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Showing 1–50 of 55 results

Advanced filters: Author: P. Pyl Clear advanced filters

New codons for efficient production of unnatural proteins in a semisynthetic organism

Systematic characterization of codons using the unnatural base pair dNaM·dTPT3 leads to the discovery of nine new functional codon–anticodon pairs, three of which are shown to be orthogonally decoded by ribosomes and allow incorporation of up to three noncanonical amino acids in Escherichia coli.

Emil C. Fischer
Koji Hashimoto
Floyd E. Romesberg
Research06 Apr 2020
Nature Chemical Biology

Volume: 16, P: 570-576
Recoding of stop codons expands the metabolic potential of two novel Asgardarchaeota lineages

Jiarui Sun
Paul N. Evans
Christian Rinke
ResearchOpen Access28 Jun 2021
ISME Communications

Volume: 1, P: 1-14
Live Cell Imaging of Bioorthogonally Labelled Proteins Generated With a Single Pyrrolysine tRNA Gene

Noa Aloush
Tomer Schvartz
Eyal Arbely
ResearchOpen Access28 Sept 2018
Scientific Reports

Volume: 8, P: 1-11
A genetic network mediating the control of bud break in hybrid aspen

Molecular mechanism of how temperature-mediated control of bud break in perennial plants remains unclear. Here, the author show that transcriptional factor SHORT VEGETATIVE PHASE-LIKE and its downstream target TCP18 are negative regulators of hybrid aspen bud break.

Rajesh Kumar Singh
Jay P. Maurya
Rishikesh P. Bhalerao
ResearchOpen Access09 Oct 2018
Nature Communications

Volume: 9, P: 1-10
Selecting aminoacyl-tRNA synthetase/tRNA pairs for efficient genetic encoding of noncanonical amino acids into proteins

Mehl and colleagues present a protocol for selecting aminoacyl-tRNA synthetase (RS)/tRNA pairs from a publicly available MaPylRS active site mutant library for specific and efficient incorporation of noncanonical amino acids into proteins.

Nathan D. Alexander
Yogesh M. Gangarde
Ryan A. Mehl
Protocols22 Sept 2025
Nature Protocols

P: 1-55
Spontaneous and specific chemical cross-linking in live cells to capture and identify protein interactions

Proteins associate via weak and transient interactions that are challenging to identify in vivo. Here, the authors use a genetically encoded chemical cross-linker to covalently lock interacting proteins in live cells, allowing them to identify the captured proteins by mass spectrometry.

Bing Yang
Shibing Tang
Lei Wang
ResearchOpen Access21 Dec 2017
Nature Communications

Volume: 8, P: 1-10
A robust platform streamlining aromatic noncanonical amino acid biosynthesis and genetic code expansion in Escherichia coli

Genetic code expansion (GCE) has expanded protein functionality, but the cost of noncanonical amino acids (ncAAs) hinder large-scale use. Here, the authors coupled amino acid biosynthesis with GCE in E. coli for the production of ncAA-containing biomolecules.

Jingxuan Zhang
Keying Yu
Cangsong Liao
ResearchOpen Access29 Sept 2025
Nature Communications

Volume: 16, P: 1-13
Switchable genome editing via genetic code expansion

Toru Suzuki
Maki Asami
Anthony C. F. Perry
ResearchOpen Access03 Jul 2018
Scientific Reports

Volume: 8, P: 1-12
Augmented genetic decoding: global, local and temporal alterations of decoding processes and codon meaning

There is accumulating evidence that the genetic code is not fixed but instead varies across organisms and that decoding is influenced by genomic and physiological contexts. This Review describes the various types of non-standard decoding, including altered codon meanings and ribosomal frameshifting, and highlights their pervasiveness, classification and biological implications.

Pavel V. Baranov
John F. Atkins
Martina M. Yordanova
Reviews11 Aug 2015
Nature Reviews Genetics

Volume: 16, P: 517-529
A plant NLR receptor employs ABA central regulator PP2C-SnRK2 to activate antiviral immunity

Huang et al. show how plant Sw-5b NLR mimics the ABA receptor to activate ABA-dependent antiviral immunity via the PP2C-SnRK2 complex. They reveal that Sw-5b NLR induces ABA accumulation, upregulates ABA response genes, and triggers defense against viral infections by releasing SnRK2 from PP2C inhibition.

