Nature Search

p44/42 MAP kinase-dependent regulation of catalase by autocrine human growth hormone protects human mammary carcinoma cells from oxidative stress-induced apoptosis

Zhe Zhu
Svetlana Mukhina
Peter E Lobie
Research14 Mar 2005
Oncogene

Volume: 24, P: 3774-3785
Trefoil factor 3 promotes pancreatic carcinoma progression via WNT pathway activation mediated by enhanced WNT ligand expression

Feifei Cheng
Xuejuan Wang
Peter E. Lobie
ResearchOpen Access25 Mar 2022
Cell Death & Disease

Volume: 13, P: 1-13
Astrocyte-secreted cues promote neural maturation and augment activity in human forebrain organoids

Current brain organoids protocols face significant challenges in achieving adequate neural maturation to effectively replicate the functionality of mature neural circuits. Here, authors present an approach by integrating astrocyte-secreted factors to facilitate maturation and functional fidelity of in vitro brain organoids and planar neural cultures.

Honghui Zheng
Yilin Feng
Shaohua Ma
ResearchOpen Access23 Mar 2025
Nature Communications

Volume: 16, P: 1-19
Inhibition of TFF3 synergizes with c-MET inhibitors to decrease the CSC-like phenotype and metastatic burden in ER+HER2+ mammary carcinoma

Chuyu He
Xuejuan Wang
Peter E. Lobie
ResearchOpen Access07 Feb 2025
Cell Death & Disease

Volume: 16, P: 1-19
Bead-jet printing enabled sparse mesenchymal stem cell patterning augments skeletal muscle and hair follicle regeneration

Current mesenchymal stem cell (MSC) transplantation practices are limited by the loss or reduced performance of MSCs. Here the authors develop a bead-jet printer for intraoperative formulation and printing of MSCs-laden Matrigel beads to improve skeletal muscle and hair follicle regeneration.

Yuanxiong Cao
Jiayi Tan
Shaohua Ma
ResearchOpen Access03 Dec 2022
Nature Communications

Volume: 13, P: 1-21
Gd-metallofullerenol nanomaterial as non-toxic breast cancer stem cell-specific inhibitor

A metallofullerenol nanomaterial, Gd@C₈₂(OH)₂₂, was shown to inhibit growth of several solid cancers in preclinical models and yet exhibit low toxicity. Herein the authors show that Gd@C₈₂(OH)₂₂functions as an inhibitor of breast cancer stem cell function via blocking TGF-β and HIF-1α signalling, while sparing normal tissue.

Ying Liu
Chunying Chen
Yuliang Zhao
ResearchOpen Access23 Jan 2015
Nature Communications

Volume: 6, P: 1-18
Long-term pulmonary exposure to multi-walled carbon nanotubes promotes breast cancer metastatic cascades

In a breast cancer animal model, long-term exposure to carbon nanotubes promotes tumour invasiveness and metastasis through activation of local and systemic inflammation.

Xuefei Lu
Yong Zhu
Tao Zhu
Research24 Jun 2019
Nature Nanotechnology

Volume: 14, P: 719-727
EZH2-mediated PP2A inactivation confers resistance to HER2-targeted breast cancer therapy

Resistance to anti-HER2 therapies in breast cancer remains a significant clinical challenge. Here, the authors demonstrate that EZH2 regulates response to HER2-targeting therapies in breast cancer, in part, by modulating the expression of PPP2R2B.

Yi Bao
Gokce Oguz
Qiang Yu
ResearchOpen Access18 Nov 2020
Nature Communications

Volume: 11, P: 1-17
Cancer stem cell regulated phenotypic plasticity protects metastasized cancer cells from ferroptosis

The contribution of breast cancer stem cells (BCSCs) to metastasis needs further elucidation. Here, the authors show that BCSCs secrete DKK1 to protect metastasizing cancer cells from ferroptosis via upregulation of SLC7A11, and further show that the combination of a ferroptosis inducer with a DKK1 inhibitor reduces metastasis.

