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RNA methyltransferase SPOUT1/CENP-32 links mitotic spindle organization with the neurodevelopmental disorder SpADMiSS

The RNA methyltransferase activity of SPOUT1/CENP-32 is crucial for accurate mitotic spindle organization. Here, the authors describe a neurodevelopmental disorder caused by bi-allelic pathogenic SPOUT1 variants with reduced activity and compromised function in spindle organization.

Avinash V. Dharmadhikari
Maria Alba Abad
Jun Liao
ResearchOpen Access17 Feb 2025
Nature Communications

Volume: 16, P: 1-24
EB1 regulates attachment of Ska1 with microtubules by forming extended structures on the microtubule lattice

Ska1 is a kinetochore-localised protein that couples kinetochore movement to microtubule (MT) depolymerisation. Here Thomas et al. show that the MT +TIP binding protein EB1 recruits Ska1 to the MT-kinetochore interface and stabilises the interaction between Ska1 and MTs.

Geethu E. Thomas
K. Bandopadhyay
Tapas K. Manna
ResearchOpen Access26 May 2016
Nature Communications

Volume: 7, P: 1-13
An Oryza-specific histone H4 variant predisposes H4 lysine 5 acetylation to modulate salt stress responses

An Oryza-specific histone H4 variant (H4.V) forms condensed, less stable nucleosomes. H4.V enhances the salt-stress-dependent deposition of H4 lysine 5 acetylation marks at several protein-coding loci, thereby regulating the salt stress transcriptome.

Vivek Hari-Sundar Gandhivel
Paula Sotelo-Parrilla
P. V. Shivaprasad
Research08 Apr 2025
Nature Plants

Volume: 11, P: 790-807
Cellular heterogeneity of pluripotent stem cell-derived cardiomyocyte grafts is mechanistically linked to treatable arrhythmias

Selvakumar, Clayton et al. use a porcine model of myocardial infarction and PSC-CM transplantation and identify atrial and pacemaker-like cardiomyocytes as the cause of engraftment arrhythmias and surface marker signatures to distinguish between arrhythmogenic and non-arrhythmogenic cardiomyocytes.

Dinesh Selvakumar
Zoe E. Clayton
James J. H. Chong
ResearchOpen Access06 Feb 2024
Nature Cardiovascular Research

Volume: 3, P: 145-165
Exploring target selectivity in designing and identifying PI3Kα inhibitors for triple negative breast cancer with fragment-based and bioisosteric replacement approach

Debojyoti Halder
Shreya Mukherjee
R. S. Jeyaprakash
ResearchOpen Access13 Jan 2025
Scientific Reports

Volume: 15, P: 1-22
Genome sequencing and comparative genomic analysis of bovine mastitis-associated non-aureus staphylococci and mammaliicocci (NASM) strains from India

Vishnukumar Ramesh
Ramamoorthy Sivakumar
Nagendra R. Hegde
ResearchOpen Access22 Nov 2024
Scientific Reports

Volume: 14, P: 1-13
Wolbachia plays no role in the one-way reproductive incompatibility between the hybridizing field crickets Gryllus firmus and G. pennsylvanicus

L S Maroja
M E Clark
R G Harrison
Research06 Aug 2008
Heredity

Volume: 101, P: 435-444
Variable fitness effects of Wolbachia infection in Drosophila melanogaster

A J Fry
M R Palmer
D M Rand
Research11 Aug 2004
Heredity

Volume: 93, P: 379-389
Disabling the mitotic spindle and tumor growth by targeting a cavity-induced allosteric site of survivin

A Berezov
Z Cai
Q Wang
Research05 Sept 2011
Oncogene

Volume: 31, P: 1938-1948
Bidirectional incompatibility among divergent Wolbachia and incompatibility level differences among closely related Wolbachia in Nasonia

S R Bordenstein
J H Werren
Research23 May 2007
Heredity

Volume: 99, P: 278-287
IAP-targeted therapies for cancer

E C LaCasse
D J Mahoney
R G Korneluk
Reviews20 Oct 2008
Oncogene

Volume: 27, P: 6252-6275

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RNA methyltransferase SPOUT1/CENP-32 links mitotic spindle organization with the neurodevelopmental disorder SpADMiSS

EB1 regulates attachment of Ska1 with microtubules by forming extended structures on the microtubule lattice

An Oryza-specific histone H4 variant predisposes H4 lysine 5 acetylation to modulate salt stress responses

Cellular heterogeneity of pluripotent stem cell-derived cardiomyocyte grafts is mechanistically linked to treatable arrhythmias

Exploring target selectivity in designing and identifying PI3Kα inhibitors for triple negative breast cancer with fragment-based and bioisosteric replacement approach

Genome sequencing and comparative genomic analysis of bovine mastitis-associated non-aureus staphylococci and mammaliicocci (NASM) strains from India

Wolbachia plays no role in the one-way reproductive incompatibility between the hybridizing field crickets Gryllus firmus and G. pennsylvanicus

Variable fitness effects of Wolbachia infection in Drosophila melanogaster

Disabling the mitotic spindle and tumor growth by targeting a cavity-induced allosteric site of survivin

Bidirectional incompatibility among divergent Wolbachia and incompatibility level differences among closely related Wolbachia in Nasonia

IAP-targeted therapies for cancer

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