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Showing 1–2 of 2 results
Advanced filters: Author: Raheem Fazal Clear advanced filters

  • This study shows that C9orf72 mutations impair immune activation in ALS, affecting how brain cells communicate, and highlights key differences in the cellular and molecular pathways underlying sporadic and genetic forms of the disease.

    • Pegah Masrori
    • Baukje Bijnens
    • Philip Van Damme
    ResearchOpen Access
    Nature Neuroscience
    Volume: 28, P: 2217-2230

  • While energy metabolism has been repeatedly linked to ALS, motor neuron metabolism remains poorly studied. Here, authors show that human iPSCs rewire specific metabolic routes when they differentiate into functional motor neurons and that ALS-causing mutations in FUS do not affect energy metabolism.

    • Tijs Vandoorne
    • Koen Veys
    • Ludo Van Den Bosch
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12