Nature Search

Northern peatland microbial communities exhibit resistance to warming and acquire electron acceptors from soil organic matter

Climate change is expected to impact microbes degrading organic matter in northern peatlands. Here, using a warming experiment, the authors show that communities remain stable after three years of warming, likely due to metabolic versatility and an ability to obtain electron acceptors from organic matter cleavage.

Katherine Duchesneau
Borja Aldeguer-Riquelme
Joel E. Kostka
ResearchOpen Access25 Jul 2025
Nature Communications

Volume: 16, P: 1-17
Co-Activation of Metabotropic Glutamate Receptor 3 and Beta-Adrenergic Receptors Modulates Cyclic-AMP and Long-Term Potentiation, and Disrupts Memory Reconsolidation

Adam G Walker
Douglas J Sheffler
P Jeffrey Conn
Research30 Jun 2017
Neuropsychopharmacology

Volume: 42, P: 2553-2566
mGluR5 Positive Allosteric Modulators Facilitate both Hippocampal LTP and LTD and Enhance Spatial Learning

Jennifer E Ayala
Yelin Chen
P Jeffrey Conn
Research18 Mar 2009
Neuropsychopharmacology

Volume: 34, P: 2057-2071
Pharmacological Treatments for Autism Spectrum Disorder: Will Emerging Approaches Yield New Treatments?

Rocco G Gogliotti
P Jeffrey Conn
Research10 Dec 2015
Neuropsychopharmacology

Volume: 41, P: 376-377
Promise of mGluR2/3 activators in psychiatry

P Jeffrey Conn
Carrie K Jones
Research12 Dec 2008
Neuropsychopharmacology

Volume: 34, P: 248-249
Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

G protein–coupled receptors (GPCRs) represent one of the most targeted protein families in pharmaceutical research. Traditionally, drug discovery programmes have searched for ligands that act at endogenous orthosteric sites. Here, Conn and colleagues discuss recent advances in the identification of novel GPCR ligands that act at allosteric sites, highlighting their potential in the treatment of psychiatric and neurological disorders.

P. Jeffrey Conn
Arthur Christopoulos
Craig W. Lindsley
Reviews01 Jan 2009
Nature Reviews Drug Discovery

Volume: 8, P: 41-54
mGlu₁ and mGlu₅ modulate distinct excitatory inputs to the nucleus accumbens shell

Brandon D. Turner
Jerri M. Rook
Brad A. Grueter
Research27 Mar 2018
Neuropsychopharmacology

Volume: 43, P: 2075-2082
Partial mGlu₅ Negative Allosteric Modulators Attenuate Cocaine-Mediated Behaviors and Lack Psychotomimetic-Like Effects

Robert W Gould
Russell J Amato
Carrie K Jones
Research28 Aug 2015
Neuropsychopharmacology

Volume: 41, P: 1166-1178
New Guinea has the world’s richest island flora

A catalogue of the vascular flora of New Guinea indicates that this island is the most floristically diverse in the world, and that 68% of the species identified are endemic to New Guinea.

Rodrigo Cámara-Leret
David G. Frodin
Peter C. van Welzen
Research05 Aug 2020
Nature

Volume: 584, P: 579-583
An allosteric potentiator of M₄ mAChR modulates hippocampal synaptic transmission

Jana K Shirey
Zixiu Xiang
P Jeffrey Conn
Research02 Dec 2007
Nature Chemical Biology

Volume: 4, P: 42-50
Opportunities and challenges in the discovery of allosteric modulators of GPCRs for treating CNS disorders

G protein-coupled receptors (GPCRs) are highly successful drug targets, particularly for central nervous system (CNS) disorders. Compared to traditional drugs that target the orthosteric ligand-binding site of GPCRs, allosteric modulators have the potential to achieve greater subtype selectivity and allow the normal function of endogenous ligands to be preserved. Conn and colleagues reflect on the key principles for successful optimization of GPCR allosteric modulators.

