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How inflammation spreads from the skin to the joints in psoriatic disease is unclear. Here, the authors show that joint-resident fibroblasts can control differentiation of infiltrating skin-derived myeloid precursors that can become inflammatory macrophages.

Quantifying ecosystem dynamics is critical in the face of rapid environmental change. This study uses airborne eDNA to quantify changes in organism abundances across the tree of life and reveal a regional decline in biodiversity over three decades.

The genomes of 28 ancient southern African individuals dated to between 10,200 and 150 years before present offer insights into the evolution of Homo sapiens.

Genomic analyses applied to 14 childhood- and adult-onset psychiatric disorders identifies five underlying genomic factors that explain the majority of the genetic variance of the individual disorders.

Robbie Waugh and colleagues report that the EARLINESS PER SE (EPS2) locus is associated with spring growth habit and environmental adaptation in barley. Resequencing the barley homolog of CENTRORADIALIS, located within the EPS2 locus, in 216 spring and 207 winter barley accessions identified haplotypes at HvCEN that correspond with winter or spring growth habit.

The interplay between neuronal activity and tumor progression is well-established. Here, the authors demonstrate that blockade of β-adrenergic signaling via administration of propranolol suppresses lung metastasis in multiple mouse tumor models by enhancing the accumulation of cytotoxic CD4 T cells while reducing CCR2+ monocytes, highlighting the re-purposing of β-blockers as a valid therapeutic approach for cancer treatment.

Using population and ecological genomic approaches, the authors demonstrate the potential for interspecific introgression—the transfer of genetic material following hybridization—to reduce climate change vulnerability. Their findings emphasize the importance of preserving interspecific connectivity.

Sequence control of multiblock copolymers is a difficult task for polymer chemistry. Here the authors report a simple radical method that allows the synthesis of well-defined block copolymers with a wide range of functional groups, including a 20-unit multiblock copolymer.

Chemists increasingly seek to control monomer sequencing in aperiodic copolymers. Here, the authors show that the statistical nature of chain growth strongly limits the achievable control, and establish parameters for polymer design that balance precise control with simplicity of synthesis.

Engineering mammalian cells with synthetic circuits drives innovation in next-generation biotherapeutics and industrial biotechnology. Here the authors use RNA-seq and computational biology to identify drugs that increase engineered cell productivity without genetic edits - Filgotinib proved enhanced gene expression across contexts, offering a powerful tool for biotech applications.

HistoPlexer, a deep learning model, generates multiplexed protein expression maps from H&E images, capturing tumour–immune cell interactions. It outperforms baselines, enhances immune subtyping and survival prediction and offers a cost-effective tool for precision oncology.

Patients who express a hyperactive mutant of the kinase PI3K exhibit defective humoral immunity. Preite et al. show that overactive PI3K leads to defective class-switched antigen-specific responses to immunization, despite augmented germinal-center formation and reactivity to commensal microbes and self antigens.

Genome-wide association analyses identify new risk loci for heart failure and its subtypes, extending understanding of the underlying biological pathways and disease mechanisms.

In a randomized trial testing two types of catheter ablation treatments for persistent atrial fibrillation, a large-tip, dual pulsed field and radiofrequency catheter with a large footprint was non-inferior to a conventional radiofrequency catheter.

Nature synthesizes proteins and nucleic acids by polymerization methods that use well-regulated and segregated templates. Now, synthetic block-copolymer templates have been designed to assemble in a biomimetic fashion to segregate, and thus control, the synthetic radical polymerization of complementary nucleobase-containing vinyl monomers, to yield high-molecular-weight, low-polydispersity polymer chains.

A large, lobe-finned fish from the Late Devonian of China disrupts previously accepted stem-tetrapod phylogeny and reveals parallel evolution within the lineage.

Psoriasis is a partially heritable skin disorder, the genetic basis of which is not fully understood. Here, the authors use genome-wide association meta-analysis to discover psoriasis susceptibility loci and genes, which encode existing and potential new drug targets.

The claustrum/dorsal endopiriform cortex (CLA) is a complex brain region with an unclear function. Here, the authors show that Nurr1 is important for maintaining neuron identity and receptor expression linked to hallucinatory states in this region.

Helleday and colleagues describe a nanomolar MTHFD2 inhibitor that causes replication stress and DNA damage accumulation in cancer cells via thymidine depletion, demonstrating a potential therapeutic strategy in AML tumors in vivo.

The sheer number of parameters in deep learning makes the physical interpretation of failure predictions in glasses challenging. Here the authors use Grad-CAM to reveal the role of topological defects and local potential energies in failure predictions.

Computationally designed genetically encoded proteins can be used to target surface proteins, thereby triggering endocytosis and subsequent intracellular degradation, activating signalling or increasing cellular uptake in specific tissues.

Using multi-ancestry genome-wide association study and fine-mapping, 298 loci and 36 credible genes are identified in the aetiology of bipolar disorder.

