Nature Search

Diminishing benefits of urban living for children and adolescents’ growth and development

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Anu Mishra
Bin Zhou
Majid Ezzati
ResearchOpen Access29 Mar 2023
Nature

Volume: 615, P: 874-883
A microRNA panel compared to environmental and polygenic scores for colorectal cancer risk prediction

Appropriate risk models could facilitate risk stratification for colorectal cancer (CRC) screening. Here, the authors propose a blood-based microRNA signature observed to have altered expression in pre-diagnostic samples, which might be useful to identify high-risk populations for colorectal cancer screening.

Janhavi R. Raut
Ben Schöttker
Hermann Brenner
ResearchOpen Access10 Aug 2021
Nature Communications

Volume: 12, P: 1-9
Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation

Previous studies identified an association between the 2q35 locus and breast cancer. Here, the authors show that a SNP at 2q35, rs4442975, is associated with oestrogen receptor positive disease and suggest that this effect is mediated through the downregulation of a known breast cancer gene, IGFBP5.

Maya Ghoussaini
Stacey L. Edwards
Anna De Fazio
Research23 Sept 2014
Nature Communications

Volume: 5, P: 1-12
Predicting colorectal cancer survival by combined c-reactive protein and tumor immune score

Tafirenyika Gwenzi
Durgesh Wankhede
Hermann Brenner
ResearchOpen Access25 Nov 2025
npj Precision Oncology

Volume: 9, P: 1-7
Neutralizing GDF-15 can overcome anti-PD-1 and anti-PD-L1 resistance in solid tumours

A study reporting the results of a clinical trial co-administering the GDF-15-blocking antibody visugromab with the anti-PD-1 antibody nivolumab demonstrates that neutralizing GDF-15 can overcome resistance to immune checkpoint inhibition in cancer.

Ignacio Melero
Maria de Miguel Luken
Eugen Leo
ResearchOpen Access11 Dec 2024
Nature

Volume: 637, P: 1218-1227
Repositioning of the global epicentre of non-optimal cholesterol

From 1980 to 2018, the levels of total and non-high-density lipoprotein cholesterol increased in low- and middle-income countries, especially in east and southeast Asia, and decreased in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe.

Cristina Taddei
Bin Zhou
Majid Ezzati
ResearchOpen Access03 Jun 2020
Nature

Volume: 582, P: 73-77
Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer

Oestrogen negative breast cancer is associated with a poor prognosis. In this study, the authors perform a meta-analysis of 11 breast cancer genome-wide association studies and identify four new loci associated with oestrogen negative breast cancer risk. These findings may aid in stratifying patients in the clinic.

Fergus J. Couch
Karoline B. Kuchenbaecker
Antonis C. Antoniou
ResearchOpen Access27 Apr 2016
Nature Communications

Volume: 7, P: 1-13
Global variation in diabetes diagnosis and prevalence based on fasting glucose and hemoglobin A1c

Analysis of HbA1c and FPG levels across 117 population-based studies demonstrates regional variation in prevalence of previously undiagnosed screen-detected diabetes using one or both measures and suggests that use of elevated FPG alone could underestimate diabetes prevalence in low- and middle-income countries.

Bin Zhou
Kate E. Sheffer
Majid Ezzati
ResearchOpen Access09 Nov 2023
Nature Medicine

Volume: 29, P: 2885-2901
Author Correction: Neutralizing GDF-15 can overcome anti-PD-1 and anti-PD-L1 resistance in solid tumours

Ignacio Melero
Maria de Miguel Luken
Eugen Leo
Amendments and CorrectionsOpen Access25 Feb 2025
Nature

Volume: 639, P: E18
Effects of LC-PUFA supply via complementary food on infant development—a food based intervention (RCT) embedded in a total diet concept

Hermann Kalhoff
Christina M. Mesch
Lars Libuda
Research05 Aug 2019
European Journal of Clinical Nutrition

Volume: 74, P: 682-690
Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer

Cross-study analysis defines fecal microbial species associated with colorectal cancer.

