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The lysosomal degradation of protein aggregates declines with ageing in mammalian neural stem cells, reducing their capacity to transition from a quiescent to an active state.

Congratulations to John Jumper and Demis Hassabis for winning the 2023 Albert Lasker Basic Medical Research Award.

Yu et al. identify senescent cells as important players in the regeneration of complex structures.

The discovery of the CRISPR–Cas9 system by Emmanuelle Charpentier and Jennifer Doudna awarded a 2020 Nobel Prize in Chemistry.

Shelby et al. demonstrate the existence of discrete domains in plasma membranes of B cells that selectively partition membrane-associated proteins.

Rogers et al. provide evidence that hypoxia is beneficial in mammalian ageing, extending the lifespan of prematurely ageing mice.

Weems et al. show that sustained membrane blebbing promotes pro-survival signalling in extracellular matrix-detached cells.

A new study collaboratively delivered by Valentina Greco’s and Smita Krishnaswamy’s labs provides new insight into patterns of calcium signalling in epithelial tissues using intravital imaging of the basal layer of the mouse epidermis.

Cremer et al. show that the ubiquitin ligase RNF26 and vimentin-based intermediate filaments cooperate to control perinuclear ER membrane organization and thus facilitate recovery from ER stress.

Shi et al. show the role of myosin VI in the protection of stalled replication forks during replication stress.

Cheng, Mittnenzweig et al. demonstrate the cellular role of the major DNA demethylation machinery, ten-eleven translocation (TET) dioxygenases, in early mammalian development.

Reyes et al. show that fibroblasts with properties of cellular senescence are present in healthy epithelial tissues and — by upregulating the senescence associated secretory phenotype (SASP) — they support stem-cell function and tissue repair.

Zheng et al. show that calcium transients at the endoplasmic reticulum surface trigger condensation of FIP200 and the formation of ULK1 assemblies for autophagosome biogenesis.

Rensvold et al. provide a resource to characterize the function of mitochondrial proteins and to facilitate the discovery of disease-relevant mutations.

Steinhorst et al. show how calcium signal induced by salt stress is ‘decoded’ by plant roots to provide systemic response and to increase salt tolerance.

Cail et al. introduce a platform to study the role of plasma membrane curvature during clathrin-mediated endocytosis.

Zhang et al. report that angiogenesis in the chick embryo is supported by migrasomes — recently described organelles produced by migrating cells.

Sladitschek-Martens show that reduced activity of key cellular mechanosensors, transcription co-activators YAP/TAZ, is an important driver of ageing of stromal and contractile cells, leading to cell senescence.

Garabedian et al. developed designer biomolecular condensates serving as tools for flexible interrogation and temporal regulation of cell functions.

Betti et al. show that plants can take up microRNAs generated by other plants, and that these exogenous miRNAs are active in silencing the expression of their target genes.

Rana et al. show that in the gut epithelium, gasdermin B has an inherent, non-pyroptotic function, supporting the maintenance of the epithelial barrier when challenged with inflammatory damage.

Torrino et al. show that the stiffness of the extracellular matrix regulates microtubule posttranslational modification via glutamylation, which impacts microtubule dynamics and cell invasiveness.

Kaneshige et al. show that skeletal muscle-resident mesenchymal progenitors relay the mechanical signal of muscle overload to muscle stem cells to induce their proliferation.

Hoijman et al. show that in early vertebrate development, engulfment of apoptotic cells is mediated by epithelial cells covering the embryo, which use specialized protrusions to distribute apoptotic bodies and support their efficient clearance.

The 2021 Nobel Prize in Physiology or Medicine goes to David Julius and Ardem Patapoutian for their work on molecular basis of somatosensation.

Jijumon et al. introduce a straightforward, cell-free assay to unravel the functions of microtubule-associated proteins.

Lengefeld et al. show that haematopoietic stem cell enlargement explains, at least in part, the reduction of tissue regenerative potential with ageing.

Arnold et al. document an alternative tricarboxylic acid cycle that takes place between the mitochondria and the cytosol and that can be adopted in specific cell states.

Xu et al. report engineering a compact version of Cas that can be useful for a broad range of genome engineering applications in mammalian cells.

Ma et al. show the role of CCT2, a chaperonin TRiC subunit, in aggrephagy, specifically in the removal of mature, solid-like protein aggregates.

Mori et al. identify ATP and reactive oxygen species as key upstream cues for cell extrusion.

Gadadhar et al. report that tubulin glycylation enables sustained motion of sperm by regulating the beating of sperm flagella.

Zimmerli and Allegretti et al. show, in fission yeast, that nuclear pores constrict under energy deprivation or osmotic stress, which is linked to a reduction in nuclear membrane tension.

Roney et al. show that neuronal loss in Niemann-Pick disease type C is associated with the impairment of lysosome trafficking by cholesterol that accumulates on lysosome membranes.

Lancaster and colleagues describe a morphological change in early primate brain stem cells, the timing of which could underlie the differences in brain size between human and apes.

Xie et al. show that the hair shaft regulates the size of the hair follicle stem cell niche and consequently its maintenance.

The role of chromosome clustering as a driver of nucleo-cytoplasmic compartmentalization after mitosis.

Direct demonstration that mutations in intrinsically disordered regions modulate protein–protein interaction networks, which may cause disease.

Cells can efficiently invade the tissue in the absence of metalloproteinases by physically breaching the basement membrane.

Glycoproteins of the glycocalyx are shown to have the capacity to bend the plasma membrane.

Demonstration that active collective cell migration importantly contributes to the movement of intestinal epithelial cells along the villi.

The switch from glycolytic metabolism to OXPHOS functions as a driver of cell immortalization during tumorigenesis in the fly brain.

Bass and colleagues uncover a role for NAD⁺ in preventing age-related decline in circadian function in mice.

A new study in Science shows that AMPK is an inhibitor of caspase 6-driven hepatic cell death in non-alcoholic steatohepatitis.

Vietri et al. show that failure to repair micronuclear membranes is caused by unrestrained activity of ESCRT-III.

Increased shortening of RNA 3′ untranslated regions associated with tumorigenic transformation interferes with competing endogenous RNA (ceRNA) networks, which results in trans-repression of tumour suppressors through microRNA-mediated silencing.

Hydraulic forces have important roles in the early development of mouse embryos.

A new study demonstrates that glypicans shield the palmitoleate on WNTs to enable their distribution in tissues.