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Showing 1–9 of 9 results
Advanced filters: Author: Raphaël Guérois Clear advanced filters

  • The WAVE regulatory complex activates Arp2/3 at the cell cortex and in membrane protrusions to generate persistent cell migration. Here authors show that PPP2R1A, a scaffold subunit of protein phosphatase 2, associates with an alternative form of the WAVE complex where WAVE, the subunit that activates Arp2/3, is replaced by NHSL1.

    • Yanan Wang
    • Giovanni Chiappetta
    • Alexis M. Gautreau
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-18

  • This study identified two plant synaptonemal complex central element proteins—SCEP1 and SCEP2. Mutant versions of these proteins do not synapse, have more crossovers but lose crossover interference and show reduced heterochiasmy.

    • Nathalie Vrielynck
    • Marion Peuch
    • Christine Mézard
    Research
    Nature Plants
    Volume: 9, P: 2016-2030

  • MCM8-9 and HROB function together in DNA damage response. Here, the authors describe the mechanism of DNA unwinding by MCM8-9 and its activation by HROB. HROB makes direct contacts with both MCM8 and MCM9 and promotes DNA unwinding downstream of MCM8-9 loading and hexameric ring formation on DNA.

    • Ananya Acharya
    • Hélène Bret
    • Petr Cejka
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • The ComFC protein is essential for natural transformation, a process that plays a major role in the spread of antibiotic resistance genes. Here the authors show that ComFC is a membrane-associated protein that participates in the transport of DNA through the cell membrane and the handling of the single-stranded DNA once delivered into the cytoplasm.

    • Prashant P. Damke
    • Louisa Celma
    • J. Pablo Radicella
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • The Mre11-Rad50 (MR) complex has key functions in the detection, signaling and repair of DNA breaks. Here the authors use transmission electron microscopy to show MR oligomerization is governed by a small beta-sheet protruding from the head domain of Rad50 at the base of the MR structure, and reveal MR head domain oligomerization is required for efficient DNA end resection.

    • Vera M. Kissling
    • Giordano Reginato
    • Matthias Peter
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • An enzymatic ensemble including Dna2 functions in DNA end resection; the function of the single-stranded DNA binding protein RPA in this complex has been underappreciated. Here the authors employ molecular modeling, biochemistry, and single molecule biophysics to reveal RPA directly promotes Dna2 recruitment, nuclease and helicase activities.

    • Ananya Acharya
    • Kristina Kasaciunaite
    • Petr Cejka
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15