Jakob Wirbel
Paul Theodor Pyl
Georg Zeller
Research01 Apr 2019
Nature Medicine

Volume: 25, P: 679-689
Serum β-synuclein, neurofilament light chain and glial fibrillary acidic protein as prognostic biomarkers in moderate-to-severe acute ischemic stroke

Lorenzo Barba
Christoph Vollmuth
Markus Otto
ResearchOpen Access28 Nov 2023
Scientific Reports

Volume: 13, P: 1-7
Structure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M consensus sequence

Stabilized, native-like trimers of the HIV envelope protein, such as SOSIP trimers, are potential antigens for an HIV vaccine. Here, the authors generate a SOSIP trimer based on the consensus sequence of group M isolates, determine its structure and exposure of common epitopes, and show immunogenicity in rabbits and non-human primates.

Kwinten Sliepen
Byung Woo Han
Rogier W. Sanders
ResearchOpen Access29 May 2019
Nature Communications

Volume: 10, P: 1-16
The spleen in ischaemic heart disease

In this Review, Heusch and Kleinbongard describe the deleterious and protective roles of the spleen in the inflammatory processes of atherosclerosis, myocardial infarction and heart failure, and highlight the translational potential of the cardioprotective functions of the spleen for the treatment of patients with ischaemic heart disease.

Gerd Heusch
Petra Kleinbongard
Reviews02 Jan 2025
Nature Reviews Cardiology

Volume: 22, P: 497-509
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

Reduced glomerular filtration rate (eGFR) is a hallmark of chronic kidney disease. Here, Pattaro et al. conduct a meta-analysis to discover several new loci associated with variation in eGFR and find that genes associated with eGFR loci often encode proteins potentially related to kidney development.

Cristian Pattaro
Alexander Teumer
Caroline S. Fox
ResearchOpen Access21 Jan 2016
Nature Communications

Volume: 7, P: 1-19
Metagenomic analysis of colorectal cancer datasets identifies cross-cohort microbial diagnostic signatures and a link with choline degradation

Multicohort analysis identifies microbial signatures of colorectal cancer in fecal microbiomes.

Andrew Maltez Thomas
Paolo Manghi
Nicola Segata
Research01 Apr 2019
Nature Medicine

Volume: 25, P: 667-678
Mode-resolved reciprocal space mapping of electron-phonon interaction in the Weyl semimetal candidate Td-WTe₂

It is predicted that topological phase transitions in quantum materials can be triggered by selective excitation of coherent phonons. Upon excitation of a shear mode, Hein et al. observe distinct perturbations of electronic Weyl semimetal fingerprints in Td-WTe₂.

Petra Hein
Stephan Jauernik
Michael Bauer
ResearchOpen Access26 May 2020
Nature Communications

Volume: 11, P: 1-8
Selection and characterization of a high-activity ribozyme directed against the antineoplastic drug resistance–associated ABC transporter BCRP/MXR/ABCG2

Petra Kowalski
Anke Wichert
Hermann Lage
Research02 May 2001
Cancer Gene Therapy

Volume: 8, P: 185-192
A novel antibiotic class targeting the lipopolysaccharide transporter

A tethered macrocyclic peptide antibiotic class described here—which shows potent antibacterial activity against carbapenem-resistant Acinetobacter baumannii—blocks the transport of bacterial lipopolysaccharide from the inner membrane to its destination on the outer membrane through inhibition of the LptB₂FGC complex.

Claudia Zampaloni
Patrizio Mattei
Kenneth A. Bradley
ResearchOpen Access03 Jan 2024
Nature

Volume: 625, P: 566-571
DNA methylation-based classification of central nervous system tumours

An online approach for the DNA methylation-based classification of central nervous system tumours across all entities and age groups has been developed to help to improve current diagnostic standards.

David Capper
David T. W. Jones
Stefan M. Pfister
Research14 Mar 2018
Nature

Volume: 555, P: 469-474
Rising rural body-mass index is the main driver of the global obesity epidemic in adults

Contrary to the view that urbanization is a major driver of the global rise in obesity, the global increase in body-mass index is shown to be mostly due to increases in the body-mass indexes of rural populations.

