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Showing 1–9 of 9 results
Advanced filters: Author: Oskar Hallatschek Clear advanced filters

  • Based on a combination of experiments and modelling, this study shows large stochastic fluctuations in genotype frequencies caused by intrinsic and extrinsic factors, with implications for population dynamics and evolution.

    • Joao A. Ascensao
    • Kristen Lok
    • Oskar Hallatschek
    Research
    Nature Ecology & Evolution
    Volume: 9, P: 166-179

  • Fitness landscapes largely shape the dynamics of evolution, but it is unclear how they shift upon ecological diversification. By engineering genome-wide knockout libraries of a nascent bacterial community, Ascensao et al. show how ecological and epistatic patterns combine to shape adaptive landscapes.

    • Joao A. Ascensao
    • Kelly M. Wetmore
    • Oskar Hallatschek
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-19

  • Populations of growing yeast are shown to undergo a jamming transition typically observed in gravity-driven granular flows. The pressures generated by intercellular forces are found to be large enough to destroy the cells’ micro-environment.

    • Morgan Delarue
    • Jörn Hartung
    • Oskar Hallatschek
    Research
    Nature Physics
    Volume: 12, P: 762-766

  • Antibiotic and anti-cancer therapy are challenged by mutation-mediated treatment resistance despite many mutations being maladaptive. Here, the authors introduce a system that shows how the probability of the long-term persistence of drug-resistant mutant lineages can be increased in dense microbial populations by acquiring multiple mutations.

    • Serhii Aif
    • Nico Appold
    • Jona Kayser
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12

  • Slower-growing yeast clones at the colony edge have their fitness disadvantage masked by the collective motion of neighbouring cells, reducing the rate at which costly mutations are selected against.

    • Jona Kayser
    • Carl F. Schreck
    • Oskar Hallatschek
    Research
    Nature Ecology & Evolution
    Volume: 3, P: 125-134

  • Large mutant clones arising from early mutations in growing cell populations facilitate short-term evolution in microbes and in tumours. Here the authors analyse spatially expanding colonies, and show that large mutant clones can also arise late when they surf at expanding frontiers.

    • Diana Fusco
    • Matti Gralka
    • Oskar Hallatschek
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-9

  • The genome of the asexual rotifer Adineta vaga lacks homologous chromosomes; instead, its allelic regions are rearranged and sometimes found on the same chromosome in a palindromic fashion, a structure reminiscent of the primate Y chromosome and of other mitotic lineages such as cancer cells.

    • Jean-François Flot
    • Boris Hespeels
    • Karine Van Doninck
    ResearchOpen Access
    Nature
    Volume: 500, P: 453-457

  • Active matter locally dissipates energy to produce systematic motion. This Perspective highlights proliferation as a special type of activity that breaks particle number conservation and thereby gives rise to a unique set of collective phenomena characteristic of life.

    • Oskar Hallatschek
    • Sujit S. Datta
    • Ned S. Wingreen
    Reviews
    Nature Reviews Physics
    Volume: 5, P: 407-419