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Advanced filters: Author: Oscar J. Nino-Meza Clear advanced filters

¹⁸F-Fluorodeoxysorbitol PET for noninvasive detection of invasive mold infections: preclinical and first-in-human studies

In this study, the authors describe an imaging technology, ¹⁸F-FDS PET, for noninvasive detection, localization and monitoring of invasive mold infections, including Aspergillus, non-Aspergillus and azole-resistant molds, throughout the body.

Carlos E. Ruiz-Gonzalez
Oscar J. Nino-Meza
Sanjay K. Jain
ResearchOpen Access10 Jul 2025
Nature Communications

Volume: 16, P: 1-12
Dynamic PET reveals compartmentalized brain and lung tissue antibiotic exposures of tuberculosis drugs

Antibiotic treatments for tuberculous meningitis, the deadliest form of tuberculosis, are not optimized. Here, PET in human and animal studies is used to measure the biodistribution of several antibiotics to develop optimized regimens for drug-resistant tuberculous meningitis.

Xueyi Chen
Bhavatharini Arun
Sanjay K. Jain
ResearchOpen Access14 Aug 2024
Nature Communications

Volume: 15, P: 1-11
Proapoptotic Bcl-2 inhibitor as potential host directed therapy for pulmonary tuberculosis

Mycobacterium tuberculosis prevents host-cell apoptosis, causing necrosis and fibrosis, leading to tissue damage. Singh et al. show that strategic targeting of apoptosis with Bcl-2 inhibitors may enhance TB treatments and be protective against post-TB lung disease.

Medha Singh
Mona O. Sarhan
Sanjay K. Jain
ResearchOpen Access27 Mar 2025
Nature Communications

Volume: 16, P: 1-13

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