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Showing 1–5 of 5 results
Advanced filters: Author: Paula Keskula Clear advanced filters

  • Coal and carbon-intensive regions have lagged behind in socioeconomic development, long before any transition-related structural changes were foreseeable. Acknowledging and tackling the compounding effects of old legacy and new transition injustices is vital for realizing a truly just energy transition.

    • Lukas Hermwille
    • Marie Claire Brisbois
    • Annela Anger-Kraavi
    Comments & Opinion
    Nature Energy
    Volume: 10, P: 915-918

  • Identifying therapeutic targets in rare cancers is challenging due to the lack of relevant pre-clinical models. Here, the authors generate a cancer cell line from a paediatric patient with a rare undifferentiated sarcoma and through functional genomics and chemical screens identified CDK4 and XPO1 as potential therapeutic targets in this cancer.

    • Andrew L. Hong
    • Yuen-Yi Tseng
    • Jesse S. Boehm
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-9

  • Systematic metabolite profiling across cancer cell lines uncovers patterns associated with genetic and epigenetic features and reveals dysregulated metabolic states that can be exploited for anticancer therapy

    • Haoxin Li
    • Shaoyang Ning
    • William R. Sellers
    Research
    Nature Medicine
    Volume: 25, P: 850-860

  • Depletion of the DNA helicase WRN induced double-stranded DNA breaks, and promoted apoptosis and cell cycle arrest selectively in cancers with microsatellite instability, indicating that WRN is a promising drug target for the treatment of these cancers.

    • Edmond M. Chan
    • Tsukasa Shibue
    • Adam J. Bass
    Research
    Nature
    Volume: 568, P: 551-556