Mingming Wu
Xiao Zhang
Tao Zhu
ResearchOpen Access16 Mar 2022
Nature Communications

Volume: 13, P: 1-16
Reply to: “The non-cytotoxic small molecule NPB does not inhibit BAD phosphorylation and forms colloidal aggregates”

Xi Zhang
Basappa Basappa
Vijay Pandey
ResearchOpen Access30 Jul 2025
Communications Medicine

Volume: 5, P: 1-5
TFF3 facilitates dormancy of anti-estrogen treated ER+ mammary carcinoma

Chen et al. generate mimicking dormant clinical anti-estrogen-induced estrogen receptor positive mammary carcinoma (ER+MC) models. TFF3 is identified as a prognostic indicator and epigenetically regulated oncogenic driver of anti-estrogen-induced dormancy in ER+MC with combined inhibition of TFF3 and CDK4/6 exhibiting potential to ameliorate outcomes in anti-estrogen-induced ER+MC.

Shu Chen
Xi Zhang
Peter E. Lobie
ResearchOpen Access21 Feb 2025
Communications Medicine

Volume: 5, P: 1-17
TFF3 drives Hippo dependent EGFR-TKI resistance in lung adenocarcinoma

Shuwei Zhang
Yan Qin Tan
Peter E. Lobie
Research10 Dec 2024
Oncogene

Volume: 44, P: 753-768
LINC00460-FUS-MYC feedback loop drives breast cancer metastasis and doxorubicin resistance

Leiyan Yang
Miaomiao Wang
Tao Zhu
Research28 Feb 2024
Oncogene

Volume: 43, P: 1249-1262
Vertical pathway inhibition of receptor tyrosine kinases and BAD with synergistic efficacy in triple negative breast cancer

Yan Qin Tan
Yi-Shiou Chiou
Peter E. Lobie
ResearchOpen Access10 Jan 2024
npj Precision Oncology

Volume: 8, P: 1-19
Concurrent inhibition of pBADS99 synergistically improves MEK inhibitor efficacy in KRAS^G12D-mutant pancreatic ductal adenocarcinoma

Yan Qin Tan
Bowen Sun
Vijay Pandey
ResearchOpen Access26 Feb 2024
Cell Death & Disease

Volume: 15, P: 1-15
Combined inhibition of BADSer99 phosphorylation and PARP ablates models of recurrent ovarian carcinoma

Zhang et al. test the therapeutic potential of an inhibitor of BAD phosphorylation, NPB, in epithelial ovarian cancer. The authors show that the small molecule synergises with PARP inhibition to kill patient-derived ovarian cancer organoids and suppress the growth of xenograft tumours, including a cisplatin-resistant model.

Xi Zhang
Liqiong Wang
Vijay Pandey
ResearchOpen Access02 Jul 2022
Communications Medicine

Volume: 2, P: 1-16
A novel small-molecule inhibitor of trefoil factor 3 (TFF3) potentiates MEK1/2 inhibition in lung adenocarcinoma

Mengyi Zhang
Baocheng Wang
Peter E. Lobie
ResearchOpen Access04 Nov 2019
Oncogenesis

Volume: 8, P: 1-16
NUDT21 negatively regulates PSMB2 and CXXC5 by alternative polyadenylation and contributes to hepatocellular carcinoma suppression

Sheng Tan
Hua Li
Tao Zhu
Research21 May 2018
Oncogene

Volume: 37, P: 4887-4900
Inhibition of BAD-Ser99 phosphorylation synergizes with PARP inhibition to ablate PTEN-deficient endometrial carcinoma

Xi Zhang
Peng Huang
Vijay Pandey
ResearchOpen Access20 Jun 2022
Cell Death & Disease

Volume: 13, P: 1-12
SHON expression predicts response and relapse risk of breast cancer patients after anthracycline-based combination chemotherapy or tamoxifen treatment

