Wang et al. find that the therapeutic agent cisplatin has opposite effect on acetylation of serine-arginine protein kinase 1 (SRPK1) in cisplatin-resistant versus – sensitive breast cancer cells. Inhibiting SRPK1 activity or enhancing its acetylation re-sensitises cells to cisplatin, suggesting a potential strategy to treat cancers resistant to platinum-based therapy.
- Cheng Wang
- Zhihong Zhou
- Qidong Hu
