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Showing 1–3 of 3 results
Advanced filters: Author: Ralf B. Nehring Clear advanced filters

  • The emergence of antibiotic resistance, even against last-line antibiotics such as colistin, is a serious public health threat. To guide treatment and drug development strategies, Marciano et al. apply evolutionary action (EA) analysis to identify driver mutations in a noisy mutational background in experimental evolution experiments and inform about de novo colistin resistance drivers.

    • David C. Marciano
    • Chen Wang
    • Olivier Lichtarge
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • Transcription termination or pausing during DNA replication in bacteria and humans results in DNA damage with exposed 3′ single-stranded DNA ends and mutations.

    • Jingjing Liu
    • Jullian O. Perren
    • Susan M. Rosenberg
    Research
    Nature
    Volume: 640, P: 240-248

  • Proferroptotic activity of 7-dehydrocholesterol reductase is shown along with an unexpected prosurvival function of its substrate, 7-dehydrocholesterol, indicating a cell-intrinsic mechanism that could be used by cancer cells to protect phospholipids from oxidative damage and escape ferroptosis.

    • Florencio Porto Freitas
    • Hamed Alborzinia
    • José Pedro Friedmann Angeli
    Research
    Nature
    Volume: 626, P: 401-410