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Showing 1–2 of 2 results
Advanced filters: Author: Qin-Li Wan Clear advanced filters

  • For proper mitochondrial inheritance, paternal sperm mitochondria must be eliminated. Here, authors identify ALKB-1 mediated tRNA demethylation as essential for this clearance in Caenorhabditis elegans, revealing an epitranscriptomic quality checkpoint tied to male fertility.

    • Zhenhuan Luo
    • Yimin Li
    • Qinghua Zhou
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-18

  • Transgenerational inheritance (TEI) mechanisms are to some extent conserved across species, but how TEI mediates lipid accumulation is unknown. Here the authors reveal that a network of lipid metabolic genes and chromatin modifications mediated by transcription factors and H3K4 trimethylation work together to achieve multigenerational obesogenic effects in C. elegans fed with a high-fat diet.

    • Qin-Li Wan
    • Xiao Meng
    • Qinghua Zhou
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-14