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Showing 1–16 of 16 results
Advanced filters: Author: Rachel A. Botting Clear advanced filters

  • Transcriptomic and proteomic profiling of blood samples from individuals with COVID-19 reveals immune cell and hematopoietic progenitor cell alterations that are differentially associated with disease severity.

    • Emily Stephenson
    • Gary Reynolds
    • Muzlifah Haniffa
    ResearchOpen Access
    Nature Medicine
    Volume: 27, P: 904-916

  • A comprehensive multi-omics reference atlas of prenatal human skin shows that innate immune cells crosstalk with non-immune cells to perform pivotal roles in skin morphogenesis, including the formation of hair follicles.

    • Nusayhah Hudaa Gopee
    • Elena Winheim
    • Muzlifah Haniffa
    ResearchOpen Access
    Nature
    Volume: 635, P: 679-689

  • Single-cell transcriptomic profiling of fetal liver, skin, kidney and yolk sac reveals the differentiation trajectories of human haematopoietic stem cells and multipotent progenitors, which are validated to produce an integrated map of fetal liver haematopoiesis.

    • Dorin-Mirel Popescu
    • Rachel A. Botting
    • Muzlifah Haniffa
    Research
    Nature
    Volume: 574, P: 365-371

  • Composition and function of immune populations at barrier surfaces is crucial for response to infection. Here, the authors identify a population of dendritic cells in human epidermis, abundant in anogenital epithelia and distinct from Langerhans cells by surface phenotype and by high capacity for HIV infection and transmission.

    • Kirstie M. Bertram
    • Rachel A. Botting
    • Andrew N. Harman
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15

  • G9a is involved in gene silencing during early embryonic development, catalyzing the methylation of H3K9, which results in heterochromatinization, and also promoting methylation of DNA de novo. These two G9a activities are now dissected, and de novo DNA methylation is shown to occur via recruitment of Dnmt3a/3b and to be necessary and sufficient to prevent reprogramming.

    • Silvina Epsztejn-Litman
    • Nirit Feldman
    • Yehudit Bergman
    Research
    Nature Structural & Molecular Biology
    Volume: 15, P: 1176-1183

  • The innate immune response in epithelial cells after SARS-CoV-2 infection is not fully understood. Here the authors use human air-liquid interface culture and show single cell transcription changes and delayed type I Interferon responses after SARS-CoV-2 infection compared with other respiratory viruses.

    • Catherine F. Hatton
    • Rachel A. Botting
    • Christopher J. A. Duncan
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17

  • Epithelial tissue mononuclear phagocytes (MNP) can transmit HIV to CD4 T cells, but less is known about sub-epithelial cells. Here, the authors describe MNPs in human anogenital and colorectal tissues and find that CD14+CD1c+ monocyte-derived dendritic cells and langerin-expressing conventional dendritic cells 2 preferentially take up and transmit HIV.

    • Jake W. Rhodes
    • Rachel A. Botting
    • Andrew N. Harman
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15

  • A single-cell atlas of human fetal bone marrow in healthy fetuses and fetuses with Down syndrome provides insight into developmental haematopoiesis in humans and the transcription and functional differences that occur in Down syndrome.

    • Laura Jardine
    • Simone Webb
    • Muzlifah Haniffa
    Research
    Nature
    Volume: 598, P: 327-331

  • Cells from embryonic, fetal, paediatric and adult human intestinal tissue are analysed at different locations along the intestinal tract to construct a single-cell atlas of the developing and adult human intestinal tract, encompassing all cell lineages.

    • Rasa Elmentaite
    • Natsuhiko Kumasaka
    • Sarah A. Teichmann
    ResearchOpen Access
    Nature
    Volume: 597, P: 250-255

  • Through analysis of the electronic medical records of 284,592 vaccinated patients, using a sequence–symmetry analysis, Kwan et al. show that the risk of postural orthostatic tachycardia syndrome (POTS) is increased after COVID-19 vaccination compared to a 90-day control period before exposure—although 5.35 times lower than the risk of POTS occurrence after SARS-CoV-2 infection.

    • Alan C. Kwan
    • Joseph E. Ebinger
    • Susan Cheng
    Research
    Nature Cardiovascular Research
    Volume: 1, P: 1187-1194

  • This study provides a comprehensive spatiotemporal map of human and mouse gonadal differentiation, using a combination of single-cell and spatial transcriptomics, chromatin accessibility assays and fluorescent microscopy, which can guide in vitro gonadogenesis.

    • Luz Garcia-Alonso
    • Valentina Lorenzi
    • Roser Vento-Tormo
    ResearchOpen Access
    Nature
    Volume: 607, P: 540-547

  • Transcriptomes of about 70,000 single cells from first-trimester deciduas and placentas reveal subsets of perivascular, stromal and natural killer cells in the decidua, with distinct immunomodulatory profiles that regulate the environment necessary for successful placentation.

    • Roser Vento-Tormo
    • Mirjana Efremova
    • Sarah A. Teichmann
    Research
    Nature
    Volume: 563, P: 347-353