Riboswitches are RNA elements that provide feedback regulation of metabolic genes upon ligand binding. The glmS riboswitch is also a ribozyme, self-cleaving upon glucosamine-6-phosphate binding. By following intracellular self-cleavage under different growth conditions, it is now found that this riboswitch also responds to inhibitory metabolites, arguing that it integrates multiple signals in response to the metabolic status of the cell.
- Peter Y Watson
- Martha J Fedor
