Nature Search

A unified framework for systematic curation and evaluation of aging biomarkers

Ying, Paulson and collagues have developed an open-source framework, Biolearn, to harmonize and systematically evaluate 39 aging biomarkers across diverse populations, enabling standardized validation and facilitating development of robust aging biomarkers.

Kejun Ying
Seth Paulson
Vadim N. Gladyshev
Research04 Nov 2025
Nature Aging

Volume: 5, P: 2323-2339
Single amino acid substitutions in influenza haemagglutinin change receptor binding specificity

G. N. Rogers
J. C. Paulson
D. C. Wiley
Research01 Jul 1983
Nature

Volume: 304, P: 76-78
Erythrocyte receptors for Mycoplasma pneumoniae are sialylated oligosaccharides of Ii antigen type

Lesley M. Loomes
Kei-ichi Uemura
Ten Feizi
Research09 Feb 1984
Nature

Volume: 307, P: 560-563
SmartEM: machine learning-guided electron microscopy

SmartEM is a ‘smart’ pipeline for electron microscopy-based data acquisition for connectomics. In order to efficiently image large datasets, the approach involves imaging at short pixel dwell times and identifying problematic regions that are then imaged with longer dwell times and therefore higher quality.

Yaron Meirovitch
Ishaan Singh Chandok
Nir Shavit
Research29 Dec 2025
Nature Methods

Volume: 23, P: 193-204
Combined surgery and chemotherapy for the treatment of primary gastrointestinal intermediate- or high-grade non-Hodgkin's lymphomas

G Bellesi
R Alterini
P Rossi Ferrini
Research01 Aug 1989
British Journal of Cancer

Volume: 60, P: 244-248
The DFer gene of Drosophila melanogaster encodes two membrane-associated proteins that can both transform vertebrate cells

R Paulson
J Jackson
J M Bishop
Research13 Feb 1997
Oncogene

Volume: 14, P: 641-652
The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington's disease

Susan E. Andrew
Y. Paul Goldberg
Michael R. Hayden
Research01 Aug 1993
Nature Genetics

Volume: 4, P: 398-403
1 : 2 : 2 : 6 : 6-Pentamethylpiperidine: a New Hypotensive Drug

G. E. LEE
W. R. WRAGG
H. W. READING
Research21 Jun 1958
Nature

Volume: 181, P: 1717-1719
Lidar detection of leads in Arctic sea ice

R. C. Schnell
R. G. Barry
J. L. Moore
Research15 Jun 1989
Nature

Volume: 339, P: 530-532
A New Method of Ciliary Feeding in the Brachiopod Neothyris lenticularis

JOYCE R. RICHARDS
Research27 Aug 1949
Nature

Volume: 164, P: 367-368
Multicolor cathodoluminescence imaging of single lanthanide nanoparticles

Electron-induced light, cathodoluminescence, enables nanoscale optical analysis across disciplines. Here, the authors achieve multicolor cathodoluminescence imaging of sub-15-nm lanthanide nanoparticles and demonstrate its application for bioimaging.

Sohaib Abdul Rehman
Jeremy B. Conway
Maxim B. Prigozhin
ResearchOpen Access31 Oct 2025
Nature Communications

Volume: 16, P: 1-13
Transgenic expression of E2F3a causes DNA damage leading to ATM-dependent apoptosis

Q X Paulson
R V Pusapati
D G Johnson
Research12 May 2008
Oncogene

Volume: 27, P: 4954-4961
Apparent surface conductance sensitivity to vapour pressure deficit in the absence of plants

Surface conductance variations in non-vegetated salt flats are similar to those in vegetated ecosystems and in an idealized boundary layer model. This suggests that soil moisture, and not vapour pressure deficit, controls surface conductance variations.

Lucas R. Vargas Zeppetello
Kaighin A. McColl
Peter Huybers
Research16 Oct 2023
Nature Water

Volume: 1, P: 941-951
GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia

Genome-wide analyses identify common variants associated with 11 distinct neuropathology endophenotypes, providing insights into the mechanisms underlying the genetic risk of Alzheimer’s disease and related dementias.

