Nature Search

Chamber-specific chromatin architecture guides functional interpretation of disease-associated Cis-regulatory elements in human cardiomyocytes

Here the authors functionally test and resolve the spatial genome organization of cis-regulatory elements and genetic variants in atrial, ventricular, and failing human cardiomyocytes and linked them to heart disease traits, including QT syndrome.

S. Haydar
R. Bednarz
R. Gilsbach
ResearchOpen Access12 Jan 2026
Nature Communications

Volume: 17, P: 1-21
Long non-coding RNAs direct the SWI/SNF complex to cell type-specific enhancers

The mechanisms directing chromatin remodeling complexes to genomic regions have remained elusive. Here, the authors show that lncRNAs direct SWI/SNF to cell type-specific enhancers, investigating an RNA-mediated layer of targeting specificity.

James A. Oo
Timothy Warwick
Matthias S. Leisegang
ResearchOpen Access02 Jan 2025
Nature Communications

Volume: 16, P: 1-13
Cardiac epigenome in heart development and disease

In this Review, Laurette and Gilsbach summarize the current knowledge on the cardiac epigenome, including the dynamic changes in DNA methylation, histone modifications and chromatin accessibility in cardiomyocytes during development and disease. They also describe the interplay between cell type-specific mechanisms and discuss the translational potential of targeting epigenetic mechanisms for the prevention and treatment of cardiac diseases.

Patrick Laurette
Ralf Gilsbach
Reviews02 Jan 2026
Nature Reviews Cardiology

P: 1-17
Dynamic DNA methylation orchestrates cardiomyocyte development, maturation and disease

DNA methylation is essential for proper gene expression, development and genome stability. Here the authors present whole-genome DNA methylation analyses of purified mouse cardiomyocytes from newborn, adult and failing hearts and find highly dynamic patterns between the three phenotypes of cardiomyocytes.

Ralf Gilsbach
Sebastian Preissl
Lutz Hein
ResearchOpen Access22 Oct 2014
Nature Communications

Volume: 5, P: 1-13
DNA methylation signatures follow preformed chromatin compartments in cardiac myocytes

Chromatin is organized in higher order A and B compartments, reflecting active and inactive chromatin. Here, the authors provide evidence that in cardiac myocytes DNA methylation is established in preformed chromatin compartments and may be dispensable for higher order chromatin organization.

Stephan Nothjunge
Thomas G. Nührenberg
Ralf Gilsbach
ResearchOpen Access21 Nov 2017
Nature Communications

Volume: 8, P: 1-9
HIF1α-AS1 is a DNA:DNA:RNA triplex-forming lncRNA interacting with the HUSH complex

Using a composite bioinformatics approach, the DNA:DNA:RNA triplex-forming lncRNAs HIF1α-AS1 was identified in human endothelial cells which recruits an epigenetic silencing complex to limit expression of triplex target genes.

Matthias S. Leisegang
Jasleen Kaur Bains
Ralf P. Brandes
ResearchOpen Access02 Nov 2022
Nature Communications

Volume: 13, P: 1-20
Distinct epigenetic programs regulate cardiac myocyte development and disease in the human heart in vivo

How the cardiac myocyte epigenome is rearranged during development, postnatal maturation and disease is not well understood. Here, the authors investigate the human cardiac myocyte epigenome during development and chronic heart failure and identify distinct epigenetic programs regulating these processes.

Ralf Gilsbach
Martin Schwaderer
Lutz Hein
ResearchOpen Access26 Jan 2018
Nature Communications

Volume: 9, P: 1-14
ZNF354C is a transcriptional repressor that inhibits endothelial angiogenic sprouting

James A. Oo
Barnabas Irmer
Matthias S. Leisegang
ResearchOpen Access05 Nov 2020
Scientific Reports

Volume: 10, P: 1-14
A hierarchical regulatory network analysis of the vitamin D induced transcriptome reveals novel regulators and complete VDR dependency in monocytes

Timothy Warwick
Marcel H. Schulz
Sabine Seuter
ResearchOpen Access22 Mar 2021
Scientific Reports

Volume: 11, P: 1-16
Author Correction: The in vivo specificity of synaptic Gβ and Gγ subunits to the α_2a adrenergic receptor at CNS synapses

Yun Young Yim
Katherine M. Betke
Heidi E. Hamm
Amendments and CorrectionsOpen Access14 Feb 2020
Scientific Reports

Volume: 10, P: 1
β₁-Adrenoceptor mRNA level reveals distinctions between infantile hemangioma and vascular malformations

Jochen Rössler
Miriam Haubold
Lutz Hein
Research31 Jan 2013
Pediatric Research

Volume: 73, P: 409-413
The in vivo specificity of synaptic Gβ and Gγ subunits to the α_2a adrenergic receptor at CNS synapses

Yun Young Yim
Katherine M. Betke
Heidi E. Hamm
ResearchOpen Access08 Feb 2019
Scientific Reports

Volume: 9, P: 1-12
α_2A-adrenergic heteroreceptors are required for stress-induced reinstatement of cocaine conditioned place preference

Rafael E. Perez
Aakash Basu
Danny G. Winder
Research19 Feb 2020
Neuropsychopharmacology

Volume: 45, P: 1473-1481

Search

Chamber-specific chromatin architecture guides functional interpretation of disease-associated Cis-regulatory elements in human cardiomyocytes

Long non-coding RNAs direct the SWI/SNF complex to cell type-specific enhancers

Cardiac epigenome in heart development and disease

Dynamic DNA methylation orchestrates cardiomyocyte development, maturation and disease

DNA methylation signatures follow preformed chromatin compartments in cardiac myocytes

HIF1α-AS1 is a DNA:DNA:RNA triplex-forming lncRNA interacting with the HUSH complex

Distinct epigenetic programs regulate cardiac myocyte development and disease in the human heart in vivo

ZNF354C is a transcriptional repressor that inhibits endothelial angiogenic sprouting

A hierarchical regulatory network analysis of the vitamin D induced transcriptome reveals novel regulators and complete VDR dependency in monocytes

Author Correction: The in vivo specificity of synaptic Gβ and Gγ subunits to the α_2a adrenergic receptor at CNS synapses

β₁-Adrenoceptor mRNA level reveals distinctions between infantile hemangioma and vascular malformations

The in vivo specificity of synaptic Gβ and Gγ subunits to the α_2a adrenergic receptor at CNS synapses

α_2A-adrenergic heteroreceptors are required for stress-induced reinstatement of cocaine conditioned place preference

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