Desynchronization of circadian rhythms is a common occurrence in individuals presenting with sleep disorders. In this Review, Pandi-Perumal et al. highlight the roles of light and endogenous melatonin in the synchronization of sleep–wake rhythms and rest–activity cycles with the light–dark cycle, and they discuss how light therapy and exogenous melatonin might be used to treat circadian rhythm sleep disorders.
- Seithikurippu R Pandi-Perumal
- Ilya Trakht
- Daniel P Cardinali