Lincoln M. P. Shade
Yuriko Katsumata
David W. Fardo
ResearchOpen Access08 Oct 2024
Nature Genetics

Volume: 56, P: 2407-2421
Hormonal Interrelations in Beef Cows with Induced Multiple Ovulations

D. M. HENRICKS
D. R. LAMOND
Research28 Jan 1972
Nature

Volume: 235, P: 222-223
Effects of Thiols on Escherichia coli β-Galactosidases

F. J. REITHEL
R. M. NEWTON
M. EAGLESON
Research18 Jun 1966
Nature

Volume: 210, P: 1265
Transition from high- to low-NO_x control of night-time oxidation in the southeastern US

The influence of NO_x levels at night on atmospheric oxidation is unclear. Analyses of aircraft observations suggest that night-time oxidation is transitioning from a high- to low-NO_x regime in the southeast US due to declines in NO_x levels.

P. M. Edwards
K. C. Aikin
S. S. Brown
Research26 Jun 2017
Nature Geoscience

Volume: 10, P: 490-495
Generation of field-reversed configurations via neutral beam injection

The field-reversal configuration (FRC) represents a fusion device concept capable of high power density with a compact geometry. Here, the authors report on the generation and sustainment of a FRC by means of neutral beam injection in the C-2W machine at TAE technologies. This contributes towards establishing FRC as an alternative economic fusion device.

T. Roche
S. Dettrick
M. W. Binderbauer
ResearchOpen Access12 Apr 2025
Nature Communications

Volume: 16, P: 1-11
Plasma Acoustic Propagation in the Ionosphere

R. S. IYENGAR
Research20 Dec 1969
Nature

Volume: 224, P: 1191-1192
Biomaterials with droplet microfluidics

Droplet microfluidics enables the precise fabrication of microgels, which are microscale hydrogel particles that serve as modular building blocks for biomaterials. This Review outlines principles of microfluidic microgel production, strategies for tailoring structure and functionality, and applications spanning drug delivery, cell culture and tissue engineering, while highlighting current challenges and future directions.

Yangteng Ou
Zexiang Han
Tuomas P. J. Knowles
Reviews02 Jan 2026
Nature Reviews Bioengineering

P: 1-18
Radiolysis of Liquid Acetone : Effect of Dose-rate and Linear Energy Transfer

R. BARKER
Research07 Oct 1961
Nature

Volume: 192, P: 62-63
Expressed genes, Alu repeats and polymorphisms in cosmids sequenced from chromosome 4p16.3

W.R. McCombie
A. Martin-Gallardo
J.C. Venter
Research01 Aug 1992
Nature Genetics

Volume: 1, P: 348-353
Structure of simian virus 40 at 3.8-Å resolution

R. C. Liddington
Y. Yan
S. C. Harrison
Research28 Nov 1991
Nature

Volume: 354, P: 278-284
Automated DNA sequencing and analysis of 106 kilobases from human chromosome 19q13.3

A. Martin-Gallardo
W. R. McCombie
J. C. Venter
Research01 Apr 1992
Nature Genetics

Volume: 1, P: 34-39
Rational design of potent sialidase-based inhibitors of influenza virus replication

Mark von Itzstein
Wen-Yang Wu
Charles R. Penn
Research03 Jun 1993
Nature

Volume: 363, P: 418-423
Glycocalyx engineering reveals a Siglec-based mechanism for NK cell immunoevasion

Defined phospholipid-functionalized glycopolymers serve as a new tool to identify the mechanistic connection between hypersialylation and immunoprotection, where hypersialylation of tumor cells subverts the immunosurveillance mechanism of NK cells by recruiting the lectin Siglec-7 to inhibit human NK cell activation.

Jason E Hudak
Stephen M Canham
Carolyn R Bertozzi
Research24 Nov 2013
Nature Chemical Biology

Volume: 10, P: 69-75
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains

CD22 inhibits microglial phagocytosis in the ageing brain, and treatment with a CD22-blocking antibody restores microglial homeostasis and cognitive function in ageing mice.

