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Acta Pharmacologica Sinica (16)
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Showing 1–50 of 54 results

Advanced filters: Author: Pei-Pei Wang Clear advanced filters

Single-cell mapping of peripheral immune dynamics in pregnant women after Moderna mRNA COVID-19 vaccination

Yu-Ting Kang
Tsai-Jung Lu
Tzu-Hung Hsiao
ResearchOpen Access14 Apr 2026
Genes & Immunity

P: 1-10
Customized cycloparaphenylene skeletons prepared via the intramolecular coupling of extended biphen[n]arenes

Intramolecular coupling of extended biphen[n]arenes is developed to yield cycloparaphenylenes (CPPs). The modular nature of biphen[n]arenes makes it possible to customize CPP structures, which permits tuning of their photophysical properties. The syntheses are short and excellent yields are achieved. Moreover, postsynthetic functionalization is possible.

Xu-Sheng Du
Pei-Pei Meng
Chunju Li
Research06 Jan 2026
Nature Synthesis

Volume: 5, P: 608-617
Metasurface-integrated vertical cavity surface-emitting lasers for programmable directional lasing emissions

Non-intrusive integration of metasurfaces with vertical cavity surface-emitting lasers enables fully arbitrary wavefront control for directional laser emission.

Yi-Yang Xie
Pei-Nan Ni
Patrice Genevet
Research13 Jan 2020
Nature Nanotechnology

Volume: 15, P: 125-130
Substrate-dependent modulation of the catalytic activity of CYP3A by erlotinib

Pei-pei Dong
Zhong-ze Fang
Ling Yang
Research04 Mar 2011
Acta Pharmacologica Sinica

Volume: 32, P: 399-407
Rapid discovery of self-assembling peptides with one-bead one-compound peptide library

Self-assembling peptides have a range of potential applications but developing self-assembling sequences can be challenging. Here, the authors report on a one-bead one-compound combinatorial library where fluorescence is used to detect the potential for self-assembly and identified candidates are evaluated.

Pei-Pei Yang
Yi-Jing Li
Kit S. Lam
ResearchOpen Access23 Jul 2021
Nature Communications

Volume: 12, P: 1-8
De novo design of hypercompact transcript degraders by engineering substrate-specific toxins and Cas6-CBS system

Artificial assembly of small functional proteins provides effective strategies for downsizing RNA degraders. Here, authors develop STAR, a hypercompact RNA degrader with evolved toxin endoribonucleases and engineered Cas6- CBS system, enabling efficient degradation of cytoplasmic and nuclear RNAs.

Pin-Ru Chen
Pei-Pei Qin
Bin-Cheng Yin
ResearchOpen Access26 Sept 2025
Nature Communications

Volume: 16, P: 1-14
Aliskiren ameliorates pressure overload-induced heart hypertrophy and fibrosis in mice

Li-qing Weng
Wen-bin Zhang
Yun-zeng Zou
Research07 Jul 2014
Acta Pharmacologica Sinica

Volume: 35, P: 1005-1014
Region-resolved proteomic map of the human brain: functional interconnections and neurological implications

Pei-Pei Zhang
Man-Sheng Li
Ling Leng
ResearchOpen Access04 Feb 2026
Signal Transduction and Targeted Therapy

Volume: 11, P: 1-19
Long-term increased grain yield and soil fertility from intercropping

Growing demand for food is confronting constraints to its sustainable production. This study finds that intercropping increases grain yields and their stability and that yield benefits increase over time.

Xiao-Fei Li
Zhi-Gang Wang
Long Li
Research04 Oct 2021
Nature Sustainability

Volume: 4, P: 943-950
A self-destructive nanosweeper that captures and clears amyloid β-peptides

Cerebral amyloid β-peptide accumulation is a causative factor in Alzheimer’s Disease. Here the authors design a 'nanosweeper' that binds amyloid β-peptide and induces autophagy to clear the accumulated plagues.

Qiang Luo
Yao-Xin Lin
Hao Wang
ResearchOpen Access04 May 2018
Nature Communications

Volume: 9, P: 1-12
Maternal regulation of biliary disease in neonates via gut microbial metabolites

The pathogenesis of biliary atresia remains poorly understood. Here, the authors report that maternal butyrate treatment alters the gut microbiome and glutamine/hypoxanthine metabolites similar to human subjects, and suppresses biliary atresia in newborn mice.