N-oxidation of N-heterocycles is essential in the synthesis of natural products and intermediates for pharmaceuticals and pesticides but challenging due to low efficacy and poor regioselectivity. Here, the authors employ structure-guided directed evolution of Bacillus megaterium P450BM3 to obtain variants with expanded N-oxidation selectivity for the synthesis of N-heterocyclic N-oxides.

This study establishes a key role for the developmental transcription factors Lmx1a/b in the maintenance of midbrain dopamine neurons. The authors show that postmitotic ablation of Lmx1b in mice leads to cellular and functional abnormalities resembling Parkinson's disease, most notably in a dysfunction in the autophagic-lysosomal pathway that results in abnormal dopaminergic synaptic connections and neuronal degeneration.

The molecular mechanisms underlying drug resistance in relapsed or refractory (rr) acute myeloid leukemia (AML) remain to be explored. Here, the use of bulk and single cell multi-omics and ex vivo drug profiling for 21 rrAML patients reveals mechanisms of resistance to the Bcl-2 inhibitor venetoclax and treatment vulnerabilities.

Liver X receptor drives epithelial Areg-mediated intestinal regeneration, while preventing tumour growth through adaptive immune responses.

Fully connected neural networks in the infinite-width limit often outperform finite-width models, while convolutional networks excel at finite widths. Here, the authors uncover how convolutional networks leverage local, data-dependent kernel renormalization, enabling feature learning to absent in fully connected architectures.

Serino et al. studied the sense of agency for actions generated via a brain–machine interface. They show that primary motor cortex encodes not only motor and sensory signals, but also subjective agency signals, enabling improved brain–machine interface proficiency.

Genome-wide association analyses of 41,917 bipolar disorder cases and 371,549 controls of European ancestry provide new insights into the etiology of this disorder and identify novel therapeutic leads and potential opportunities for drug repurposing.

Marine life depends on zooplankton like krill, but it’s uncertain how these species will respond to a warming ocean. This study of genome variation in the Northern krill uncovered many gene variants that could be crucial for environmental adaptation and support stock assessment under climate change.

NNC2215 is an insulin conjugate that can reversibly adjust its bioactivity in response to a diabetes-relevant glucose range in vivo.

A 10 Gb s^–1 phase modulator based on a graphene-on-silicon Mach–Zehnder interferometer (MZI) is reported. The compact device has a phase-shifter length of only 300 μm and provides modulation of light at 1,550 nm with a 35 dB extinction ratio.

DeepTaskGen uses deep learning to generate synthetic task-based fMRI maps from resting state data, enabling scalable neuroimaging studies. It preserves individual variation and outperforms benchmarks in biomarker and cognitive prediction.

Previous work has identified several genes where mutations lead to breast cancer, but other genetic and environmental factors must still be accounted for. A large study of genetic association with breast cancer points to four novel genes and many more genetic markers that should be pursued for their link to cancer susceptibility.

Analysis of a fossil trackway from the earliest Carboniferous of Australia shows prints of toes with claws, suggesting that the origin of amniotes was at least 35–40 million years earlier than previously thought.

Here the authors present a genome-wide study linking 20 genetic markers to coronary plaque burden, revealing differences in coronary and carotid atherosclerosis genetics. It also demonstrates and quantifies a causal link between coronary plaques and myocardial infarction.

Here, the authors compare 76 dental calculus oral microbiomes from Palaeolithic hunter-gatherers with Neolithic and Copper Age farmers living in the same region of Italy. Integrating these data with archaeological data and dietary information, they find evidence of a gradual transition to agriculture.

Examination of immunological changes in transgender individuals undergoing gender-affirming testosterone treatment reveals sex hormone-regulated pathways in humans and explains sex-divergent responses in cisgender individuals.

The overexpression of the ecotropic viral integration site-1 gene (EVI1/MECOM) marks the most lethal acute myeloid leukemia subgroup carrying 3q26 abnormalities. Here, pan-histone deacetylase inhibitors are identified as potent repressors of EVI1 and PA2G4 as a druggable target.

Grankvist et al. combine global isotopic tracing and metabolic flux modelling to characterize metabolic networks in human intact liver tissue.

The cancer therapeutic cetuximab blocks EGFR signaling on tumor cells. Pozzi et al. now show that this antibody, when combined with chemotherapy, can also kill colorectal cancer cells by triggering immunogenic cell death.

Combinatorial high-throughput methodologies can accelerate screening and discovery in biochemistry and biomedical sciences, but they often rely on large-scale analyses, making them time-consuming and expensive. Now, DNA-mediated fusion of single liposomes has been shown to enable the spatially resolved and parallel cargo delivery of subattolitre volumes in a stochastic order of succession.

Intracortical activity data recorded over 2 years in a tetraplegic patient is used to develop an artificial intelligence algorithm that achieves fast, accurate, and stable movement decoding to reenable real-time control of the paralyzed forearm.