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De novo design of light-responsive protein–protein interactions enables reversible formation of protein assemblies

Light-responsive proteins hold significant potential in biotechnology but naturally occurring examples are scarce and limited in diversity. Now a totally de novo computational approach has been developed to design light-responsive proteins with diverse architectures by precisely incorporating the non-canonical amino acid phenylalanine-4′-azobenzene (AzoF), which is responsive to light.

Bowen Yu
Jiao Liu
Longxing Cao
Research28 Aug 2025
Nature Chemistry

Volume: 17, P: 1910-1919
Vitellogenin receptor mediates heat adaptability of oocyte development in mud crabs and zebrafish

Climate-driven warming affects the reproduction of oviparous ectotherms. Here, authors identify and characterize a VtgR-mediated heat protection mechanism for oocyte development in both mud crabs and zebrafish.

Long Zhang
Kun Wu
Muhua Wang
ResearchOpen Access19 Apr 2025
Nature Communications

Volume: 16, P: 1-17
Ultra-low-loss on-chip zero-index materials

Tian Dong
Jiujiu Liang
Yang Li
ResearchOpen Access07 Jan 2021
Light: Science & Applications

Volume: 10, P: 1-9
Value of radiomics model based on enhanced computed tomography in risk grade prediction of gastrointestinal stromal tumors

Hairui Chu
Peipei Pang
Rongchun Xu
ResearchOpen Access08 Jun 2021
Scientific Reports

Volume: 11, P: 1-7
Busulfan and cyclosphamide induce liver inflammation through NLRP3 activation in mice after hematopoietic stem cell transplantation

Jianlin Qiao
Yujin Huang
Lingyu Zeng
ResearchOpen Access04 Dec 2015
Scientific Reports

Volume: 5, P: 1-10
Structural dynamics of Populus euphratica forests in different stages in the upper reaches of the Tarim River in China

Ning Miao
Peipei Jiao
Timothy C. Moermond
ResearchOpen Access21 Feb 2020
Scientific Reports

Volume: 10, P: 1-12
Non-canonical telomere protection role of FOXO3a of human skeletal muscle cells regulated by the TRF2-redox axis

Loss of the telomeric repeat binding factor 2 (TRF2) and its resulting oxidative stress leads to FOXO3a binding to telomeres, which protects against activation of ATM to maintain skeletal muscle homeostasis.

Maria Sol Jacome Burbano
Jérôme D. Robin
Eric Gilson
ResearchOpen Access25 May 2023
Communications Biology

Volume: 6, P: 1-11
Undrained shear behavior of silty sand with a constant state parameter considering initial stress anisotropy effect

Peipei Li
Chen Zhu
Kun Pan
ResearchOpen Access26 Jan 2024
Scientific Reports

Volume: 14, P: 1-14
MiRNA-363-3p/DUSP10/JNK axis mediates chemoresistance by enhancing DNA damage repair in diffuse large B-cell lymphoma

Wenping Zhou
Yuanlin Xu
Yanyan Liu
ResearchOpen Access29 Apr 2022
Leukemia

Volume: 36, P: 1861-1869
A single-cell transcriptomic landscape of the lungs of patients with COVID-19

Wang et al. analysed post-mortem samples of the lungs of patients with COVID-19 by bulk and single-nucleus RNA sequencing along with proteomics and discovered lung senescence as a feature of COVID-19 pathology.

Si Wang
Xiaohong Yao
Xiu-Wu Bian
Research07 Dec 2021
Nature Cell Biology

Volume: 23, P: 1314-1328
Itaconate protects ferroptotic neurons by alkylating GPx4 post stroke

Chao Wei
Zhongnan Xiao
Qian Li
Research08 May 2024
Cell Death & Differentiation

Volume: 31, P: 983-998
CD59 is a potential biomarker of esophageal squamous cell carcinoma radioresistance by affecting DNA repair

Yuzhen Zhou
Li Chu
Weiguo Hu
ResearchOpen Access30 Aug 2018
Cell Death & Disease

Volume: 9, P: 1-13
Targeting the COX2/MET/TOPK signaling axis induces apoptosis in gefitinib-resistant NSCLC cells

Juanjuan Xiao
Fei Wang
Feng Zhu
ResearchOpen Access14 Oct 2019
Cell Death & Disease

Volume: 10, P: 1-12

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De novo design of light-responsive protein–protein interactions enables reversible formation of protein assemblies

Vitellogenin receptor mediates heat adaptability of oocyte development in mud crabs and zebrafish

Ultra-low-loss on-chip zero-index materials

Value of radiomics model based on enhanced computed tomography in risk grade prediction of gastrointestinal stromal tumors

Busulfan and cyclosphamide induce liver inflammation through NLRP3 activation in mice after hematopoietic stem cell transplantation

Structural dynamics of Populus euphratica forests in different stages in the upper reaches of the Tarim River in China

Non-canonical telomere protection role of FOXO3a of human skeletal muscle cells regulated by the TRF2-redox axis

Undrained shear behavior of silty sand with a constant state parameter considering initial stress anisotropy effect

MiRNA-363-3p/DUSP10/JNK axis mediates chemoresistance by enhancing DNA damage repair in diffuse large B-cell lymphoma

A single-cell transcriptomic landscape of the lungs of patients with COVID-19

Itaconate protects ferroptotic neurons by alkylating GPx4 post stroke

CD59 is a potential biomarker of esophageal squamous cell carcinoma radioresistance by affecting DNA repair

Targeting the COX2/MET/TOPK signaling axis induces apoptosis in gefitinib-resistant NSCLC cells

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