Jai Junbae Jee
Li Yang
Jorge A. Bezerra
ResearchOpen Access10 Jan 2022
Nature Communications

Volume: 13, P: 1-15
The piRNA CHAPIR regulates cardiac hypertrophy by controlling METTL3-dependent N⁶-methyladenosine methylation of Parp10 mRNA

Gao et al. identify a piRNA, CHAPIR, that targets the m⁶A methylation of PARP10 and promotes the GSK3β-induced accumulation of nuclear NFATC4, thereby modulating cardiac hypertrophy and heart function upon pressure overload.

Xiang-Qian Gao
Yu-Hui Zhang
Kun Wang
Research05 Oct 2020
Nature Cell Biology

Volume: 22, P: 1319-1331
Inflammation-activated CXCL16 pathway contributes to tubulointerstitial injury in mouse diabetic nephropathy

Ze-bo Hu
Kun-ling Ma
Bi-cheng Liu
Research05 Apr 2018
Acta Pharmacologica Sinica

Volume: 39, P: 1022-1033
HK1 from hepatic stellate cell–derived extracellular vesicles promotes progression of hepatocellular carcinoma

Hexokinase 1 is found to be secreted from hepatic stellate cells in large extracellular vesicles in response to TGF-β, and is subsequently taken up by hepatocellular carcinoma cells, where it promotes tumor progression and metastasis.

Qi-tao Chen
Zhi-yuan Zhang
Qiao Wu
ResearchOpen Access03 Oct 2022
Nature Metabolism

Volume: 4, P: 1306-1321
Clinical and biomarker analyses of sintilimab plus gemcitabine and cisplatin as first-line treatment for patients with advanced biliary tract cancer

Chemotherapeutic agents and immune checkpoint inhibitors have shown modest efficacy in patients with advanced biliary tract cancers (BTCs). Here the authors report the results of a phase II trial of the anti-PD1 antibody sintilimab plus chemotherapy (gemcitabine and cisplatin) as first-line treatment for patients with advanced BTCs.

Tian-mei Zeng
Guang Yang
Zhen-gang Yuan
ResearchOpen Access11 Mar 2023
Nature Communications

Volume: 14, P: 1-14
Microglial EED is required for synapse engulfment

Ying-Ying Wang
Yu-Sen Deng
Zhao-Qian Teng
Research17 Jun 2022
Molecular Psychiatry

Volume: 27, P: 2915
GEAR: A database of Genomic Elements Associated with drug Resistance

Yin-Ying Wang
Wei-Hua Chen
Xing-Ming Zhao
ResearchOpen Access15 Mar 2017
Scientific Reports

Volume: 7, P: 1-8
Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance

Polycomb repressive complex 2 (PRC2) mediates gene silencing through chromatin reorganization by methylation of histone H3 lysine 27 (H3K27). Here, the authors present crystal structures of the inhibitor-bound wild-type and a mutant form of PRC2.

Alexei Brooun
Ketan S. Gajiwala
Al E. Stewart
ResearchOpen Access28 Apr 2016
Nature Communications

Volume: 7, P: 1-12
Calcium mediates high glucose-induced HIF-1α and VEGF expression in cultured rat retinal Müller cells through CaMKII-CREB pathway

Jun Li
Shu-zhi Zhao
Xun Xu
Research16 Jul 2012
Acta Pharmacologica Sinica

Volume: 33, P: 1030-1036
Modeling resistance index of taxoids to MCF-7 cell lines using ANN together with electrotopological state descriptors

Pei-pei Dong
Yan-yan Zhang
Chang-xiao Liu
Research01 Mar 2008
Acta Pharmacologica Sinica

Volume: 29, P: 385-396
Resveratrol significantly improves the fertilisation capacity of bovine sex-sorted semen by inhibiting apoptosis and lipid peroxidation

Chong-Yang Li
Ya-Han Zhao
Xue-Ming Zhao
ResearchOpen Access15 May 2018
Scientific Reports

Volume: 8, P: 1-10
Retraction Note: The role of cyclooxygenase-2, interleukin-1β and fibroblast growth factor-2 in the activation of matrix metalloproteinase-1 in sheared-chondrocytes and articular cartilage

