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Showing 1–11 of 11 results
Advanced filters: Author: Philipp Rauch Clear advanced filters

  • Rauch et al. show that loss-of-function mutations in the epigenetic regulator Dnmt3a lead to accelerated atherosclerosis, as previously shown for Tet2, and that loss of either gene leads to similar changes in atheroma composition, with the emergence of a distinct population of chemokine-enriched, resident-like macrophages infiltrating the adventitia, as revealed by single-cell transcriptomics and spatial proteomic analyses.

    • Philipp J. Rauch
    • Jayakrishnan Gopakumar
    • Siddhartha Jaiswal
    Research
    Nature Cardiovascular Research
    Volume: 2, P: 805-818

  • Endogenous retroviruses (ERV) can induce immune responses and the control of these viruses uses immune mechanisms also involved in autoimmunity. Here, the authors characterize the control of ERVs in mice and show age-associated B cell control and nucleic acid sensing TLR pathway involvement.

    • Eileen Rauch
    • Timm Amendt
    • Philipp Yu
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-19

  • In a cluster-randomized trial conducted across 70 medical centers in six countries, a 16-week structured educational program for healthcare providers improved adherence to guidelines for rhythm control but not for stroke prevention in individuals with atrial fibrillation.

    • Dipak Kotecha
    • Karina V. Bunting
    • Paulus Kirchhof
    ResearchOpen Access
    Nature Medicine
    Volume: 31, P: 2647-2654

  • Severity of SARS-CoV-2 infection is different in adults and children which involves the immune response. Here using a parent and children cohort with 4 month and 12 month sampling times, the authors show enhanced levels and increased breadth of anti-spike antibody level over time but reduced specific T cell and B cell numbers in children.

    • Eva-Maria Jacobsen
    • Dorit Fabricius
    • Ales Janda
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • Novae are caused by runaway thermonuclear burning in the hydrogen-rich envelopes of accreting white dwarfs, which leads to a rapid expansion of the envelope and the ejection of most of its mass1,2. Theory has predicted the existence of a ‘fireball’ phase following directly on from the runaway fusion, which should be observable as a short, bright and soft X-ray flash before the nova becomes visible in the optical3–5. Here we report observations of a bright and soft X-ray flash associated with the classical Galactic nova YZ Reticuli 11 h before its 9 mag optical brightening. No X-ray source was detected 4 h before and after the event, constraining the duration of the flash to shorter than 8 h. In agreement with theoretical predictions4,6–8, the source’s spectral shape is consistent with a black-body of 3.27+0.11−0.33 × 105 K (28.2+0.9−2.8 eV), or a white dwarf atmosphere, radiating at the Eddington luminosity, with a photosphere that is only slightly larger than a typical white dwarf.

    • Ole König
    • Jörn Wilms
    • Klaus Werner
    Research
    Nature
    Volume: 605, P: 248-250

  • Self-assembly of DNA origami is a complex folding problem without a unified view of the energetic factors involved. Here the authors analyse identical structures that differ by nucleotide sequence and identify how mechanical stress at nucleation sites shapes the energy landscape.

    • Richard Kosinski
    • Ann Mukhortava
    • Barbara Saccà
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12

  • The genetic basis of metabolic diseases is incompletely understood. Here, by high-throughput phenotyping of 2,016 knockout mouse strains, Rozman and colleagues identify candidate metabolic genes, many of which are associated with unexplored regulatory gene networks and metabolic traits in human GWAS.

    • Jan Rozman
    • Birgit Rathkolb
    • Martin Hrabe de Angelis
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-16

  • Friedrich Luft and colleagues identify missense mutations in PDE3A in six unrelated families with an autosomal dominant syndrome marked by severe hypertension and brachydactyly. They further show that the mutations result in gain of enzymatic function, leading to increased vascular smooth muscle cell proliferation and vessel wall hyperplasia.

    • Philipp G Maass
    • Atakan Aydin
    • Sylvia Bähring
    Research
    Nature Genetics
    Volume: 47, P: 647-653