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Electron microscopy analysis of FcRγ localization after its capture by T cells by trogocytosis

Stephanie Balor
Marc Daëron
Denis Hudrisier
ResearchOpen Access05 Oct 2009
Nature Precedings

P: 1
An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence

Lee et al. report an engineered IgG1 Fc domain that behaves like an hFcRn binding pH toggle switch. The authors show that this new half-life extension Fc domain confers improved pharmacokinetics in new humanized knock-in mouse strains that recapitulate the key processes for antibody persistence in circulation.

Chang-Han Lee
Tae Hyun Kang
George Georgiou
ResearchOpen Access06 Nov 2019
Nature Communications

Volume: 10, P: 1-11
Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors

Both environmental factors and genetic factors influence human immunity. Albert and colleagues leverage data from the Milieu Intérieur Consortium to comprehensively describe the effects of lifestyle, environment and genetics on human innate and adaptive immunity.

Etienne Patin
Milena Hasan
Matthew L. Albert
Research23 Feb 2018
Nature Immunology

Volume: 19, P: 302-314
DNA methylation protects cancer cells against senescence

Using degron approaches, the authors show that cancer cells experiencing prolonged DNA methylation loss—without substantial DNA damage—undergo non-canonical senescence. This has important potential implications for cancer treatment.

Xiaoying Chen
Kosuke Yamaguchi
Pierre-Antoine Defossez
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-22
Erratum: The function of Fcγ receptors in dendritic cells and macrophages

Martin Guilliams
Pierre Bruhns
Bart N. Lambrecht
Amendments and Corrections07 Apr 2014
Nature Reviews Immunology

Volume: 14, P: 349
Author Correction: High-throughput single-cell activity-based screening and sequencing of antibodies using droplet microfluidics

Annabelle Gérard
Adam Woolfe
Colin Brenan
Amendments and Corrections22 May 2020
Nature Biotechnology

Volume: 38, P: 756
Correction: Corrigendum: IgG Fc domains that bind C1q but not effector Fcγ receptors delineate the importance of complement-mediated effector functions

Chang-Han Lee
Gabrielle Romain
George Georgiou
Amendments and Corrections19 Sept 2017
Nature Immunology

Volume: 18, P: 1173
Dual vaccination against IL-4 and IL-13 protects against chronic allergic asthma in mice

Asthma is caused by hyperreactivity to benign antigens, with humoral immunity orchestrated by interleukin-4 (IL-4) and IL-13 being the key etiological factor. Here the authors show, in humanized mouse models, that dual vaccination against IL-4 and IL-13 induces their durable suppression ameliorate experimental asthma, and to hint clinical translation.

Eva Conde
Romain Bertrand
Laurent L. Reber
ResearchOpen Access11 May 2021
Nature Communications

Volume: 12, P: 1-14
Publisher Correction: An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence

Chang-Han Lee
Tae Hyun Kang
George Georgiou
Amendments and CorrectionsOpen Access26 Nov 2019
Nature Communications

Volume: 10, P: 1
High-throughput single-cell activity-based screening and sequencing of antibodies using droplet microfluidics

Millions of primary IgG-secreting cells from mouse and human are characterized for activity and antibody sequence at the single-cell level.

Annabelle Gérard
Adam Woolfe
Colin Brenan
Research30 Mar 2020
Nature Biotechnology

Volume: 38, P: 715-721
Single-cell deep phenotyping of IgG-secreting cells for high-resolution immune monitoring

An in-droplet immunoassay enables determination of the rate and affinity of secreted antigen-specific antibodies at the single-cell level.

Klaus Eyer
Raphaël C L Doineau
Jean Baudry
Research11 Sept 2017
Nature Biotechnology

Volume: 35, P: 977-982
IgG Fc domains that bind C1q but not effector Fcγ receptors delineate the importance of complement-mediated effector functions

Monoclonal antibody (mAb) therapy is now commonplace in the clinic, yet such reagents can elicit unwanted side effects due to interactions with Fcγ receptors. Georgiou and colleagues have engineered mAbs that lack such FcγR interactions but retain the ability to activate complement and show that these modified mAbs have efficacious effector function.

Chang-Han Lee
Gabrielle Romain
George Georgiou
Research12 Jun 2017
Nature Immunology

Volume: 18, P: 889-898
Evidence that neutrophils do not promote Echis carinatus venom-induced tissue destruction

Julien Stackowicz
Bianca Balbino
Laurent L. Reber
CorrespondenceOpen Access13 Jun 2018
Nature Communications

Volume: 9, P: 1-3
Smoking changes adaptive immunity with persistent effects

A survey of 136 factors that may influence cytokine secretion identify smoking, cytomegalovirus latent infection and body mass index as influential factors, with varying effects on innate and adaptive immunity.

Violaine Saint-André
Bruno Charbit
Christophe Zimmer
ResearchOpen Access14 Feb 2024
Nature

Volume: 626, P: 827-835
Investigation of the sero-epidemiology of vaccine preventable diseases and common viral infections in French populations

Bloch et al., develop a high-throughput multiplex serological assay using bead-based Luminex technology to measure antibodies to a broad panel of vaccine-preventable diseases and common viral infections. They find a high level of population-level immunity to respiratory viruses and vaccine-preventable diseases, but with some notable immunity gaps in young children.

Emma Bloch
Gaëlle Baudemont
Michael White
ResearchOpen Access13 Nov 2025
Communications Medicine

Volume: 5, P: 1-11
The influence of environment on bacterial co-abundance in the gut microbiomes of healthy human individuals

Co-abundance analysis of 938 healthy individuals uncovers how host factors shape gut microbiome interactions, highlighting a core set of 200 impacted genera and additional factor-specific interactions.

