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Showing 1–7 of 7 results
Advanced filters: Author: Patrick R. A. Zanon Clear advanced filters

  • Covalent inhibitors are powerful entities in drug discovery. Now the amino acid selectivity and reactivity of a diverse electrophile library have been assessed proteome-wide using an unbiased workflow. This comparative analysis and the probes described could help guide the discovery and design of covalent ligands targeting residues beyond cysteine.

    • Patrick R. A. Zanon
    • Fengchao Yu
    • Stephan M. Hacker
    ResearchOpen Access
    Nature Chemistry
    Volume: 17, P: 1712-1721

  • Patrick Sulem, Daniel Gudbjartsson, Bragi Walters and colleagues identify two low-frequency variants associated with serum uric acid levels and gout in the Icelandic population. The variants were discovered by whole-genome sequencing and are associated with two- to threefold differences in disease risk.

    • Patrick Sulem
    • Daniel F Gudbjartsson
    • Kari Stefansson
    Research
    Nature Genetics
    Volume: 43, P: 1127-1130

  • Hilma Holm et al. report a rare missense variant MYH6 that is associated with a high risk of sick sinus syndrome in Icelanders. This heart condition is found most often in elderly people and is the most frequent reason a heart pacemaker is implanted.

    • Hilma Holm
    • Daniel F Gudbjartsson
    • Kari Stefansson
    Research
    Nature Genetics
    Volume: 43, P: 316-320

  • Thorunn Rafnar and colleagues identify a variant on 4p16.3 near FGFR3 associated with increased risk of urinary bladder cancer. They find that the risk allele is more frequent among individuals with tumors that carry an activating somatic mutation in FGFR3, suggesting a link between germline variation, somatic mutation status and cancer risk.

    • Lambertus A Kiemeney
    • Patrick Sulem
    • Kari Stefansson
    Research
    Nature Genetics
    Volume: 42, P: 415-419

  • Volatile gas emissions measurements indicate the 2021 Cumbre Vieja eruption was one of the most CO2-rich ever measured and suggest that alkaline magmatism over the lifetime of ocean island complexes could emit CO2 at a scale comparable to large igneous provinces

    • Mike Burton
    • Alessandro Aiuppa
    • Nemesio M. Pérez
    ResearchOpen Access
    Communications Earth & Environment
    Volume: 4, P: 1-10