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Showing 1–5 of 5 results

Advanced filters: Author: Pawel F. Przytycki Clear advanced filters

A multimodal approach for visualizing and identifying electrophysiological cell types in vivo

In this study, the authors develop PhysMAP, which combines multiple electrophysiological features to identify neuronal cell types in the neural circuit, advancing the ability to investigate circuit dynamics without genetic or optical access during behavior.

Eric Kenji Lee
Asım E. Gül
Chandramouli Chandrasekaran
ResearchOpen Access15 Apr 2026
Nature Communications

P: 1-21
Chromatin remodelling drives immune cell–fibroblast communication in heart failure

Conditional deletion of the transcriptional co-activator Brd4 in infiltrating Cx3cr1⁺ mouse macrophages ameliorates heart failure and substantially reduces fibroblast activation.

Michael Alexanian
Arun Padmanabhan
Deepak Srivastava
Research23 Oct 2024
Nature

Volume: 635, P: 434-443
Uncovering the genetic circuits that drive diseases

A hierarchical Bayesian method identifies cell-type specific changes in gene regulatory circuits in disease by integrating single-cell and three-dimensional measurements of the genome.

Pawel F. Przytycki
News & Views25 Jul 2023
Nature Computational Science

Volume: 3, P: 584-585
A transcriptional switch governs fibroblast activation in heart disease

BET proteins regulate a reversible transcriptional switch that governs fibroblast activation in heart disease through the transcription factor MEOX1.

Michael Alexanian
Pawel F. Przytycki
Deepak Srivastava
Research23 Jun 2021
Nature

Volume: 595, P: 438-443
Single-cell epigenomics reveals mechanisms of human cortical development

Analysis of chromatin state at a single-cell level in samples of developing human forebrain demonstrate both cell-type-specific and region-specific changes during neurogenesis.

Ryan S. Ziffra
Chang N. Kim
Tomasz J. Nowakowski
ResearchOpen Access06 Oct 2021
Nature

Volume: 598, P: 205-213