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Showing 1–2 of 2 results
Advanced filters: Author: Pierre Mesdom Clear advanced filters

  • New strategies to synthesise metal-based anticancer agents are critical for advancing chemotherapy. Here, the authors apply click chemistry to derive copper complexes that induce DNA strand breaks in recalcitrant cancer cells, validating an innovative route for metallodrug design.

    • Alex Gibney
    • Margareth Sidarta
    • Andrew Kellett
    ResearchOpen Access
    Nature Communications
    P: 1-15

  • Hepatic steatosis is prevalent in individuals with obesity and is a risk factor for type 2 diabetes mellitus. In this Review, the authors discuss the disruption of endoplasmic reticulum function in hepatic steatosis and how cellular stress responses to lipid accumulation can promote or inhibit progression to severe liver pathologies.

    • Andrei Baiceanu
    • Pierre Mesdom
    • Fabienne Foufelle
    Reviews
    Nature Reviews Endocrinology
    Volume: 12, P: 710-722