P. Jeffrey Conn
Craig W. Lindsley
Colleen M. Niswender
Reviews01 Sept 2014
Nature Reviews Drug Discovery

Volume: 13, P: 692-708
Relationship between In Vivo Receptor Occupancy and Efficacy of Metabotropic Glutamate Receptor Subtype 5 Allosteric Modulators with Different In Vitro Binding Profiles

Jerri M Rook
Mohammed N Tantawy
P Jeffrey Conn
Research22 Sept 2014
Neuropsychopharmacology

Volume: 40, P: 755-765
mGlu₁-mediated restoration of prefrontal cortex inhibitory signaling reverses social and cognitive deficits in an NMDA hypofunction model in mice

Deborah J. Luessen
Isabel M. Gallinger
P. Jeffrey Conn
Research28 May 2022
Neuropsychopharmacology

Volume: 47, P: 1826-1835
Metabotropic glutamate receptors in the basal ganglia motor circuit

P. Jeffrey Conn
Giuseppe Battaglia
Ferdinando Nicoletti
Reviews01 Oct 2005
Nature Reviews Neuroscience

Volume: 6, P: 787-798
Effects of short-term quetiapine and lithium therapy for acute manic or mixed episodes on the limbic system and emotion regulation circuitry in youth with bipolar disorder

Du Lei
Wenbin Li
Melissa P. DelBello
Research13 Oct 2022
Neuropsychopharmacology

Volume: 48, P: 615-622
Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes

A large-scale genetic analysis of type 1 diabetes identifies new susceptibility variants, highlights potential regulatory mechanisms and provides genetic support for therapeutic targets for immune intervention.

Catherine C. Robertson
Jamie R. J. Inshaw
Stephen S. Rich
Research14 Jun 2021
Nature Genetics

Volume: 53, P: 962-971
M₁-positive allosteric modulators lacking agonist activity provide the optimal profile for enhancing cognition

Sean P. Moran
Jonathan W. Dickerson
P. Jeffrey Conn
Research14 Mar 2018
Neuropsychopharmacology

Volume: 43, P: 1763-1771
Bringing together the academic drug discovery community

Barbara S. Slusher
P. Jeffrey Conn
Michelle Arkin
Comments & Opinion31 Oct 2013
Nature Reviews Drug Discovery

Volume: 12, P: 811-812
Leveraging bias to your advantage

Characterization of biased receptor signaling has ushered in opportunities for unprecedented control of G-protein-coupled receptors. Elucidation of distinct M1 muscarinic acetylcholine receptor signaling pathways and development of biased ligands may offer novel and safer Alzheimer’s disease therapeutics.

Sean P. Moran
P. Jeffrey Conn
News & Views20 Feb 2020
Nature Chemical Biology

Volume: 16, P: 226-227
Potentiation of M₁ Muscarinic Receptor Reverses Plasticity Deficits and Negative and Cognitive Symptoms in a Schizophrenia Mouse Model

A Ghoshal
J M Rook
P J Conn
Research25 Jun 2015
Neuropsychopharmacology

Volume: 41, P: 598-610
An open science resource for establishing reliability and reproducibility in functional connectomics

Xi-Nian Zuo
Jeffrey S Anderson
Michael P Milham
ResearchOpen Access09 Dec 2014
Scientific Data

Volume: 1, P: 1-13
Shank3 modulates Rpl3 expression and protein synthesis via mGlu5: implications for Phelan McDermid syndrome

Federica Giona
Stefania Beretta
Chiara Verpelli
ResearchOpen Access15 Mar 2025
Molecular Psychiatry

Volume: 30, P: 3599-3614
Frontal cortex genetic ablation of metabotropic glutamate receptor subtype 3 (mGlu₃) impairs postsynaptic plasticity and modulates affective behaviors

Max E. Joffe
Chiaki I. Santiago
P. Jeffrey Conn
Research25 May 2021
Neuropsychopharmacology

Volume: 46, P: 2148-2157
Reversal of the diabetic bone signature with anabolic therapies in mice

Silvia Marino
Nisreen Akel
Teresita Bellido
ResearchOpen Access19 Apr 2023
Bone Research

Volume: 11, P: 1-12
Activation of the mGlu₁ metabotropic glutamate receptor has antipsychotic-like effects and is required for efficacy of M₄ muscarinic receptor allosteric modulators

Samantha E. Yohn
Daniel J. Foster
P. Jeffrey Conn
Research16 Aug 2018
Molecular Psychiatry

Volume: 25, P: 2786-2799
Tackling reproducibility in academic preclinical drug discovery

The reproducibility of biomedical research on novel drug targets has become suspect. Here, we highlight how drug discovery centres embedded in academic institutions, but with a translational imperative, can help address this reproducibility crisis.