Christophe Boetto
Violeta Basten Romero
Hugues Aschard
ResearchOpen Access06 Nov 2025
Communications Biology

Volume: 8, P: 1-11
The immune factors driving DNA methylation variation in human blood

Many studies assess epigenetic marks in white blood cells, but it is unclear how much immune factors affect the epigenome. Here, the authors show that fine-scale blood cell composition and cytomegalovirus infection affect the DNA methylome of adults.

Jacob Bergstedt
Sadoune Ait Kaci Azzou
Lluis Quintana-Murci
ResearchOpen Access06 Oct 2022
Nature Communications

Volume: 13, P: 1-20
The function of Fcγ receptors in dendritic cells and macrophages

Here, the authors review the expression patterns and function of Fc receptors for IgG (FcγRs) on conventional dendritic cells (DCs), monocyte-derived DCs, plasmacytoid DCs and macrophages in the steady state and at sites of inflammation. They also discuss emerging concepts and areas that require further investigation.

Martin Guilliams
Pierre Bruhns
Bart N. Lambrecht
Reviews21 Jan 2014
Nature Reviews Immunology

Volume: 14, P: 94-108
Parallel derivation of isogenic human primed and naive induced pluripotent stem cells

Derivation of human induced pluripotent stem cells (hiPSCs) produces primed hiPSCs that can in turn be converted to naive hiPSCs. Here, the authors directly reprogram somatic cells to form both naive and primed isogenic hiPSCs and confirm the similarity of naive hiPSCs to their in vivo counterparts.

Stéphanie Kilens
Dimitri Meistermann
Matthew L. Albert
ResearchOpen Access24 Jan 2018
Nature Communications

Volume: 9, P: 1-13
Rhesus negative males have an enhanced IFNγ-mediated immune response to influenza A virus

Jamie A. Sugrue
Megan Smith
Cliona O’Farrelly
ResearchOpen Access15 Apr 2022
Genes & Immunity

Volume: 23, P: 93-98
Deep phenotypic characterization of immunization-induced antibacterial IgG repertoires in mice using a single-antibody bioassay

Millie Heo et al. report a quantitative assessment of the immunization-induced antibacterial IgG repertoire in mice at single-antibody resolution. They find that immunization with multiple strains of heat-killed bacteria results in higher frequencies of bacteria-binding IgG, but with the tradeoff of lower binding affinities.

Millie Heo
Guilhem Chenon
Klaus Eyer
ResearchOpen Access26 Oct 2020
Communications Biology

Volume: 3, P: 1-11
Dynamic single-cell phenotyping of immune cells using the microfluidic platform DropMap

This protocol describes a microfluidic platform for dynamic high-throughput analysis of the phenotypes of single cells. Cell-surface markers and secreted proteins are quantified and characterized by fluorescence detection using tailored immunoassays.

Yacine Bounab
Klaus Eyer
Christophe Védrine
Protocols12 Aug 2020
Nature Protocols

Volume: 15, P: 2920-2955
Innate Immune Basis for Rift Valley Fever Susceptibility in Mouse Models

Rashida Lathan
Dominique Simon-Chazottes
Jean-Jacques Panthier
ResearchOpen Access02 Aug 2017
Scientific Reports

Volume: 7, P: 1-11
Human IgG1 antibodies suppress angiogenesis in a target-independent manner

Sasha Bogdanovich
Younghee Kim
Jayakrishna Ambati
ResearchOpen Access28 Jan 2016
Signal Transduction and Targeted Therapy

Volume: 1, P: 1-14

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Electron microscopy analysis of FcRγ localization after its capture by T cells by trogocytosis

An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence

Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors

DNA methylation protects cancer cells against senescence

Erratum: The function of Fcγ receptors in dendritic cells and macrophages

Author Correction: High-throughput single-cell activity-based screening and sequencing of antibodies using droplet microfluidics

Correction: Corrigendum: IgG Fc domains that bind C1q but not effector Fcγ receptors delineate the importance of complement-mediated effector functions

Dual vaccination against IL-4 and IL-13 protects against chronic allergic asthma in mice

Publisher Correction: An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence

High-throughput single-cell activity-based screening and sequencing of antibodies using droplet microfluidics

Single-cell deep phenotyping of IgG-secreting cells for high-resolution immune monitoring

IgG Fc domains that bind C1q but not effector Fcγ receptors delineate the importance of complement-mediated effector functions

Evidence that neutrophils do not promote Echis carinatus venom-induced tissue destruction

Smoking changes adaptive immunity with persistent effects

Investigation of the sero-epidemiology of vaccine preventable diseases and common viral infections in French populations

The influence of environment on bacterial co-abundance in the gut microbiomes of healthy human individuals

The immune factors driving DNA methylation variation in human blood

The function of Fcγ receptors in dendritic cells and macrophages

Parallel derivation of isogenic human primed and naive induced pluripotent stem cells

Rhesus negative males have an enhanced IFNγ-mediated immune response to influenza A virus

Deep phenotypic characterization of immunization-induced antibacterial IgG repertoires in mice using a single-antibody bioassay

Dynamic single-cell phenotyping of immune cells using the microfluidic platform DropMap

Innate Immune Basis for Rift Valley Fever Susceptibility in Mouse Models

Human IgG1 antibodies suppress angiogenesis in a target-independent manner

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