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Showing 1–7 of 7 results
Advanced filters: Author: Rafiqul Hussain Clear advanced filters

  • Here the authors show that PD-1 controls coinhibitory receptor expression by Treg cells. The absence of PD-1 expression could induce CD30 expression, thereby enhancing Treg function and tumor escape, suggesting that CD30 might be a therapeutic target in cases of anti-PD-1 resistance.

    • Jing Xuan Lim
    • Tegan McTaggart
    • Shoba Amarnath
    ResearchOpen Access
    Nature Immunology
    Volume: 26, P: 1074-1086

  • Immune-mediated inflammatory diseases such as rheumatoid arthritis (RA) are characterised by relapsing-remitting flares, which are difficult to study due to their unpredictable nature. Here the authors use an experimental model of immunomodulatory drug cessation in RA patients combined with multi-omic analysis of circulating leukocytes to characterise the immune response for those with arthritis flare versus drug-free remission.

    • Kenneth F. Baker
    • David McDonald
    • John D. Isaacs
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16

  • Formation of the retina during development involves the coordinated action of retinal progenitor cells and their differentiated cell types, which is key for producing a functioning eye. Here the authors provide a detailed atlas of human retinal development, combining scRNA-seq and spatial transcriptomics, and identify key genetic factors that mediate retinal progenitor cell proliferation and differentiation.

    • Birthe Dorgau
    • Joseph Collin
    • Majlinda Lako
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • A single-cell atlas of human fetal bone marrow in healthy fetuses and fetuses with Down syndrome provides insight into developmental haematopoiesis in humans and the transcription and functional differences that occur in Down syndrome.

    • Laura Jardine
    • Simone Webb
    • Muzlifah Haniffa
    Research
    Nature
    Volume: 598, P: 327-331

  • The innate immune response in epithelial cells after SARS-CoV-2 infection is not fully understood. Here the authors use human air-liquid interface culture and show single cell transcription changes and delayed type I Interferon responses after SARS-CoV-2 infection compared with other respiratory viruses.

    • Catherine F. Hatton
    • Rachel A. Botting
    • Christopher J. A. Duncan
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17