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Showing 1–3 of 3 results
Advanced filters: Author: Qingqiu Huang Clear advanced filters

  • Mutations in cysteine string protein-α (CSPα) cause its aggregation and adult-onset neuronal ceroid lipofuscinosis. Abnormal binding of Fe–S clusters to CSPα mutants is now implicated in driving aggregation, which can be reversed in neurons by clinically approved iron chelators.

    • Nima N. Naseri
    • Burçe Ergel
    • Manu Sharma
    Research
    Nature Structural & Molecular Biology
    Volume: 27, P: 192-201

  • Plant pathogens produce effector proteins that enhance virulence in susceptible plants, but trigger an immune response in resistant plants. This hypersensitive response is elicited through the interaction between the bacterial effector and the appropriate host resistance protein. This study describes the first crystal structure of a pathogen effector (AvrPto) bound to its cognate host protein (Pto).

    • Weiman Xing
    • Yan Zou
    • Jijie Chai
    Research
    Nature
    Volume: 449, P: 243-247