Deoxyhypusine synthase (DHS) is central to hypusination and plays an important role in cellular physiology and disease, yet strategies to modulate its activity and regulate the hypusination process remain largely lacking despite detailed knowledge of its enzymatic mechanism. Here, the authors employ crystallographic fragment screening to identify fragments with the potential to regulate DHS, revealing their binding sites and underlying regulatory mechanisms.
- Piotr Wilk
- Elżbieta Wątor-Wilk
- Przemysław Grudnik