Stephen V. Frye
Michelle R. Arkin
Barbara S. Slusher
Comments & Opinion21 Sept 2015
Nature Reviews Drug Discovery

Volume: 14, P: 733-734
Antipsychotic Drug-Like Effects of the Selective M₄ Muscarinic Acetylcholine Receptor Positive Allosteric Modulator VU0152100

Nellie E Byun
Michael Grannan
Carrie K Jones
Research20 Jan 2014
Neuropsychopharmacology

Volume: 39, P: 1578-1593
Metabotropic glutamate receptor subtype 3 gates acute stress-induced dysregulation of amygdalo-cortical function

Max E. Joffe
Chiaki I. Santiago
P. Jeffrey Conn
Research21 Dec 2017
Molecular Psychiatry

Volume: 24, P: 916-927
The mGluR2 Positive Allosteric Modulator BINA Decreases Cocaine Self-Administration and Cue-Induced Cocaine-Seeking and Counteracts Cocaine-Induced Enhancement of Brain Reward Function in Rats

Xinchun Jin
Svetlana Semenova
Athina Markou
Research16 Jun 2010
Neuropsychopharmacology

Volume: 35, P: 2021-2036
An mGlu₅-Positive Allosteric Modulator Rescues the Neuroplasticity Deficits in a Genetic Model of NMDA Receptor Hypofunction in Schizophrenia

Darrick T Balu
Yan Li
Joseph T Coyle
Research07 Jan 2016
Neuropsychopharmacology

Volume: 41, P: 2052-2061
Modulation of arousal and sleep/wake architecture by M₁ PAM VU0453595 across young and aged rodents and nonhuman primates

Robert W. Gould
Jason K. Russell
Carrie K. Jones
Research31 Aug 2020
Neuropsychopharmacology

Volume: 45, P: 2219-2228
Inhibition of endocannabinoid degradation rectifies motivational and dopaminergic deficits in the Q175 mouse model of Huntington’s disease

Dan P. Covey
Hannah M. Dantrassy
Joseph F. Cheer
Research01 Jun 2018
Neuropsychopharmacology

Volume: 43, P: 2056-2063
AI is a viable alternative to high throughput screening: a 318-target study

Izhar Wallach
Denzil Bernard
Abraham Heifets
ResearchOpen Access02 Apr 2024
Scientific Reports

Volume: 14, P: 1-16
Opportunities and Challenges of Psychiatric Drug Discovery: Roles for Scientists in Academic, Industry, and Government Settings

P Jeffrey Conn
Bryan L Roth
Research23 Jan 2008
Neuropsychopharmacology

Volume: 33, P: 2048-2060
M₁ and M₃ muscarinic receptors may play a role in the neurotoxicity of anhydroecgonine methyl ester, a cocaine pyrolysis product

Raphael Caio Tamborelli Garcia
Livia Mendonça Munhoz Dati
Tania Marcourakis
ResearchOpen Access02 Dec 2015
Scientific Reports

Volume: 5, P: 1-12
Antidepressant potential of metabotropic glutamate receptor mGlu₂ and mGlu₃ negative allosteric modulators

Max E. Joffe
P. Jeffrey Conn
Research10 Sept 2018
Neuropsychopharmacology

Volume: 44, P: 214-236
Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk

Richard Houlston and colleagues report a genome-wide association study for colorectal cancer. They report three loci newly associated with colorectal cancer, bringing the total number of common susceptibility loci to 20.

Malcolm G Dunlop
Sara E Dobbins
Richard S Houlston
Research27 May 2012
Nature Genetics

Volume: 44, P: 770-776
Erratum: Opportunities and Challenges of Psychiatric Drug Discovery: Roles for Scientists in Academic, Industry, and Government Settings

P Jeffrey Conn
Bryan L Roth
Amendments and Corrections04 Jun 2008
Neuropsychopharmacology

Volume: 33, P: 2300
Roles of serine/threonine phosphatases in hippocampel synaptic plasticity

Danny G. Winder
J. David Sweatt
Reviews01 Jul 2001
Nature Reviews Neuroscience

Volume: 2, P: 461-474
Changes in BQCA Allosteric Modulation of [³H]NMS Binding to Human Cortex within Schizophrenia and by Divalent Cations

Brian Dean
Shaun Hopper
Elizabeth Scarr
Research29 Oct 2015
Neuropsychopharmacology

Volume: 41, P: 1620-1628
Neurotherapeutics

Gwenn S Smith
Xiaohua Li
P Jeffrey Conn
Editorial13 Dec 2011
Neuropsychopharmacology

Volume: 37, P: 1-3
Author Correction: AI is a viable alternative to high throughput screening: a 318-target study

Izhar Wallach
Denzil Bernard
Ellie Giles
Amendments and CorrectionsOpen Access16 Sept 2024
Scientific Reports

Volume: 14, P: 1-2

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