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Showing 1–9 of 9 results
Advanced filters: Author: Ramon I. Klein Geltink Clear advanced filters

  • Lactate build up in the tumour microenvironments is thought to dampen anti-tumour immunity, but in vitro pre-conditioning T cells with lactate enhances anti-tumour activity in vivo in pre-clinical mouse models.

    • Ju Hee Oh
    • Anne-Sophie Archambault
    • Ramon I. Klein Geltink
    News & Views
    Nature Metabolism
    Volume: 5, P: 201-202

  • As macrophages switch to a proinflammatory gylcolytic state they start to generate triglyceride-rich lipid droplets, but what function these droplets have in this context is not clear. Here the authors show that this triglyceride synthesis is requisite for prostaglandin E2 production and subsequent inflammatory activation.

    • Angela Castoldi
    • Lauar B. Monteiro
    • Edward J. Pearce
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11

  • Cancers with concomitant SMARCA4/2 deficiencies are often resistant to chemotherapies and confer a poor prognosis. Here, the authors identify a metabolic dependency of these tumours on glutamine as an energy source and, using multiple approaches, demonstrate the efficacy of therapeutically targeting this vulnerability.

    • Xianbing Zhu
    • Zheng Fu
    • Sidong Huang
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16

  • The loss of T cell immune function as a result of human immunodeficiency virus (HIV) infection leads to opportunistic infections and certain HIV-associated cancers. Two recent studies shed light on the complex immunometabolic changes during HIV infection and open the door to metabolic treatment options that could ultimately cure HIV.

    • Ramon I. Klein Geltink
    News & Views
    Nature Metabolism
    Volume: 1, P: 653-655

  • HLX transcription factor regulates haematopoietic stem and progenitor cell (HSPC) differentiation and is overexpressed in acute myeloid leukemia. Here the authors show that HLX overexpression leads to myeloid differentiation block in zebrafish and human HSPCs by direct regulation of metabolic pathways.

    • Indre Piragyte
    • Thomas Clapes
    • Eirini Trompouki
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-17