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Showing 1–4 of 4 results
Advanced filters: Author: Patricia Z. Musacchio Clear advanced filters

  • Covalent inhibitors are powerful entities in drug discovery. Now the amino acid selectivity and reactivity of a diverse electrophile library have been assessed proteome-wide using an unbiased workflow. This comparative analysis and the probes described could help guide the discovery and design of covalent ligands targeting residues beyond cysteine.

    • Patrick R. A. Zanon
    • Fengchao Yu
    • Stephan M. Hacker
    ResearchOpen Access
    Nature Chemistry
    Volume: 17, P: 1712-1721

  • Post-translational modification of proteins is widely used for studying biological processes; however, competing reactions can provide numerous challenges. Now, a visible-light photocatalytic diselenide contraction enables the highly chemoselective functionalization of selenopeptides and proteins under mild conditions.

    • Nicholas A. Fitzpatrick
    • Patricia Z. Musacchio
    News & Views
    Nature Chemistry
    Volume: 15, P: 163-164