John V. Pluvinage
Michael S. Haney
Tony Wyss-Coray
Research03 Apr 2019
Nature

Volume: 568, P: 187-192
Six principles to get natural climate solutions right in Africa

Nature-based climate solutions tend to overlook Africa’s diverse contexts and development priorities. We propose six guiding principles centred on the aspirations of African peoples, recognizing the cultural connection of communities to their environments and the role of biodiversity in sustaining livelihoods and identities.

Laura M. Pereira
Sally Archibald
U. Rashid Sumaila
Comments & Opinion02 Oct 2025
Nature Sustainability

Volume: 8, P: 1238-1241
Multiple organ-reactive monoclonal autoantibodies

Martin V. Haspel
Takashi Onodera
Abner Louis Notkins
Research01 Jul 1983
Nature

Volume: 304, P: 73-76
Conformational disease

Ron R. Kopito
David Ron
News & Views01 Nov 2000
Nature Cell Biology

Volume: 2, P: E207-E209
Deficient production of tyramine and octopamine in cases of depression

M. SANDLER
C. R. J. RUTHVEN
A. COPPEN
Research01 Mar 1979
Nature

Volume: 278, P: 357-358
Resorbing bone is chemotactic for monocytes

GREGORY R. MUNDY
JAMES VARANI
PETER A. WARD
Research01 Sept 1978
Nature

Volume: 275, P: 132-135
Goal-specific hippocampal inhibition gates learning

Parvalbumin-positive interneurons in the hippocampal CA3 substantially reduce firing on approach to and at goal locations while food-deprived mice learn to find food.

Nuri Jeong
Xiao Zheng
Annabelle C. Singer
ResearchOpen Access09 Apr 2025
Nature

Volume: 642, P: 1007-1015
LETTER TO THE EDITORS

Tong H Lee
Everett H Ellinwood Jr
George R King
Correspondence01 Apr 1997
Neuropsychopharmacology

Volume: 16, P: 311-312
Sequence identification of 2,375 human brain genes

Mark D. Adams
Mark Dubnick
J. Craig Venter
Research13 Feb 1992
Nature

Volume: 355, P: 632-634
Scaffold-hopping for molecular glues targeting the 14-3-3/ERα complex

Molecular glues have great potential for drug discovery if they can be systematically discovered. Konstantinidou, et al describe a scaffold-hopping approach using multicomponent reaction chemistry to design molecular glues that induce 14-3- 3σ/ERα formation in cells.

Markella Konstantinidou
Marios Zingiridis
Michelle R. Arkin
ResearchOpen Access14 Jul 2025
Nature Communications

Volume: 16, P: 1-13
Spin-acoustic control of silicon vacancies in 4H silicon carbide

Acoustically driven spin control of silicon monovacancies can be used to measure the resonant properties and dynamical strain distribution in lateral overtone bulk acoustic resonators.

Jonathan R. Dietz
Boyang Jiang
Evelyn L. Hu
ResearchOpen Access21 Sept 2023
Nature Electronics

Volume: 6, P: 739-745
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Large genome-wide meta-analysis of clinically diagnosed late-onset Alzheimer’s disease (LOAD) from 94,437 individuals identifies new LOAD risk loci and implicates Aβ formation, tau protein binding, immune response and lipid metabolism.

Brian W. Kunkle
Benjamin Grenier-Boley
Margaret A. Pericak-Vance
Research28 Feb 2019
Nature Genetics

Volume: 51, P: 414-430
Spatial orientation of molecules in strong electric fields and evidence for pendular states

Bretislav Friedrich
Dudley R. Herschbach
Research03 Oct 1991
Nature

Volume: 353, P: 412-414
Integrated molecular and multiparametric MRI mapping of high-grade glioma identifies regional biologic signatures

Glioma tumours are known to be heterogenous in mutation and gene expression patterns, but sampling limitations can lead to inaccurate detection of evolutionary events. Here, the authors carry out multi-omics analysis of multi-regional biopsies from 68 patients and show differential mutations in non-enhancing regions.

