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Showing 1–7 of 7 results
Advanced filters: Author: Pieter Evenepoel Clear advanced filters

  • Oral phosphate binder therapy is considered a 'tower of strength' in the ever-expanding armamentarium of drugs used to treat abnormal mineral metabolism in patients with chronic kidney disease (CKD) and use of these agents early in the course of CKD is gaining much interest. Recent data from a randomized controlled study by Block et al. challenge this strategy, raise doubts about its safety and indicate the need for additional studies of hard end points.

    • Pieter Evenepoel
    • Bjorn Meijers
    News & Views
    Nature Reviews Nephrology
    Volume: 8, P: 615-616

  • This Review provides a guide to metabolite retention in kidney disease and includes an overview of key uraemic toxins and the complex mechanisms underlying their toxicity, as well as a discussion of key strategies with the potential to prevent or mitigate their adverse effects.

    • Griet Glorieux
    • Stéphane Burtey
    • Raymond Vanholder
    Reviews
    Nature Reviews Nephrology
    Volume: 22, P: 50-68

  • This Review examines the role of alterations in the gut microbial ecosystem, as well as inflammation and oxidative stress, in the bone and mineral disorder that affects patients with chronic kidney disease. The authors also explore novel therapeutic options that can target these disease factors.

    • Pieter Evenepoel
    • Peter Stenvinkel
    • Roberto Pacifici
    Reviews
    Nature Reviews Nephrology
    Volume: 19, P: 646-657

  • Here, the authors discuss the mechanisms by which food and specific nutrients could affect the uraemic phenotype in chronic kidney disease (CKD). They suggest that a food-as-medicine approach could potentially be used to prevent and treat CKD and its complications.

    • Denise Mafra
    • Natalia A. Borges
    • Peter Stenvinkel
    Reviews
    Nature Reviews Nephrology
    Volume: 17, P: 153-171

  • The microbiome is increasingly recognized as an element that contributes to health and disease. Here, the authors take an ecological approach to describe the impact of factors related to chronic kidney disease on the fitness of different physiological systems and the effects of these changes on microbiota composition.

    • Björn Meijers
    • Pieter Evenepoel
    • Hans-Joachim Anders
    Reviews
    Nature Reviews Nephrology
    Volume: 15, P: 531-545