Honor Bixby
James Bentham
Majid Ezzati
ResearchOpen Access08 May 2019
Nature

Volume: 569, P: 260-264
Correction: Publisher Correction: Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation

Maya Ghoussaini
Stacey L. Edwards
Alison M. Dunning
Amendments and Corrections10 Apr 2018
Nature Communications

Volume: 9, P: 1-2
Author Correction: Metagenomic analysis of colorectal cancer datasets identifies cross-cohort microbial diagnostic signatures and a link with choline degradation

Andrew Maltez Thomas
Paolo Manghi
Nicola Segata
Amendments and Corrections29 Oct 2019
Nature Medicine

Volume: 25, P: 1948
The cranium from the Octagon in Ephesos

Gerhard W. Weber
Petra G. Šimková
Ron Pinhasi
ResearchOpen Access10 Jan 2025
Scientific Reports

Volume: 15, P: 1-16
Operatic voices engage the default mode network in professional opera singers

Adél Bihari
Ádám Nárai
Zoltán Vidnyánszky
ResearchOpen Access12 Sept 2024
Scientific Reports

Volume: 14, P: 1-11
Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer

Doug Easton and colleagues report the results of a large-scale genome-wide association study of breast cancer. They discover 15 new susceptibility loci and highlight likely target genes in several of the newly associated regions.

Kyriaki Michailidou
Jonathan Beesley
Douglas F Easton
Research09 Mar 2015
Nature Genetics

Volume: 47, P: 373-380
Genome-wide association studies identify four ER negative–specific breast cancer risk loci

Montserrat Garcia-Closas and colleagues report a meta-analysis of three genome-wide association studies for estrogen receptor (ER)-negative breast cancer, including 4,193 ER-negative breast cancer cases and 35,194 controls, with replication using the iCOGS custom genotyping array in 40 studies, including 6,514 cases and 41,455 controls. They identify four loci associated with ER-negative but not ER-positive breast cancer.

Montserrat Garcia-Closas
Fergus J Couch
Peter Kraft
Research27 Mar 2013
Nature Genetics

Volume: 45, P: 392-398
The AP-1 transcription factor Fosl-2 drives cardiac fibrosis and arrhythmias under immunofibrotic conditions

The role of the transcription factor Fosl-2 in promoting myocardial fibrosis, arrhythmias and aberrant response to stress under immunofibrotic conditions is described using an in vivo mouse model and human cardiac fibroblasts.

Mara Stellato
Matthias Dewenter
Gabriela Kania
ResearchOpen Access09 Feb 2023
Communications Biology

Volume: 6, P: 1-15
p53 mutations in urinary bladder cancer

P Berggren
G Steineck
K Hemminki
ResearchOpen Access29 May 2001
British Journal of Cancer

Volume: 84, P: 1505-1511
The dynamics of resting fluctuations in the brain: metastability and its dynamical cortical core

Gustavo Deco
Morten L. Kringelbach
Petra Ritter
ResearchOpen Access08 Jun 2017
Scientific Reports

Volume: 7, P: 1-14
Characterisation of the novel spontaneously immortalized and invasively growing human skin keratinocyte line HaSKpw

Elizabeth Pavez Lorie
Nicola Stricker
Alexander Rapp
ResearchOpen Access16 Sept 2020
Scientific Reports

Volume: 10, P: 1-20
Prognostic value of post-operative iron biomarkers in colorectal cancer: population-based patient cohort

Tafirenyika Gwenzi
Petra Schrotz-King
Hermann Brenner
ResearchOpen Access27 Aug 2024
British Journal of Cancer

Volume: 131, P: 1195-1201
Movement-related artefacts (MR-ART) dataset of matched motion-corrupted and clean structural MRI brain scans

Ádám Nárai
Petra Hermann
Zoltán Vidnyánszky
ResearchOpen Access17 Oct 2022
Scientific Data

Volume: 9, P: 1-6
Fragment screening using biolayer interferometry reveals ligands targeting the SHP-motif binding site of the AAA+ ATPase p97

The AAA+ ATPase p97 protein is thought to be a potential anticancer target, but direct targeting on its ATPase function has not proven to be a successful strategy in clinical trials due to lack of selectivity. Here, the authors use biolayer interferometry-based fragment screening to identify ligands for the development of protein-protein interaction inhibitors by targeting the SHP-motif as a cofactor binding site in the N-domain of p97.

