Search

The symmetry of Cooper pairs in iron-based superconductors is an issue under continued investigation. A scanning tunnelling study of Fe(Te,Se) reveals a robust zero-energy bound state, providing evidence for a non-trivial pairing symmetry.

Chiea Chuen Khor, Tin Aung, Francesca Pasutto, Janey Wiggs and colleagues report a global genome-wide association study of exfoliation syndrome and a fine-mapping analysis of a previously identified disease-associated locus, LOXL1. They identify a rare protective variant in LOXL1 exclusive to the Japanese population and five new common variant susceptibility loci.

Insight-HXMT detected a double-peaked X-ray burst from Galactic magnetar SGR J1935+2154, consistent with two fast radio bursts (FRBs) observed from the same object within seconds. This coincidence suggests a common physical origin, and gives insight into the mechanism behind the origin of FRBs.

Obesity changes the characteristics of the immune response induced in a mouse model of atopic dermatitis, suggesting therapies that could be used against immune dysregulation in obesity.

An unbiased approach for the genome-wide detection of off-target cleavage by CRISPR-Cas9 RNA–guided nucleases reveals wide variability in the off-target activity of different guide RNAs.

An 8-hour radio observational campaign of the Galactic magnetar SGR 1935+2154, assisted by multi-wavelength data, indicates that associations between fast radio bursts and soft γ-ray bursts are rare.

The LHCb collaboration reports an improved measurement of the oscillation frequency of mesons consisting of a bottom quark and strange quark, which is then combined with previous results.

The decay asymmetry and helicity phase of polarized baryon–antibaryon pairs are measured at the BESIII experiment, testing charge–parity symmetry and revealing a discrepancy of the Λ → pπ⁻ decay asymmetry with respect to the current world average.

Large language models remain largely unexplored is the design of cities. In this Perspective, the authors discuss the potential opportunities brought by these models in assisting urban planning.

Nanoscale materials often exhibit size-dependent behaviour. Here, the authors use electron microscopy to quantitatively study the size-related dynamics of amorphous metallic nanoparticles, finding that particles below a critical size are in a supercooled liquid state at room temperature, with a viscosity much lower than that of bulk glasses.

Technical advancements have significantly improved early diagnosis of cervical cancer, but accurate diagnosis is still difficult due to various practical factors. Here, the authors develop an artificial intelligence assistive diagnostic solution to improve cervical liquid-based thin-layer cell smear diagnosis according to clinical TBS criteria in a large multicenter study.

Segregating glutamate receptor trafficking function from the changes in synaptic spine morphology, this study finds that actin depolymerizing factor (ADF)- and cofilin-mediated actin dynamics control AMPAR trafficking during chemically induced long-term potentiation independent of actin's structural role.

Lee and colleagues demonstrate that actin depolarizing factor (ADF)/cofilin regulates, and is required for, the insertion of acetylcholine receptors (AChRs) into the postsynaptic membrane at neuromuscular synapses. ADF/cofilin also appears to stabilize membrane AChRs; it associates with AChR clusters and disappears before the clusters themselves disassemble.

The photochemical electrocyclic ring-opening of 1,3-cyclohexadiene is a textbook organic chemistry reaction. Now, using ultrafast electron diffraction its reaction pathway has been resolved on the level of atomic distances and on its natural femtosecond timescale. Furthermore, coherent isomerization dynamics of the photoproduct 1,3,5-hexatriene were observed.

An ambipolar ferromagnet with both electron- and hole-doped ferromagnetism in a single material would facilitate understanding of ferromagnetic semiconductors for spintronic applications. Here the authors demonstrate ambipolar ferromagnetism in LaMnO₃, using ionic liquid gating enabled electrostatic doping to produce electron–hole asymmetry.

Analysis of mitochondrial genomes (mtDNA) by using whole-genome sequencing data from 2,658 cancer samples across 38 cancer types identifies hypermutated mtDNA cases, frequent somatic nuclear transfer of mtDNA and high variability of mtDNA copy number in many cancers.

Efficient, large-scale genomic analysis is facilitated on the cloud by a computational tool with error-diagnosing and self-healing capabilities.

A high-fidelity variant of Streptococcus pyogenes CRISPR–Cas9 is reported that lacks detectable off-target events as assessed by genome-wide break capture and targeted sequencing methods.

The measurement of the total cross-section of proton–proton collisions is of fundamental importance for particle physics. Here, the first measurement of the inelastic cross-section is presented for proton–proton collisions at an energy of 7 teraelectronvolts using the ATLAS detector at the Large Hadron Collider.

Analysis of whole-genome sequencing data across 2,658 tumors spanning 38 cancer types shows that chromothripsis is pervasive, with a frequency of more than 50% in several cancer types, contributing to oncogene amplification, gene inactivation and cancer genome evolution.

Fully quantifying the influence of vegetation on atmospheric chemistry remains challenging. Here, the authors show that forest canopy shading and turbulence significantly modify air pollution throughout the atmospheric boundary layer, and must be taken into account in models of the atmosphere.

The nature of the superconductivity in the kagome metals AV₃Sb₅ (A = K, Rb, Cs) remains under debate. Here, using muon spin spectroscopy, the authors find that the superconductivity in RbV₃Sb₅ and KV₃Sb₅ evolves from nodal to nodeless with increasing pressure and the superconducting state breaks time-reversal symmetry after suppression of the charge order.

X-ray crystal structures of a voltage-gated Na⁺channel mutated to be highly Ca²⁺selective provide a framework for understanding the mechanisms of ion selectivity and conductance in vertebrate voltage-gated Ca²⁺channels.

Relatives of patients with amyotrophic lateral sclerosis have an unexpectedly high incidence of schizophrenia. Here, the authors show a genetic link between the two conditions, suggesting shared neurobiological mechanisms.

Observations of an X-ray transient associated with a galaxy at redshift 0.738 suggest that the X-ray transient is powered by a millisecond magnetar and that it is the remnant of a merger between two neutron stars.

Mimicking biosynthetic pathways can provide access to medicinally important natural products, but generating the reactive species used by nature can often be difficult. Now, a photoredox-based strategy has been developed to access a reactive radical intermediate postulated to be involved in complex lignan biosynthesis.