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Showing 1–20 of 20 results
Advanced filters: Author: Paul J. Tesar Clear advanced filters

  • Oligodendrocytes are vulnerable to chemical toxicity during development. However, few environmental chemicals have been identified as potential hazards. Here, the authors discover chemicals in common household products as harmful to oligodendrocyte development.

    • Erin F. Cohn
    • Benjamin L. L. Clayton
    • Paul J. Tesar
    Research
    Nature Neuroscience
    Volume: 27, P: 836-845

  • Astrocytes have important roles in disease. However, modulation of their reactive state is challenging. Here the authors present a phenotypic in vitro screening platform they can leverage to identify chemical compounds able to modulate astrocyte reactivity in vitro and in vivo.

    • Benjamin L. L. Clayton
    • James D. Kristell
    • Paul J. Tesar
    Research
    Nature Neuroscience
    Volume: 27, P: 656-665

  • A study describes the split integrated stress response, a cellular stress response mechanism characterized by reduced eIF2B activity without eIF2α phosphorylation, which activates the eIF4E–ATF4–PCK2 axis, enabling metabolic reprogramming.

    • Chien-Wen Chen
    • David Papadopoli
    • Maria Hatzoglou
    ResearchOpen Access
    Nature
    Volume: 641, P: 1319-1328

  • Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare inflammatory disorder characterised by asthma, eosinophilia and vasculitis. Here, the authors describe a genome-wide association study of EGPA that reveals clinical and genetic differences between subgroups stratified by autoantibody status (ANCA).

    • Paul A Lyons
    • James E Peters
    • Kenneth G. C. Smith
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • In a mouse model of the leukodystrophy Pelizaeus–Merzbacher disease, myelination, motor performance, respiratory function and lifespan are improved by suppressing proteolipid protein expression, suggesting PLP1 as a therapeutic target for human patients with this disease and, more broadly, antisense oligonucleotides as a pharmaceutical modality for treatment of myelin disorders.

    • Matthew S. Elitt
    • Lilianne Barbar
    • Paul J. Tesar
    Research
    Nature
    Volume: 585, P: 397-403

  • A method for generating cortical spheroids from human pluripotent stem cells produces maturing oligodendrocytes that can myelinate axons and model myelin disease and drug effects.

    • Mayur Madhavan
    • Zachary S. Nevin
    • Paul J. Tesar
    Research
    Nature Methods
    Volume: 15, P: 700-706

  • The isolation and propagation of oligodendroglial cells from postnatal animals can be impractical for functional genetic studies. This study highlights the potential of a new approach to rapidly generate oligodendrocytes and their progenitors from mouse embryonic and induced pluripotent stem cells, independent of mouse strain or mutational status.

    • Angela M. Lager
    • Olivia G. Corradin
    • Paul J. Tesar
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-8

  • A new strategy for isolating oligodendrocyte progenitor cells from the human brain may advance the goal of therapeutic remyelination.

    • Robert H Miller
    • Paul J Tesar
    News & Views
    Nature Biotechnology
    Volume: 29, P: 881-883

  • An in vivo RNA interference screening strategy in glioblastoma enabled the identification of a host of epigenetic targets required for glioblastoma cell survival that were not identified by parallel standard screening in cell culture, including the transcription pause–release factor JMJD6, and could be a powerful tool to uncover new therapeutic targets in cancer.

    • Tyler E. Miller
    • Brian B. Liau
    • Jeremy N. Rich
    Research
    Nature
    Volume: 547, P: 355-359

  • Membranous nephropathy (MN) is a rare autoimmune disease of podocyte-directed antibodies, such as anti-phospholipase A2 receptor. Here, the authors report a genome-wide association study for MN and identify two previously unreported loci encompassing the NFKB1 and IRF4 genes and additional ancestry-specific effects.

    • Jingyuan Xie
    • Lili Liu
    • Krzysztof Kiryluk
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-18

  • Mouse and human embryonic stem (ES) cells use different signalling pathways to maintain their pluripotent status. Now, a new kind of pluripotent ES cell is described. This cell type is derived from mouse embryos after they implant in the wall of the uterus, and shares many defining features with human ES cells, including signalling responses that control differentiation to somatic fates.

    • Paul J. Tesar
    • Josh G. Chenoweth
    • Ronald D. G. McKay
    Research
    Nature
    Volume: 448, P: 196-199

  • Which vapors are responsible for new particle formation in the Arctic is largely unknown. Here, the authors show that the formation of new particles at the central Arctic Ocean is mainly driven by iodic acid and that particles smaller than 30 nm in diameter can activate as cloud condensation nuclei.

    • Andrea Baccarini
    • Linn Karlsson
    • Julia Schmale
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11

  • Single-cell or single-nucleus RNA-sequencing experiments form a basis for biological insights about cell types and states, but they require orthogonal experiments to confirm the functional relevance of their findings. Here the authors discuss options to support such findings and their challenges.

    • Marco Colonna
    • Genevieve Konopka
    • Naomi Habib
    Reviews
    Nature Neuroscience
    Volume: 27, P: 2310-2325