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Showing 1–5 of 5 results
Advanced filters: Author: Pedro Latorre-Muro Clear advanced filters
  • How adipose mitochondria activity is fine-tuned in response to obesity is an active area of study. Here, the authors show that mitochondrial protein MCJ can block thermogenesis and that silencing this gene can correct obesity-related comorbidities.

    • Beatriz Cicuéndez
    • Alfonso Mora
    • Guadalupe Sabio
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16
  • A chemical screen identifies DHODH inhibitors as robust activators of mitochondrial respirasome assembly. Lipidomics reveal that peroxisomal-derived ether phospholipids accumulate in mitochondria during nucleotide deprivation to drive proliferation.

    • Christopher F. Bennett
    • Katherine E. O’Malley
    • Pere Puigserver
    Research
    Nature Chemical Biology
    Volume: 17, P: 703-710
  • Mitochondrial respiratory function needs to adapt to the energetic demands of the cell. These adaptive responses encompass transcriptional, translational and post-translational mechanisms that together enable regulation of respiratory chain assembly and mitochondrial membrane remodelling to fine-tune energy generation in accordance with intracellular and extracellular cues.

    • Christopher F. Bennett
    • Pedro Latorre-Muro
    • Pere Puigserver
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 23, P: 817-835
  • In an unbiased screen, Perry et al. find that tetracycline antibiotics improve resilience of cultured cells carrying disease-associated mitochondrial DNA mutations. Doxycycline is shown to increases survival, and reduce symptoms, in a mouse model of Leigh syndrome.

    • Elizabeth A. Perry
    • Christopher F. Bennett
    • Pere Puigserver
    Research
    Nature Metabolism
    Volume: 3, P: 33-42