Pei-Pei Guan
Jing-Wen Guo
Pu Wang
Amendments and CorrectionsOpen Access08 Apr 2025
Scientific Reports

Volume: 15, P: 1
Ambient light alleviates retinal neurodegeneration in mice by powering mitochondria via the engineered optoenergetic rhodopsin

Run-Zhou Yang
Yiting Wang
Jian-Sheng Kang
ResearchOpen Access30 Oct 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-25
TFP5 peptide, derived from CDK5-activating cofactor p35, provides neuroprotection in early-stage of adult ischemic stroke

Ya-Bin Ji
Pei-Pei Zhuang
Ya-Fang Hu
ResearchOpen Access03 Jan 2017
Scientific Reports

Volume: 7, P: 1-7
Abnormal chromatin remodeling caused by ARID1A deletion leads to malformation of the dentate gyrus

Pei-Pei Liu
Shi-Ping Lu
Chang-Mei Liu
Research05 Aug 2023
Cell Death & Differentiation

Volume: 30, P: 2187-2199
Diversity and evolution of the MHC class II DRB gene in the Capra sibirica experienced a demographic fluctuation in China

Pei-Pei Dong
Rui-Rui Wang
Shamshidin Abduriyim
ResearchOpen Access07 Nov 2023
Scientific Reports

Volume: 13, P: 1-11
Addendum: Prostaglandin I₂ Attenuates Prostaglandin E₂-Stimulated Expression of Interferon γ in a β-Amyloid Protein- and NF-κB-Dependent Mechanism

Pu Wang
Pei-Pei Guan
Zhan-You Wang
Amendments and CorrectionsOpen Access19 May 2022
Scientific Reports

Volume: 12, P: 1-3
A cohort autopsy study defines COVID-19 systemic pathogenesis

Xiao-Hong Yao
Tao Luo
Xiu-Wu Bian
ResearchOpen Access16 Jun 2021
Cell Research

Volume: 31, P: 836-846
Clinical efficacy and immune response of neoadjuvant camrelizumab plus chemotherapy in resectable locally advanced oesophageal squamous cell carcinoma: a phase 2 trial

Yue-Yun Chen
Pei-Pei Wang
Zhen-Yu Ding
ResearchOpen Access20 Aug 2024
British Journal of Cancer

Volume: 131, P: 1126-1136
Prostaglandin I₂ Attenuates Prostaglandin E₂-Stimulated Expression of Interferon γ in a β-Amyloid Protein- and NF-κB-Dependent Mechanism

Pu Wang
Pei-Pei Guan
Zhan-You Wang
ResearchOpen Access12 Feb 2016
Scientific Reports

Volume: 6, P: 1-16
Discovery of a selective TRF2 inhibitor FKB04 induced telomere shortening and senescence in liver cancer cells

Yin-da Qiu
Qi Yan
Zhi-guo Liu
Research04 Mar 2024
Acta Pharmacologica Sinica

Volume: 45, P: 1276-1286
Analysis of the characteristics of intestinal microbiota in patients with different severity of obstructive sleep apnea

Pei-Pei Wang
Li-Juan Wang
Bei Wang
ResearchOpen Access16 Sept 2024
Scientific Reports

Volume: 14, P: 1-13
A new cytotoxic indole-3-ethenamide from the halotolerant fungus Aspergillus sclerotiorum PT06-1

Hui Wang
Jin-Kai Zheng
Wei-Ming Zhu
Research27 Jul 2011
The Journal of Antibiotics

Volume: 64, P: 679-681
Therapeutic targeting miR130b counteracts diffuse large B-cell lymphoma progression via OX40/OX40L-mediated interaction with Th17 cells

Rui Sun
Pei-Pei Zhang
Wei-Li Zhao
ResearchOpen Access18 Mar 2022
Signal Transduction and Targeted Therapy

Volume: 7, P: 1-14
Fecal microbiota transplantation improves metabolism and gut microbiome composition in db/db mice

Pei-pei Zhang
Lin-lin Li
Ye Wang
Research14 Jan 2020
Acta Pharmacologica Sinica

Volume: 41, P: 678-685
Stepwise extraction of zinc, indium and lead from secondary zinc oxide dusts experimental study

Gui-hua WANG
Pei-pei DU
Jian-song ZHANG
ResearchOpen Access03 Dec 2024
Scientific Reports