Shen Huang
Chunli Wang
Xiaorong Tao
ResearchOpen Access13 Apr 2024
Nature Communications

Volume: 15, P: 1-14
Root hydrotropism is controlled via a cortex-specific growth mechanism

Roots bend towards water. The root cortex in the elongation zone is the site of perception during hydrotropism but also the site of differential root growth, which is different from gravitropism.

Daniela Dietrich
Lei Pang
Malcolm J. Bennett
Research08 May 2017
Nature Plants

Volume: 3, P: 1-8
The effect of positioning cations on acidity and stability of the framework structure of Y zeolite

Changshun Deng
Junji Zhang
Yanjun Gong
ResearchOpen Access18 Mar 2016
Scientific Reports

Volume: 6, P: 1-13
Structure determination and activity manipulation of the turfgrass ABA receptor FePYR1

Zhizhong Ren
Zhen Wang
Jian-Kang Zhu
ResearchOpen Access25 Oct 2017
Scientific Reports

Volume: 7, P: 1-13
Trapping biosynthetic acyl-enzyme intermediates with encoded 2,3-diaminopropionic acid

A method for encoding the non-canonical amino acid 2,3-diaminopropionate into proteins allows key acyl intermediates in the biosynthesis of valinomycin to be trapped, providing insight into the oligomerization and cyclization reactions involved.

Nicolas Huguenin-Dezot
Diego A. Alonzo
Jason W. Chin
Research12 Dec 2018
Nature

Volume: 565, P: 112-117
RF1 knockout allows ribosomal incorporation of unnatural amino acids at multiple sites

Nonsense suppression, or reassigning stop codons to encode for other amino acids, offers a method for expanding the genetic code of proteins. Deletion of release factor 1 in an Escherichia coli strain enables the incorporation of non-natural amino acids into proteins at multiple sites.

David B F Johnson
Jianfeng Xu
Lei Wang
Research18 Sept 2011
Nature Chemical Biology

Volume: 7, P: 779-786
The HAB1 PP2C is inhibited by ABA-dependent PYL10 interaction

Juan Li
Chaowei Shi
Changlin Tian
ResearchOpen Access05 Jun 2015
Scientific Reports

Volume: 5, P: 1-11
Environmental gradients reveal stress hubs pre-dating plant terrestrialization

Dadras et al. exposed Mesotaenium, an alga of the sister lineage to land plants, to a bifactorial gradient of environmental cues and use comparative analyses to pinpoint conserved circuits in plant genetic response networks.

Armin Dadras
Janine M. R. Fürst-Jansen
Jan de Vries
ResearchOpen Access28 Aug 2023
Nature Plants

Volume: 9, P: 1419-1438
Lymph node targeted multi-epitope subunit vaccine promotes effective immunity to EBV in HLA-expressing mice

There is a clinical need for effective and efficacious vaccines for Epstein-Barr virus (EBV) that induce substantive and protective immunity. Here the authors use a combined lymph-node targeted adjuvant and subunit vaccine against EBV and show the induction and effectiveness in a human leukocyte antigen expressing murine model.’

Vijayendra Dasari
Lisa K. McNeil
Rajiv Khanna
ResearchOpen Access08 Aug 2023
Nature Communications

Volume: 14, P: 1-17
Genomes of multicellular algal sisters to land plants illuminate signaling network evolution

Genome assemblies of four filamentous Zygnematophyceae and co-expression network analyses shed light on the evolutionary roots of the mechanism for balancing environmental responses and multicellular growth.

Xuehuan Feng
Jinfang Zheng
Yanbin Yin
ResearchOpen Access01 May 2024
Nature Genetics

Volume: 56, P: 1018-1031
Effect of Ligaturing on Puparium Formation in the Larva of the Tsetse Fly, Glossina morsitans Westwood

P. A. LANGLEY
Research22 Apr 1967
Nature

Volume: 214, P: 389-390
Amplification of early drought responses caused by volatile cues emitted from neighboring tea plants

Jieyang Jin
Mingyue Zhao
Chuankui Song
ResearchOpen Access15 Nov 2021
Horticulture Research

Volume: 8, P: 1-12
Comparison of Techniques for the Isolation of T-strain Mycoplasmas

