High-grade serous ovarian cancer (HGSOC) is characterised by a complex tumour microenvironment contributing to poor clinical outcomes and resistance to therapy. Here, the authors develop a 3D pentaculture in vitro model of HGSOC incorporating five human cell types, revealing how malignant cells drive macrophage polarisation and influence the tumour microenvironment.
- Beatrice Malacrida
- Samar Elorbany
- Frances R. Balkwill