Tarek M. A. Abdel-Fatah
Reuben J. Broom
Dong-Xu Liu
ResearchOpen Access28 Feb 2019
British Journal of Cancer

Volume: 120, P: 728-745
XIAP facilitates breast and colon carcinoma growth via promotion of p62 depletion through ubiquitination-dependent proteasomal degradation

Xing Huang
Xiao-nan Wang
Zhengsheng Wu
Research01 Oct 2018
Oncogene

Volume: 38, P: 1448-1460
Expression of two non-mutated genetic elements is sufficient to stimulate oncogenic transformation of human mammary epithelial cells

Vijay Pandey
Min Zhang
Peter E. Lobie
ResearchOpen Access19 Nov 2018
Cell Death & Disease

Volume: 9, P: 1-18
CCAR1 5′ UTR as a natural miRancer of miR-1254 overrides tamoxifen resistance

Gaopeng Li
Xiaoli Wu
Tao Zhu
ResearchOpen Access22 Mar 2016
Cell Research

Volume: 26, P: 655-673

Search

p44/42 MAP kinase-dependent regulation of catalase by autocrine human growth hormone protects human mammary carcinoma cells from oxidative stress-induced apoptosis

Trefoil factor 3 promotes pancreatic carcinoma progression via WNT pathway activation mediated by enhanced WNT ligand expression

Astrocyte-secreted cues promote neural maturation and augment activity in human forebrain organoids

Inhibition of TFF3 synergizes with c-MET inhibitors to decrease the CSC-like phenotype and metastatic burden in ER+HER2+ mammary carcinoma

Bead-jet printing enabled sparse mesenchymal stem cell patterning augments skeletal muscle and hair follicle regeneration

Gd-metallofullerenol nanomaterial as non-toxic breast cancer stem cell-specific inhibitor

Long-term pulmonary exposure to multi-walled carbon nanotubes promotes breast cancer metastatic cascades

EZH2-mediated PP2A inactivation confers resistance to HER2-targeted breast cancer therapy

Cancer stem cell regulated phenotypic plasticity protects metastasized cancer cells from ferroptosis

Reply to: “The non-cytotoxic small molecule NPB does not inhibit BAD phosphorylation and forms colloidal aggregates”

TFF3 facilitates dormancy of anti-estrogen treated ER+ mammary carcinoma

TFF3 drives Hippo dependent EGFR-TKI resistance in lung adenocarcinoma

LINC00460-FUS-MYC feedback loop drives breast cancer metastasis and doxorubicin resistance

Vertical pathway inhibition of receptor tyrosine kinases and BAD with synergistic efficacy in triple negative breast cancer

Concurrent inhibition of pBADS99 synergistically improves MEK inhibitor efficacy in KRAS^G12D-mutant pancreatic ductal adenocarcinoma

Combined inhibition of BADSer99 phosphorylation and PARP ablates models of recurrent ovarian carcinoma

A novel small-molecule inhibitor of trefoil factor 3 (TFF3) potentiates MEK1/2 inhibition in lung adenocarcinoma

NUDT21 negatively regulates PSMB2 and CXXC5 by alternative polyadenylation and contributes to hepatocellular carcinoma suppression

Inhibition of BAD-Ser99 phosphorylation synergizes with PARP inhibition to ablate PTEN-deficient endometrial carcinoma

SHON expression predicts response and relapse risk of breast cancer patients after anthracycline-based combination chemotherapy or tamoxifen treatment

XIAP facilitates breast and colon carcinoma growth via promotion of p62 depletion through ubiquitination-dependent proteasomal degradation

Expression of two non-mutated genetic elements is sufficient to stimulate oncogenic transformation of human mammary epithelial cells

CCAR1 5′ UTR as a natural miRancer of miR-1254 overrides tamoxifen resistance

Search

Quick links

Search

Filter By:

Search

Quick links