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Showing 1–2 of 2 results
Advanced filters: Author: Qing-Ping Xiong Clear advanced filters

  • mRNA modifications like m5C are typically introduced by tRNA-modifying enzymes, while the catalytic mechanism and function remain debated. Here, the authors show that NSUN6 catalyzes tRNA and mRNA substrates in different ways, and that NSUN6 promotes breast cancer cell migration through mRNA m5C modification.

    • Yuan-Yuan Zhang
    • Cai-Tao Li
    • Ru-Juan Liu
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19

  • Zhang et al. identify ALKBH7 as the demethylase of mitochondrial pre-tRNAs that regulates nascent mitochondrial RNA processing and translation. ALKBH7 loss impairs mitochondrial functions including fatty acid oxidation, leading to obesity.

    • Li-Sheng Zhang
    • Qing-Ping Xiong
    • Chuan He
    Research
    Nature Cell Biology
    Volume: 23, P: 684-691