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Immunotherapy and senolytics in head and neck squamous cell carcinoma: phase 2 trial results

Two phase 2 trials, along with translational analysis of prospective cohorts and experimental analysis, indicate that immunosenescence as a mechanism of resistance to immunotherapy can be overcome with the senolytics dasatinib and quercetin in patients with head and neck squamous cell carcinoma.

Niu Liu
Jiaying Wu
Song Fan
Research25 Aug 2025
Nature Medicine

Volume: 31, P: 3047-3061
A resource of large-scale molecular markers for monitoring Agropyron cristatum chromatin introgression in wheat background based on transcriptome sequences

Jinpeng Zhang
Weihua Liu
Lihui Li
ResearchOpen Access20 Sept 2017
Scientific Reports

Volume: 7, P: 1-8
Chiral gold nanoparticles enantioselectively rescue memory deficits in a mouse model of Alzheimer’s disease

Nanoparticles are being explored as a potential method to target Aβ aggregation in Alzheimer’s disease. Here, the authors develop gold nanoparticles that were capped with chiral L or D-glutathione which has been shown to improve BBB permeability and demonstrate their ability to improve cognitive function in a mouse model of AD.

Ke Hou
Jing Zhao
Zhiyong Tang
ResearchOpen Access22 Sept 2020
Nature Communications

Volume: 11, P: 1-11
Prognostic value of tertiary lymphoid structure and tumour infiltrating lymphocytes in oral squamous cell carcinoma

Qunxing Li
Xiangqi Liu
Zhi Wang
ResearchOpen Access15 Sept 2020
International Journal of Oral Science

Volume: 12, P: 1-8
LncRNA KCNQ1OT1 regulates proliferation and cisplatin resistance in tongue cancer via miR-211-5p mediated Ezrin/Fak/Src signaling

Shanyi Zhang
Hanyu Ma
Youyuan Wang
ResearchOpen Access03 Jul 2018
Cell Death & Disease

Volume: 9, P: 1-16
A comprehensive profile of TCF1⁺ progenitor and TCF1⁻ terminally exhausted PD-1⁺CD8⁺ T cells in head and neck squamous cell carcinoma: implications for prognosis and immunotherapy

Dikan Wang
Juan Fang
Zhi Wang
ResearchOpen Access14 Feb 2022
International Journal of Oral Science

Volume: 14, P: 1-9

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Immunotherapy and senolytics in head and neck squamous cell carcinoma: phase 2 trial results

A resource of large-scale molecular markers for monitoring Agropyron cristatum chromatin introgression in wheat background based on transcriptome sequences

Chiral gold nanoparticles enantioselectively rescue memory deficits in a mouse model of Alzheimer’s disease

Prognostic value of tertiary lymphoid structure and tumour infiltrating lymphocytes in oral squamous cell carcinoma

LncRNA KCNQ1OT1 regulates proliferation and cisplatin resistance in tongue cancer via miR-211-5p mediated Ezrin/Fak/Src signaling

A comprehensive profile of TCF1+ progenitor and TCF1− terminally exhausted PD-1+CD8+ T cells in head and neck squamous cell carcinoma: implications for prognosis and immunotherapy

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A comprehensive profile of TCF1⁺ progenitor and TCF1⁻ terminally exhausted PD-1⁺CD8⁺ T cells in head and neck squamous cell carcinoma: implications for prognosis and immunotherapy