D. TAYLOR-ROBINSON
JEAN P. ADDEY
C. S. GOODWIN
Research19 Apr 1969
Nature

Volume: 222, P: 274-275
Transcriptional analysis reveals key insights into seasonal induced anthocyanin degradation and leaf color transition in purple tea (Camellia sinensis (L.) O. Kuntze)

Tony Kipkoech Maritim
Mamta Masand
Ram Kumar Sharma
ResearchOpen Access13 Jan 2021
Scientific Reports

Volume: 11, P: 1-14
Development of Transplanted Imaginal Disks in X-irradiated Housefly Pupae

G. BHASKARAN
P. SIVASUBRAMANIAN
Research24 May 1969
Nature

Volume: 222, P: 786-787
Virtual 2-D map of the fungal proteome

Tapan Kumar Mohanta
Awdhesh Kumar Mishra
Ahmed Al-Harrasi
ResearchOpen Access23 Mar 2021
Scientific Reports

Volume: 11, P: 1-13
Comparative transcriptomic analysis reveals the roles of overlapping heat-/drought-responsive genes in poplars exposed to high temperature and drought

Jingbo Jia
Jing Zhou
Zhi-Bin Luo
ResearchOpen Access24 Feb 2017
Scientific Reports

Volume: 7, P: 1-17
Ultrasmall targeted nanoparticles with engineered antibody fragments for imaging detection of HER2-overexpressing breast cancer

One of the major obstacles in nanoparticle-based therapy is to achieve tumour targeting, limiting non-specific accumulation of the nanoparticles. Here the authors propose the conjugation of anti-HER2 scFv fragments to the silica nanoparticles, increasing specificity and limiting the final size of the immunoconjugates below the renal clearance threshold.

Feng Chen
Kai Ma
Michelle S. Bradbury
ResearchOpen Access08 Oct 2018
Nature Communications

Volume: 9, P: 1-11
HDAC3 mediates retinal endothelial cell metabolic reprogramming and angiogenesis

Christian D. Mitchell
Carol A. Morris
Esraa Shosha
Research29 Sept 2025
Acta Pharmacologica Sinica

P: 1-12
Genetic code expansion in the mouse brain

Adeno-associated viral delivery of an orthogonal tRNA synthetase-tRNA system enables the encoded incorporation of non-natural amino acids into proteins in neuronal cells, in brain slices and in living mice.

Russell J Ernst
Toke P Krogager
Jason W Chin
Research29 Aug 2016
Nature Chemical Biology

Volume: 12, P: 776-778
Involvement of abscisic acid-responsive element-binding factors in cassava (Manihot esculenta) dehydration stress response

Ren-Jun Feng
Meng-Yun Ren
Jiang-Hui Xie
ResearchOpen Access02 Sept 2019
Scientific Reports

Volume: 9, P: 1-12
The Core Subunit of A Chromatin-Remodeling Complex, ZmCHB101, Plays Essential Roles in Maize Growth and Development

Xiaoming Yu
Lili Jiang
Bao Liu
ResearchOpen Access05 Dec 2016
Scientific Reports

Volume: 6, P: 1-13
Amplification of a gene encoding a p53-associated protein in human sarcomas

J. D. Oliner
K. W. Kinzler
B. Vogelstein
Research02 Jul 1992
Nature

Volume: 358, P: 80-83
Evidence for selection following perturbation of allozyme frequencies in a natural population of Drosophila

J. S. F. Barker
P. D. East
Research13 Mar 1980
Nature

Volume: 284, P: 166-168
In silico characterization, physiochemical analysis, and antifungal evaluation of the Zea mays PR-1 protein

Muhammad Zafar Saleem
Zaher Uddin Babar
Ibrahim A. Alaraidh
ResearchOpen Access27 Aug 2025
Scientific Reports

Volume: 15, P: 1-18
Transcriptome analyses revealed molecular responses of Cynanchum auriculatum leaves to saline stress

Ming Zhang
Li-Zhou Hong
Gen Zhang
ResearchOpen Access16 Jan 2020
Scientific Reports

Volume: 10, P: 1-11
The interaction between miR160 and miR165/166 in the control of leaf development and drought tolerance in Arabidopsis

Tianxiao Yang
Yongyan Wang
Guiliang Tang
ResearchOpen Access26 Feb 2019
Scientific Reports

