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Showing 1–11 of 11 results
Advanced filters: Author: Paul Moayyedi Clear advanced filters

  • PPIs are one of the most commonly prescribed drugs worldwide. However, it has been suggested that PPIs are associated with an increased risk of pneumonia, bone fractures and enteric infections, and that they interact with clopidogrel. In this Review, Paul Moayyedi and Grigorios Leontiadis detail how the evidence supporting these associations is limited, but suggest that PPIs are only given to patients for whom these drugs have been proven beneficial.

    • Paul Moayyedi
    • Grigorios I. Leontiadis
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 9, P: 132-139

  • Here the authors provide an explanation for 95% of examined predicted loss of function variants found in disease-associated haploinsufficient genes in the Genome Aggregation Database (gnomAD), underscoring the power of the presented analysis to minimize false assignments of disease risk.

    • Sanna Gudmundsson
    • Moriel Singer-Berk
    • Anne O’Donnell-Luria
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • Here, the authors profile bacterial engraftment in UC patients receiving FMT from a single donor and placebo samples to estimate noise, showing a significant level of false-positive engraftment, which confounds the prediction of true engraftment, while analyzing engraftment across multiple patients from a single donor enhances the accuracy of detection.

    • Shahrokh Shekarriz
    • Jake C. Szamosi
    • Michael G. Surette
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12

  • Helicobacter pyloriinfection is one likely cause of functional dyspepsia. Here, the authors discuss the clinical evidence in relation toH. pylorieradication in patients with functional dyspepsia if they test positive for this bacterium.

    • Hidekazu Suzuki
    • Paul Moayyedi
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 10, P: 168-174

  • Peter Donnelly and colleagues report a genome-wide association study for Barrett's esophagus, a common premalignant condition associated with stomach acid reflux and predisposing to esophageal adenocarcinoma. They identify two loci associated with susceptibility to Barrett's esophagus.

    • Zhan Su
    • Laura J Gay
    • Janusz A Z Jankowski
    Research
    Nature Genetics
    Volume: 44, P: 1131-1136

  • Exclusion diets are popular in the management of irritable bowel syndrome (IBS). This Review outlines the mechanisms by which food might lead to symptoms in IBS and discusses different approaches to how exclusion diets can be evaluated in randomized controlled trials.

    • Paul Moayyedi
    • Magnus Simrén
    • Premysl Bercik
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 17, P: 406-413

  • Kenneth Croitoru, Andrew Paterson and colleagues perform genome-wide association analysis for gut microbiome composition. They identify 58 SNPs significantly associated with relative abundance of 33 taxa and replicate 4 of the associations in an independent cohort, providing further evidence that host genetics can influence the gut microbiota.

    • Williams Turpin
    • Osvaldo Espin-Garcia
    • Kenneth Croitoru
    Research
    Nature Genetics
    Volume: 48, P: 1413-1417