Volume: 14, P: 1-17
Author Correction: Discovery of a selective TRF2 inhibitor FKB04 induced telomere shortening and senescence in liver cancer cells

Yin-da Qiu
Qi Yan
Zhi-guo Liu
Amendments and Corrections28 Aug 2024
Acta Pharmacologica Sinica

Volume: 46, P: 512-514
Genome-wide identification of microRNA targets reveals positive regulation of the Hippo pathway by miR-122 during liver development

Yin Zhang
Ye-Ya Tan
Liang-Hu Qu
ResearchOpen Access14 Dec 2021
Cell Death & Disease

Volume: 12, P: 1-12
RETRACTED ARTICLE: The Role of Cyclooxygenase-2, Interleukin-1β and Fibroblast Growth Factor-2 in the Activation of Matrix Metalloproteinase-1 in Sheared-Chondrocytes and Articular Cartilage

Pei-Pei Guan
Jing-Wen Guo
Pu Wang
ResearchOpen Access20 May 2015
Scientific Reports

Volume: 5, P: 1-14
Genomic analysis reveals genes affecting distinct phenotypes among different Chinese and western pig breeds

Zhe Zhang
Qian Xiao
Yu-chun Pan
ResearchOpen Access06 Sept 2018
Scientific Reports

Volume: 8, P: 1-12
The roles of prostaglandin F₂ in regulating the expression of matrix metalloproteinase-12 via an insulin growth factor-2-dependent mechanism in sheared chondrocytes

Pei-Pei Guan
Wei-Yan Ding
Pu Wang
ResearchOpen Access23 Nov 2018
Signal Transduction and Targeted Therapy

Volume: 3, P: 1-13
DL-3-n-butylphthalide ameliorates diabetes-associated cognitive decline by enhancing PI3K/Akt signaling and suppressing oxidative stress

Bei-ni Wang
Cheng-biao Wu
Jian Wang
Research18 Jan 2021
Acta Pharmacologica Sinica

Volume: 42, P: 347-360
Luteolin-7-diglucuronide, a novel PTP1B inhibitor, ameliorates hepatic stellate cell activation and liver fibrosis in mice

Bi-xi Tang
Yong Zhang
Yi Zang
Research05 Aug 2024
Acta Pharmacologica Sinica

Volume: 46, P: 122-133
Adapting the endoplasmic reticulum proteostasis rescues epilepsy-associated NMDA receptor variants

Pei-pei Zhang
Taylor M. Benske
Ya-juan Wang
Research06 Oct 2023
Acta Pharmacologica Sinica

Volume: 45, P: 282-297
Ripretinib inhibits HIV-1 transcription through modulation of PI3K-AKT-mTOR

Jin-feng Cai
Jia-sheng Zhou
Kai Deng
Research16 Apr 2024
Acta Pharmacologica Sinica

Volume: 45, P: 1632-1643
Acetyl-CoA synthetase 2 promotes diabetic renal tubular injury in mice by rewiring fatty acid metabolism through SIRT1/ChREBP pathway

Jian Lu
Xue-qi Li
Kun-ling Ma
Research28 Sept 2023
Acta Pharmacologica Sinica

Volume: 45, P: 366-377
Loss of microglial EED impairs synapse density, learning, and memory

Ying-Ying Wang
Yu-Sen Deng
Zhao-Qian Teng
Research28 Apr 2022
Molecular Psychiatry

Volume: 27, P: 2999-3009
Publisher Correction: Inflammation-activated CXCL16 pathway contributes to tubulointerstitial injury in mouse diabetic nephropathy

Ze-bo Hu
Kun-ling Ma
Bi-cheng Liu
Amendments and Corrections23 Apr 2019
Acta Pharmacologica Sinica

Volume: 40, P: 989-990
Platelet microparticles contribute to aortic vascular endothelial injury in diabetes via the mTORC1 pathway

Gui-hua Wang
Kun-ling Ma
Bi-cheng Liu
Research16 Nov 2018
Acta Pharmacologica Sinica

Volume: 40, P: 468-476
Gut microbiota dysbiosis-induced activation of the intrarenal renin–angiotensin system is involved in kidney injuries in rat diabetic nephropathy

Chen-chen Lu
Ze-bo Hu
Kun-ling Ma
Research17 Mar 2020
Acta Pharmacologica Sinica

Volume: 41, P: 1111-1118

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