Volume: 9, P: 1-13
Theory of the nuclear optical potential

P. E. Hodgson
News & Views01 Jan 1975
Nature

Volume: 253, P: 163-164
Grafting cucumber onto luffa improves drought tolerance by increasing ABA biosynthesis and sensitivity

Shanshan Liu
Hao Li
Yanhong Zhou
ResearchOpen Access02 Feb 2016
Scientific Reports

Volume: 6, P: 1-14
Central amygdala micro-circuits mediate fear extinction

The central amygdala inhibitory microcircuits mediate fear extinction by reversible, stimulus- and context-specific changes in neuronal responses. These alterations are absent when extinction is deficient and selective silencing of PKCδ neurons impairs fear extinction.

Nigel Whittle
Jonathan Fadok
Stéphane Ciocchi
ResearchOpen Access06 Jul 2021
Nature Communications

Volume: 12, P: 1-11
Homozygous carriers of the TCF7L2 rs7903146 T-allele show altered postprandial response in triglycerides and triglyceride-rich lipoproteins

L. Engelbrechtsen
T. H. Hansen
H. Vestergaard
ResearchOpen Access21 Feb 2017
Scientific Reports

Volume: 7, P: 1-8
Comparative transcriptome and metabolome analysis reveals the differential response to salinity stress of two genotypes brewing sorghum

Wei Zhou
Zhen Guo Wang
Ya Xing Zhou
ResearchOpen Access27 Jan 2025
Scientific Reports

Volume: 15, P: 1-11
Fickian yet non-Gaussian diffusion of a quasi-2D colloidal system in an optical speckle field: experiment and simulations

Antonio Ciarlo
Raffaele Pastore
Giuseppe Pesce
ResearchOpen Access06 May 2023
Scientific Reports

Volume: 13, P: 1-13
Poly(ADP-ribose)-binding protein RCD1 is a plant PARylation reader regulated by Photoregulatory Protein Kinases

Transcriptional regulation in plants through RADICAL-INDUCED CELL DEATH1 (RCD1) is controlled via its N-terminal domains and inhibitory phosphorylation by photoregulatory protein kinases (PPKs).

Julia P. Vainonen
Richard Gossens
Jaakko Kangasjärvi
ResearchOpen Access19 Apr 2023
Communications Biology

Volume: 6, P: 1-10
Differential regulation of triterpene biosynthesis induced by an early failure in cuticle formation in apple

Luigi Falginella
Christelle M. Andre
Richard V. Espley
ResearchOpen Access01 Apr 2021
Horticulture Research

Volume: 8, P: 1-15
The impact of diabetes mellitus on survival following resection and adjuvant chemotherapy for pancreatic cancer

Jörg Kleeff
Eithne Costello
John P Neoptolemos
ResearchOpen Access01 Sept 2016
British Journal of Cancer

Volume: 115, P: 887-894
Three-dimensional organization of pyrrolo[3,2-b]pyrrole-based triazine framework using nanostructural spherical carbon: enhancing electrochemical performance of materials for supercapacitors

Agnieszka Hryniewicka
Joanna Breczko
Marta E. Plonska-Brzezinska
ResearchOpen Access03 Jul 2023
Scientific Reports

Volume: 13, P: 1-14
Photochemical efficiency correlated with candidate gene expression promote coffee drought tolerance

Meline de Oliveira Santos
Larissa Sousa Coelho
Vânia Aparecida Silva
ResearchOpen Access01 Apr 2021
Scientific Reports

Volume: 11, P: 1-14
117 Neurological follow-up at 9 years of normal, suspect and abnormal newborns

P Dijkshoorn
M Hadders-Algra
H J Huisjes
Research01 Oct 1986
Pediatric Research

Volume: 20, P: 1053
Simulated herbivory in chickpea causes rapid changes in defense pathways and hormonal transcription networks of JA/ethylene/GA/auxin within minutes of wounding

Saurabh Prakash Pandey
Shruti Srivastava
Aniruddha P. Sane
ResearchOpen Access16 Mar 2017
Scientific Reports

Volume: 7, P: 1-14
A Potential Role for Adenosine in the Inhibition of Nonshivering Thermogenesis in the Fetal Sheep

K T Ball
T R Gunn
P D Gluckman
Research01 Mar 1995
Pediatric Research

Volume: 37, P: 303-309

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