNA-seq and mutational sequencing and show a distinct molecular subtype.

Kristiaan J. Lenos
Sander Bach
Louis Vermeulen
ResearchOpen Access04 Aug 2022
Nature Communications

Volume: 13, P: 1-14
Stromal localization of inactive CD8⁺ T cells in metastatic mismatch repair deficient colorectal cancer

Emre Küçükköse
Matthijs J. D. Baars
Yvonne Vercoulen
Research02 Dec 2023
British Journal of Cancer

Volume: 130, P: 213-223
Lymph node metastases develop through a wider evolutionary bottleneck than distant metastases

Analysis of metastases using a mathematical framework and multi-region sampling data shows that lymph node metastases have higher levels of intratumor heterogeneity than distant metastases, and that these form via different evolutionary mechanisms.

Johannes G. Reiter
Wei-Ting Hung
Kamila Naxerova
Research25 May 2020
Nature Genetics

Volume: 52, P: 692-700
Ongoing chromosomal instability and karyotype evolution in human colorectal cancer organoids

The authors use three-dimensional live-cell imaging of colorectal carcinoma organoids to show that chromosomal instability is widespread. Single-cell sequencing identifies heterogeneity of copy number alterations and shows clonal evolution.

Ana C. F. Bolhaqueiro
Bas Ponsioen
Geert J. P. L. Kops
Research29 Apr 2019
Nature Genetics

Volume: 51, P: 824-834
KIT promotes tumor stroma formation and counteracts tumor-suppressive TGFβ signaling in colorectal cancer

Emre Küçükköse
Niek A. Peters
Onno Kranenburg
ResearchOpen Access16 Jul 2022
Cell Death & Disease

Volume: 13, P: 1-10
Fibroblast activation protein identifies Consensus Molecular Subtype 4 in colorectal cancer and allows its detection by ⁶⁸Ga-FAPI-PET imaging

Esther Strating
Emma Wassenaar
Onno Kranenburg
ResearchOpen Access16 Mar 2022
British Journal of Cancer

Volume: 127, P: 145-155
Peritoneal metastases from colorectal cancer belong to Consensus Molecular Subtype 4 and are sensitised to oxaliplatin by inhibiting reducing capacity

Jamila Laoukili
Alexander Constantinides
Onno Kranenburg
ResearchOpen Access22 Feb 2022
British Journal of Cancer

Volume: 126, P: 1824-1833
Differential anti-tumour effects of MTH1 inhibitors in patient-derived 3D colorectal cancer cultures

Lizet M. van der Waals
Jamila Laoukili
Onno Kranenburg
ResearchOpen Access28 Jan 2019
Scientific Reports

Volume: 9, P: 1-12
Organoid models of gastrointestinal cancers in basic and translational research

Organoid technology has emerged as a powerful method for studying gastrointestinal cancers. This Review describes organoid models of gastrointestinal cancers, such as colorectal and liver cancer, and discusses how they can be used in basic and translational research in fields such as drug discovery and personalized medicine.

Harry Cheuk Hay Lau
Onno Kranenburg
Jun Yu
Reviews25 Feb 2020
Nature Reviews Gastroenterology & Hepatology

Volume: 17, P: 203-222
Urine-derived bladder cancer organoids (urinoids) as a tool for cancer longitudinal response monitoring and therapy adaptation

Bastiaan J. Viergever
Daniëlle A. E. Raats
Richard P. Meijer
ResearchOpen Access15 Dec 2023
British Journal of Cancer

Volume: 130, P: 369-379
Survival of patients with deficient mismatch repair metastatic colorectal cancer in the pre-immunotherapy era

G. Emerens Wensink
Marloes A. G. Elferink
Miriam Koopman
ResearchOpen Access13 Oct 2020
British Journal of Cancer

Volume: 124, P: 399-406
Surgical implantation of an abdominal imaging window for intravital microscopy

Laila Ritsma
Ernst J A Steller
Jacco van Rheenen
Protocols21 Feb 2013
Nature Protocols

Volume: 8, P: 583-594
NOXA-dependent contextual synthetic lethality of BCL-XL inhibition and “osmotic reprogramming” in colorectal cancer

Gertrud Knoll
Petra Riffelsberger
Martin Ehrenschwender
ResearchOpen Access20 Apr 2020
Cell Death & Disease

Volume: 11, P: 1-11
Associations of non-pedunculated T1 colorectal adenocarcinoma outcome with consensus molecular subtypes, immunoscore, and microsatellite status: a multicenter case-cohort study

Krijn J. C. Haasnoot
Yara Backes
Miangela M. Laclé
Research24 Jun 2020
Modern Pathology

Volume: 33, P: 2626-2636
CD95 ligand induces senescence in mismatch repair-deficient human colon cancer via chronic caspase-mediated induction of DNA damage

Danielle A Raats
Nicola Frenkel
Onno Kranenburg
ResearchOpen Access16 Mar 2017
Cell Death & Disease

Volume: 8, P: e2669
Patient-derived organoids as a predictive biomarker for treatment response in cancer patients

G. Emerens Wensink
Sjoerd G. Elias
Jeanine M. L. Roodhart
ReviewsOpen Access12 Apr 2021
npj Precision Oncology

Volume: 5, P: 1-13

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