More than 40 different neurological diseases are caused by microsatellite repeat expansions. Repeat-associated non-AUG (RAN) proteins are translated from different types of nucleotide repeat expansions. The authors review the pathological and molecular aspects of RAN protein accumulation for each RAN translation disorder, the correlation between disease pathology, the available in vivo models and the common features shared by some of the newly discovered RAN proteins.
- Monica Banez-Coronel
- Laura P. W. Ranum
