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Showing 1–8 of 8 results
Advanced filters: Author: Pierre O. Fiset Clear advanced filters

  • Mapping of the neutrophil compartment using single-cell transcriptional data from multiple physiological and patological states reveals its organizational architecture and how cell state dynamics and trajectories vary during health, inflammation and cancer.

    • Daniela Cerezo-Wallis
    • Andrea Rubio-Ponce
    • Iván Ballesteros
    ResearchOpen Access
    Nature
    Volume: 649, P: 1003-1012

  • The spatial architecture of the lung cancer microenvironment could influence the survival outlook and therapeutic options of patients. Here the authors find distinct patterns and composition of immune cells when comparing lung adenocarcinomas and lung squamous cell carcinomas, paving way for precision immune therapy according to histological subtype.

    • Lysanne Desharnais
    • Mark Sorin
    • Logan A. Walsh
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12

  • Using imaging mass cytometry, the tumour and immunological spatial landscapes of 416 lung adenocarcinomas are characterized, which, when combined with deep learning, can predict clinical outcomes with high accuracy.

    • Mark Sorin
    • Morteza Rezanejad
    • Logan A. Walsh
    ResearchOpen Access
    Nature
    Volume: 614, P: 548-554

  • Non-small cell lung cancers with inactivating SMARCA4 mutations are currently undruggable. Here, the authors show that the absence of SMARCA4/2 reduces chromatin accessibility at the CCND1 locus, leading to a subsequent reduction in cyclin D1 expression, which promotes vulnerability of these cancers to CDK4/6 inhibition.

    • Yibo Xue
    • Brian Meehan
    • Sidong Huang
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • SMARCA4/2 loss in ovarian and lung cancers is associated with chemotherapy resistance. Here, the authors show that SMARCA4/2 deficiency in cancer cells reduces the expression of the ER-Ca2+ channel IP3R3 and subsequently calcium transfer to the mitochondria, which inhibits apoptotic cell death.

    • Yibo Xue
    • Jordan L. Morris
    • Sidong Huang
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17