Leland S. Hu
Fulvio D’Angelo
Nhan L. Tran
ResearchOpen Access28 Sept 2023
Nature Communications

Volume: 14, P: 1-20
Nanoscale wetting controls reactive Pd ensembles in synthesis of dilute PdAu alloy catalysts

The catalytic performance of dilute Pd-in-Au alloys depends on the Pd ensemble size on the bimetallic nanoparticle surface. Here the authors reveal how Pd ensemble formation on Au nanoparticles depends on the deposition sequence and nanoparticle–support wetting interactions, consequently affecting reactivity.

Kang Rui Garrick Lim
Cameron J. Owen
Joanna Aizenberg
ResearchOpen Access08 Jul 2025
Nature Communications

Volume: 16, P: 1-12
Epistasis mediates the evolution of the receptor binding mode in recent human H3N2 hemagglutinin

The receptor binding mode of recent human H3N2 hemagglutinin has evolved due to mutations G186D and D190N, which epistatically interact and co-emerged in clades 3C.2a1b.1a and 3C.2a1b.2a2.

Ruipeng Lei
Weiwen Liang
Nicholas C. Wu
ResearchOpen Access18 Jun 2024
Nature Communications

Volume: 15, P: 1-12
Glycolipid affinity purification of migration inhibitory factor

David Y. Liu
John R. David
Heinz G. Remold
Research04 Mar 1982
Nature

Volume: 296, P: 78-80
A new mechanism for induced vitamin D deficiency in calcium deprivation

M. R. Clements
L. Johnson
D. R. Fraser
Research01 Jan 1987
Nature

Volume: 325, P: 62-65
Building personalized machine learning models using real-time monitoring data to predict idiographic suicidal thoughts

Using ecological monetary assessment, this study presents findings from idiographic models built to predict suicidal ideation in individuals after psychiatric hospitalization.

Shirley B. Wang
Ruben D. I. Van Genugten
Matthew K. Nock
Research24 Oct 2024
Nature Mental Health

Volume: 2, P: 1382-1391
UbiB proteins regulate cellular CoQ distribution in Saccharomyces cerevisiae

Coenzyme Q (CoQ) is a lipid made in the inner mitochondrial membrane with antioxidant roles throughout the cell, but regulation of its cellular distribution is unclear. Here the authors identify two proteins that have reciprocal CoQ trafficking functions to help coordinate CoQ localization in yeast.

Zachary A. Kemmerer
Kyle P. Robinson
David J. Pagliarini
ResearchOpen Access06 Aug 2021
Nature Communications

Volume: 12, P: 1-11
Decoding the mechanophysiology for inhaled onset of smallpox with model-based implications for mpox spread

Mohammad Yeasin
Mohammad Mehedi Hasan Akash
Saikat Basu
ResearchOpen Access14 Dec 2025
Scientific Reports

Volume: 16, P: 1-20
Large-scale quantum-emitter arrays in atomically thin semiconductors

Quantum emitters have been recently isolated in 2D materials, yet their spatial controllability remains an open challenge. Here, the authors devise a method to create arrays of quantum emitters in WSe₂ and WS₂, by taking advantage of the strain distribution induced by a nanopatterned silica substrate.

Carmen Palacios-Berraquero
Dhiren M. Kara
Mete Atatüre
ResearchOpen Access22 May 2017
Nature Communications

Volume: 8, P: 1-6
Charge measurements on particle fallout from a volcanic plume

J. S. Gilbert
S. J. Lane
T. Koyaguchi
Research14 Feb 1991
Nature

Volume: 349, P: 598-600
Fibre-infused gel scaffolds guide cardiomyocyte alignment in 3D-printed ventricles

A gelatin–alginate hydrogel ink incorporating short gelatin fibres guides the self-organization of human cardiomyocytes into contractile tissues that can be 3D-printed into structures mimicking human organs.

Suji Choi
Keel Yong Lee
Kevin Kit Parker
Research27 Jul 2023
Nature Materials

Volume: 22, P: 1039-1046

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