Sebastian Bothe
Petra Hänzelmann
Christoph Sotriffer
ResearchOpen Access07 Dec 2022
Communications Chemistry

Volume: 5, P: 1-15
GCSH antisense regulation determines breast cancer cells’ viability

Anna Adamus
Petra Müller
Nadja Engel
ResearchOpen Access18 Oct 2018
Scientific Reports

Volume: 8, P: 1-13
Modulation of the atypical multidrug-resistant phenotype by a hammerhead ribozyme directed against the ABC transporter BCRP/MXR/ABCG2

Petra Kowalski
Ulrike Stein
Hermann Lage
Research14 Jun 2002
Cancer Gene Therapy

Volume: 9, P: 579-586
Multi-proxy record of the Austrian Upper Triassic Polzberg Konservat-Lagerstätte in light of the Carnian Pluvial Episode

Alexander Lukeneder
Petra Lukeneder
Manuel Rigo
ResearchOpen Access21 May 2024
Scientific Reports

Volume: 14, P: 1-21
Effect of head motion-induced artefacts on the reliability of deep learning-based whole-brain segmentation

Péter Kemenczky
Pál Vakli
Zoltán Vidnyánszky
ResearchOpen Access31 Jan 2022
Scientific Reports

Volume: 12, P: 1-13
Diagnosing congenital malaria in a high-transmission setting: clinical relevance and usefulness of P. falciparum HRP2-based testing

Hamtandi Magloire Natama
Delwendé Florence Ouedraogo
Anna Rosanas-Urgell
ResearchOpen Access18 May 2017
Scientific Reports

Volume: 7, P: 1-10
Risk factors cannot explain the higher prevalence rates of precancerous colorectal lesions in men

Elisabeth Waldmann
Georg Heinze
Monika Ferlitsch
ResearchOpen Access20 Oct 2016
British Journal of Cancer

Volume: 115, P: 1421-1429
Epidemiology of 7375 children and adolescents hospitalized with COVID-19 in Germany, reported via a prospective, nationwide surveillance study in 2020–2022

Maren Doenhardt
Markus Hufnagel
Ulrich Zügge
ResearchOpen Access02 Jan 2024
Scientific Reports

Volume: 14, P: 1-15
CD147 a direct target of miR-146a supports energy metabolism and promotes tumor growth in ALK+ ALCL

Ivonne-Aidee Montes-Mojarro
Julia Steinhilber
Leticia Quintanilla-Martinez
ResearchOpen Access08 Jun 2022
Leukemia

Volume: 36, P: 2050-2063
Taphonomic history and trophic interactions of an ammonoid fauna from the Upper Triassic Polzberg palaeobiota

Alexander Lukeneder
Petra Lukeneder
ResearchOpen Access06 May 2022
Scientific Reports

Volume: 12, P: 1-14
Elucidating membrane structure and protein behavior using giant plasma membrane vesicles

Erdinc Sezgin
Hermann-Josef Kaiser
Ilya Levental
Protocols03 May 2012
Nature Protocols

Volume: 7, P: 1042-1051
The pathological features of angioimmunoblastic T-cell lymphomas with IDH2^R172 mutations

Julia Steinhilber
Moritz Mederake
Leticia Quintanilla-Martinez
Research05 Apr 2019
Modern Pathology

Volume: 32, P: 1123-1134
A comparison of pediatric inflammatory multisystem syndrome temporarily-associated with SARS-CoV-2 and Kawasaki disease

Markus Hufnagel
Jakob Armann
Ulrich Zügge
ResearchOpen Access20 Jan 2023
Scientific Reports

Volume: 13, P: 1-14
Identification of regulatory variants associated with genetic susceptibility to meningococcal disease

Lisa Borghini
Eileen Png
Peter Schermann
ResearchOpen Access06 May 2019
Scientific Reports

Volume: 9, P: 1-15
Inhibition abilities and functional brain connectivity in school-aged term-born and preterm-born children

Vera Disselhoff
Andras Jakab
Petra Hüppi
ResearchOpen Access19 Jun 2024
Pediatric Research

Volume: 97, P: 315-324
The chemokine receptor CXCR3 limits injury after acute toxic liver damage

Mirko Moreno Zaldivar
Marie-Luise Berres
Hermann E Wasmuth
Research19 Mar 2012
Laboratory Investigation

Volume: 92, P: 724-734
BIRC5/Survivin enhances aerobic glycolysis and drug resistance by altered regulation of the mitochondrial fusion/fission machinery

J Hagenbuchner
A V Kuznetsov
M J Ausserlechner
Research12 Nov 2012
Oncogene

Volume: 32, P: 4748-4757

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