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Showing 1–11 of 11 results

Advanced filters: Author: Pavan K. Auluck Clear advanced filters

Downregulated transcription in chromosomal domains of midbrain dopamine neurons linked to schizophrenia

Midbrain dopamine neurons play a key role in schizophrenia and bipolar disorder. The authors report that altered dopaminergic gene expression in schizophrenia preferentially affects sites with complex chromosomal organization linked to genetic risk.

Swadha Singh
Marina Iskhakova
Schahram Akbarian
ResearchOpen Access06 Apr 2026
Nature Communications

P: 1-14
The neuronal chromatin landscape in brains from individuals with schizophrenia is linked to early fetal development

This study maps chromatin accessibility in neurons and glia in schizophrenia, revealing fetal-like regulatory patterns in adult neurons enriched for genetic risk variants, linking early brain development to schizophrenia pathogenesis

Kiran Girdhar
Jaroslav Bendl
Panos Roussos
Research27 Oct 2025
Nature Neuroscience

Volume: 28, P: 2451-2460
A transcriptomic dimension of neuronal and immune gene programs within the subgenual anterior cingulate cortex in schizophrenia

Rachel L. Smith
Agoston Mihalik
Francis J. McMahon
ResearchOpen Access19 Feb 2026
Translational Psychiatry

Volume: 16, P: 1-12
Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity

Ernest Fraenkel and colleagues present ResponseNet, a method used to integrate analysis of genetic and transcriptional datasets, and its application characterizing yeast cellular responses to alpha-synuclein toxicity.

Esti Yeger-Lotem
Laura Riva
Ernest Fraenkel
Research22 Feb 2009
Nature Genetics

Volume: 41, P: 316-323
Pharmacological prevention of Parkinson disease in Drosophila

Pavan K. Auluck
Nancy M. Bonini
Correspondence01 Nov 2002
Nature Medicine

Volume: 8, P: 1185-1186
Population-level variation in enhancer expression identifies disease mechanisms in the human brain

Analyses of population-level variation in gene and enhancer expression in the human brain characterize the gene–enhancer regulome and the regulatory mechanisms of transcribed enhancers in neuropsychiatric diseases.

Pengfei Dong
Gabriel E. Hoffman
Panos Roussos
Research26 Sept 2022
Nature Genetics

Volume: 54, P: 1493-1503
Cortico-striatal differences in the epigenome in attention-deficit/ hyperactivity disorder

Gauri G. Shastri
Gustavo Sudre
Philip Shaw
ResearchOpen Access11 Apr 2024
Translational Psychiatry

Volume: 14, P: 1-8
Antipsychotic drug use complicates assessment of gene expression changes associated with schizophrenia

Anton Schulmann
Stefano Marenco
Francis J. McMahon
ResearchOpen Access17 Mar 2023
Translational Psychiatry

Volume: 13, P: 1-8
Mapping the cortico-striatal transcriptome in attention deficit hyperactivity disorder

Gustavo Sudre
Derek E. Gildea
Philip Shaw
Research16 Nov 2022
Molecular Psychiatry

Volume: 28, P: 792-800
Deep transcriptome sequencing of subgenual anterior cingulate cortex reveals cross-diagnostic and diagnosis-specific RNA expression changes in major psychiatric disorders

Nirmala Akula
Stefano Marenco
Francis J. McMahon
ResearchOpen Access08 Feb 2021
Neuropsychopharmacology

Volume: 46, P: 1364-1372
Population-scale cross-disorder atlas of the human prefrontal cortex at single-cell resolution

John F. Fullard
Prashant NM
Panos Roussos
ResearchOpen Access06 Jun 2025
Scientific Data

Volume: 12, P: 1-13